Comparative Study if Coagulation Factors in Pre-Eclampsia and Normal Pregnancy

Dave, Rutvi Gautam; Agravat, Amit H; Dhruva, Gauravi; Katara, Ankita A.

doi:10.15373/22778179/apr2014/135

Cited by 4 publications

(7 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study plasma fibrin degradation product (FDP) was higher in preeclamptic women than healthy non pregnant female. This result is similar to other authors 6,[9][10][11][12]15 .…”

Section: Discussionsupporting

confidence: 93%

“…In the present study, mean plasma fibrinogen level was higher inpreeclamptic women than healthy nonpregnant female.This finding was in agreement with those of different researchers of different countries 9,10 . But some investigators did not find significant difference of plasma fibrinogen level between preeclamptic women and healthy non pregnant female 6,11 .…”

Section: Discussionmentioning

confidence: 96%

“…Several studies showed increased serum fibrinogen and FDP in patients with severe preeclampsia9,10. But some studies found low serum fibrinogen level in severe preeclampsia 6,11,12 .…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Plasma Fibrinogen and Fibrin Degradation Product (FDP) in Preeclampsia

Sultana¹,

Nargis²,

Roy³

et al. 2019

Med. Today

View full text Add to dashboard Cite

2) late onset preeclampsia (after 34 wks gestation) 5 .Preeclampsia creates a functional derangement of multiple organ system. Complications of preeclampsia include eclampsia, placental abruption, ascities, hepatic infarction and rupture, intra-abdominal bleeding, pulmonary edema and acute renal failure. Twenty percent (20%) of women with severe preeclampsia develops HELLP syndrome (hemolysis, elevated liver enzymes, low platelets) and the same percentage (20%) among HELLP syndrome develops disseminated intravascular coagulation (DIC). Complications affecting the developing fetus include intrauterine growth retardation, prematurity, oligohydramnios, bronchopulmonary dysplasia and increased risk of perinatal death 2 . During normal pregnancy profound changes occur in the coagulation and fibrinolytic system of the mother causing a hypercoagulable state. In preeclampsia there is a distinct possibility of accentuation of this hypercoagulable state of pregnancy 4 .Numerous studies observed coagulation abnormalities in preeclampsia. The level of anticoagulants such as antithrombin III, protein C and protein S are decreased in these groups. The clotting factors such as factor VIII and von Willebrand factors are elevated in preeclampsia. There is also increase in plasminogen activator inhibitor type 1(PAI-1) in preeclampsia. So preeclampsia is a highly thrombotic and procoagulant state 1 .Fibrinogen is the primary blood clotting factor. Fibrin clot is formed from fibrinogen. Fibrinogen plays a vital role in the process of inflammation, atherogenesis and thrombogenesis. Fibrinogen is a cofactor in platelet activation and may directly contribute to platelet plaque

show abstract

“…In this study plasma fibrin degradation product (FDP) was higher in preeclamptic women than healthy non pregnant female. This result is similar to other authors 6,[9][10][11][12]15 .…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Plasma Fibrinogen and Fibrin Degradation Product (FDP) in Preeclampsia

Sultana¹,

Nargis²,

Roy³

et al. 2019

Med. Today

View full text Add to dashboard Cite

show abstract

“…Similarly the significant prolongation of aPTT in severe pre eclampsia occurs due to activation and consumption of coagulation factors [1,16] especially factor VIII. [2] The significant decrease in mean fibrinogen level in cases of pre eclampsia and eclampsia as compared to that in the controls have also been observed by Srivastava et al (1995) [8] , Acmaz et al (2008) [3] , Jahromi and Rafiee (2009) [7] and Dave et al (2014) [17] , similar to the present findings. The changing levels of fibrinogen in pre eclampsia were explained by various authors as under-(1) Preeclampsia is a systemic inflammation and fibrinogen being an acute phase reactant, is increased in response to inflammation.…”

Section: Discussionsupporting

confidence: 90%

“…[3] (3) In pre eclampsia patients, the coagulationfibrinolytic system is thought to be one of the most seriously affected systems by maternal inflammatory reactions and immune dysfunction. [16] Srivastava et al (1995) [8] , Jahromi and Rafiee (2009) [7] and Dave et al (2014) [17] also found significantly higher levels of FDP in cases as compared to controls, similar to the present findings. D-dimer (FDP) is a specific degradation product resulting from the hydrolysis of the fibrin monomer and is considered to be an indirect marker for thrombosis and fibrinolytic activity.…”

Section: Discussionsupporting

confidence: 88%

Study of Coagulation Profile and Platelet Counts in Pre Eclamptic and Eclamptic Patients

Agrawal¹

2019

jmscr

View full text Add to dashboard Cite

We conducted this prospective case-control study in rural population based medical institute of central India. The aim of the study was to assess and analyze the coagulation profile (PT, aPTT, fibrinogen and fibrin degradation product [FDP] levels) and platelet counts in 3 rd trimester normotensive, pre-eclamptic and eclamptic pregnant women. Methods: In all subjects (cases and controls) 2 ml of blood sample was collected in EDTA and tri-sodium citrate bulbs for platelet counts and coagulation profile respectively. Results: The mean PT and aPTT were significantly high in cases and mean fibrinogen level was significantly low in cases as compared to controls. FDP was significantly increased in cases as compared to non-detectable level in the controls. Thrombocytopenia was observed in 45% of cases. No any correlation between level of platelet count and abnormal coagulation test results (PT, aPTT, fibrinogen and FDP) were found. Conclusion:We found in our study that platelet count and above coagulation tests should be performed in cases of pre eclampsia and eclampsia to identify severity of disease and to prevent development of complications.

show abstract

Bleeding Time and Clotting Time in Pre-eclampsia, Eclampsia and Normal Pregnancy

Sultana,

Islam,

Afroz

et al. 2024

Med. Today

View full text Add to dashboard Cite

Introduction: The most important cause of maternal and perinatal morbidity and mortality are hypertensive disorder (Preeclampsia and eclampsia). In preeclampsia and eclampsia there is hypercoagulable state which acts as a risk factor for thromboembolism and DIC. Objective: This study was carried out to compare the coagulation indices in normal pregnancy, preeclampsia and eclampsia. Materials and Methods: This cross sectional study was conducted in Dhaka Medical College from January to December’ 2014. Total 150 women aged 18 – 40 years were selected for this study. Among them 50 normal pregnant, 50 preeclamptic and 50 eclamptic women were selected as study group and age matched 50 healthy nonpregnant women were considered as control group. Bleeding time was estimated by Duke’s method and clotting time was estimated by capillary tube method. Results: In this study bleeding time and clotting time were significantly higher in preeclamptic and eclamptic women than those of healthy nonpregnant women. Conclusion: From this study it can be concluded that bleeding time and clotting time are closely related with preeclampsia and eclampsia. Medicine Today 2023 Vol.36 (1): 41-44

show abstract

Comparative Study if Coagulation Factors in Pre-Eclampsia and Normal Pregnancy

Cited by 4 publications

References 1 publication

Plasma Fibrinogen and Fibrin Degradation Product (FDP) in Preeclampsia

Plasma Fibrinogen and Fibrin Degradation Product (FDP) in Preeclampsia

Study of Coagulation Profile and Platelet Counts in Pre Eclamptic and Eclamptic Patients

Bleeding Time and Clotting Time in Pre-eclampsia, Eclampsia and Normal Pregnancy

Contact Info

Product

Resources

About