Comparative study between different biomarkers for early prediction of gestational diabetes mellitus

Abstract

Hs-CRP and SHBG are important early predictors of GDM. Adding SHBG to hs-CRP improves specificity and serves good overall accuracy. Uric acid, creatinine and albumin have no role in GDM prediction.

First-trimester multimarker prediction of gestational diabetes mellitus using targeted mass spectrometry

“…Our data confirm that the adipocyte-derived hormone, adiponectin, is a specific independent predictor of GDM in both obese and non-obese women and directly compares its performance with those of a number of other previously suggested markers such as CRP, SHBG and the adipokines neutrophil gelatinase-associated lipocalin (NGAL), resistin and RBP-4 [14,[17][18][19][20][21][22][23][27][28][29][30][31][32].…”

“…Adiponectin is by far the best-studied protein biomarker for GDM but lacks the sensitivity and specificity required for clinical use [11][12][13][14][15][16]. Other proteins such as sex hormone binding protein (SHBG), retinol-binding protein 4 (RBP-4), resistin and C-reactive protein (CRP) have also been investigated as potential biomarkers of GDM, but conclusions have been variable [14,[17][18][19][20][21][22][23].…”

Gestational diabetes: An overview with attention for developing countries

“…Interestingly, glycated albumin is not infl uenced by iron defi ciency and therefore, it might be a better indicator of glycemic control in patients with GDM and pregnant women with diabetes mellitus (Hashimoto and Koga 2015). Moreover, highsensitive C-reactive protein (hs-CRP) and maternal serum sex hormone binding globulin (SHBG) are less used but can be important early predictors of GDM as well uric acid, creatinine, and albumin (Maged et al 2014). Measurement of serum PlGF at 11-14 weeks improves the performance of early screening for GDM (Eleft heriades et al 2014).…”

Porphyromonas gingivalis infection in gestational diabetes mellitus and survival in tobacco smokers.

“…Increased systemic inflammation has been suggested to be related to pregnancy complications, such as preeclampsia [54,270], with elevated levels of the acute phase protein, C-reactive protein (CRP), reported to be an effective early biomarker for GDM [271]. All women were recruited during the third semester, the stage of pregnancy when CRP levels have been reported to be highest in those with GDM [237].…”

“…Furthermore, poor glycemic control has been reported to result in increased subgingival infection with these same two pathogens [230]. Increased low-grade systemic inflammation has been suggested to be related to pregnancy complications, such as preeclampsia [54,270], with elevated levels of the acute phase protein, C-reactive protein (CRP), suggested to be an effective early biomarker for GDM [271].…”