Comparative study between lutein and its liposomal form on cisplatin-induced retinal injury in rabbits

Ibrahim, Amal E.; Shafaa, Medhat W.; Khedr, M.H.; Rashed, Rawda F

doi:10.1080/15569527.2019.1608227

Cited by 10 publications

(10 citation statements)

References 36 publications

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“…These data indicate that the ocular disorders found in patients treated with CIS may be due to an imbalance of antioxidant defenses and the production of ROS and nitrogen species, which induces cell damage and an inflammatory process. This premise can be supported by considering that antioxidant agents such as astaxanthin, rutin, coenzyme Q10, and lutein are able to reverse retinal dysfunctions related to CIS toxicity [ 114 , 115 , 116 , 117 , 118 ]. Interestingly, CIS treatment may be activating parallel signaling pathways that favor DNA damage response and cell survival [ 119 ].…”

Section: Drugs and Medicinementioning

confidence: 99%

Retinal Toxicity Induced by Chemical Agents

Araújo

Brito

Pereira-Figueiredo

et al. 2022

IJMS

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Vision is an important sense for humans, and visual impairment/blindness has a huge impact in daily life. The retina is a nervous tissue that is essential for visual processing since it possesses light sensors (photoreceptors) and performs a pre-processing of visual information. Thus, retinal cell dysfunction or degeneration affects visual ability and several general aspects of the day-to-day of a person’s lives. The retina has a blood–retinal barrier, which protects the tissue from a wide range of molecules or microorganisms. However, several agents, coming from systemic pathways, reach the retina and influence its function and survival. Pesticides are still used worldwide for agriculture, contaminating food with substances that could reach the retina. Natural products have also been used for therapeutic purposes and are another group of substances that can get to the retina. Finally, a wide number of medicines administered for different diseases can also affect the retina. The present review aimed to gather recent information about the hazard of these products to the retina, which could be used to encourage the search for more healthy, suitable, or less risky agents.

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Section: Drugs and Medicinementioning

confidence: 99%

Retinal Toxicity Induced by Chemical Agents

Araújo

Brito

Pereira-Figueiredo

et al. 2022

IJMS

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show abstract

“…The neuroprotective effect of lutein in liposome form against cisplatin-induced retinal injury in rabbits was also studied. They concluded that liposomal lutein could prevent the detrimental effects of cisplatin on the retina [100]. Rabbit ocular tissues were used to evaluate the toxicity profile of lutein and zeaxanthin, along with brilliant blue dye.…”

Section: Other Animal Modelsmentioning

confidence: 99%

The macular carotenoids: A biochemical overview

Arunkumar

Gorusupudi

Bernstein

2020

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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“…These formulations can be considered as an appropriate carrier to target and deliver drugs to the retina tissue ( ER et al, 2021 ). In another study, Ibrahim et al (2019) evaluated the protective and anti-oxidative effects of liposomal forms of lutein in cisplatin-induced retinal injury in rabbit eyes. Liposome prepared by the thin-film hydration technique were injected into the peritoneal cavity.…”

Section: Application Of Nanotechnology For Ocular Drug Deliverymentioning

confidence: 99%

“…The rabbit retina was analyzed by the Comet assay, electroretinogram (ERG), and histopathological examination. The result demonstrated that liposomal lutein formulation could be beneficial to avoid the deleterious effects of cisplatin on the rabbits’ retina and prevent DNA and histopathological damage ( Ibrahim et al, 2019 ).…”

Section: Application Of Nanotechnology For Ocular Drug Deliverymentioning

confidence: 99%