Comparative study between meshes of polyester with collagen and polytetrafluoroethylene in the repair of defects produced in abdominal wall of rats

Abstract

<jats:p>PURPOSE: To study the intraperitoneal use of polyester with collagen and polytetrafluoroethylene meshes in the correction of total ventral wall defects in rats. METHODS: Thirty two rats were evaluated and divided randomly into four groups and underwent laparotomy and preparation of total defects of the abdominal wall. Next, the correction of the defect with the intraperitoneal placement of the chosen mesh was performed. The rats were submitted to euthanasia at 30 and 90 days after surgery. Were analyzed the macroscopic adhesions and microscopic aspects, and applied stress rupture test RESULTS: All animals showed intraperitoneal adhesions in varying degrees, with no statistical significance difference. There was no difference also between groups in the evaluation of stress rupture tests. On the microscopic aspect, the A30 group had less inflammatory reaction and less formation of granulomas and foreign body reaction that the B30 group, with significant difference. CONCLUSIONS: There was no difference in intraperitoneal adhesion and tensile rupture strength among groups. Group B30 presented granulomatous inflammatory reaction at the site of mesh attachment to the wall significantly higher than the A30.</jats:p>

Effect of copaiba oil on correction of abdominal wall defect treated with the use of polypropylene/polyglecaprone mesh

“…These exudates entail temporary adhesions and can delay the healing process. Almost all meshes may produce adhesions when they are in contact with the intestinal surface and this process is determined by the size of the pores and by the structure of the surface area of the mesh 20 .…”

Critical Analysis of Experimental Model for Study of Adhesions After Incisional Hernias Induced in Rats’ and Repair of Abdominal Wall With Different Biomaterials

“…Environmental factors such as smoking, factors that are inherent to the patient as obesity and genetics, as well as local complications of the incision, with wound infection, are important to the development of incisional hernias 13 15 26 . Published articles on the various options of synthetic prostheses used in the repair of such hernias 1 3 9 18 19 22 23 29 show that even the state-of-the-art materials, developed for direct contact with the abdominal cavity, despite decreasing, they can not completely prevent the formation of adhesions on these prostheses 4 22 23 25 , demonstrating that these materials need to be improved. Several experimental studies describe tactics to minimize complications related to adhesions 2 14 20 27 and implanted biomaterials 3 6 16 .…”

“…Some researchers use the repair of defects produced in the abdominal wall to evaluate the biocompatibility of synthetic materials, performing the opening of the linea alba, biomaterial implant, fixation to the peritoneum and suture 11 18 or not of the muscles in different ways 1 3 16 19 24 . Another option would be to resect fragments of the abdominal wall in various shapes: rectangular 1 6 23 , triangular 9 , squares 16 , ellipsoids 24 30 , or even defects made laterally to the midline 9 22 28 . Regarding the repair of the defect, it can be made with all the fragments of the prosthesis within the cavity 3 9 6 11 19 21 30 or just suturing the edges in a "bridge" shape 1 6 16 22 23 24 , tactic used in this research.…”

“…Biomaterial implants in the abdominal wall allowed the development of classical experimental models for the study of its biocompatibility. They can be basically divided on: 1) those which an incision is made with standard size on the linea alba and its repair is made with different prostheses in the first operation 11 19 21 ; 2) on those that resect fragments with various formats of the wall 9 22 23 30 and also perform primary repair 1 10 29 ; and on 3) those whose model is similar to the usual clinical condition, initially producing an incisional hernia, with its subsequent correction 4 . The focus of these studies is the consequence of the synthetic implants directly in contact with the abdominal viscera, a topic that has gained importance with the development of laparoscopy as an option for treating ventral hernias 5 16 18 25 .…”

“…The incisional hernia is a common complication after conventional abdominal operations, occurring mainly in smokers, obese or after surgical wound infection 5 13 26 and its correction is usually performed with synthetic prostheses. The biomaterials used for this purpose must be inert, have good resistance and trigger small inflammatory response at the site where they have been implanted to be properly integrated to the tissues 22 23 . When repaired with conventional technique, polypropylene is often used, due to easy handling and low cost, but this material can not stay in contact with the abdominal contents, because it may cause the formation of adhesions and the risk of an intestinal obstruction or enteric fistulae 6 18 25 .…”