Comparative study of anti-inflammatory activities of whole plant and fruit extracts of Fragaria vesca in experimental animal models

Abstract

Background: Fragaria vesca has been used in the past for the treatment of rheumatism and gout. Material and Methods: Ethanolic extracts of fruits and the whole plant of F. vesca were prepared by the percolation method and oral toxicity testing was performed as per Organization for Economic Co-operation and Development (OECD) guidelines. The antiinfl ammatory activity against acute infl ammation was checked by the carrageenan-induced rat paw edema test, the granuloma pouch method for the subacute infl ammation, and Freund's adjuvant-induced arthritis model for chronic infl ammation in albino rats. The fruit extract was used at a dose of 500 mg/kg and the whole plant extract was also used at 500 mg/kg. Aspirin (100 mg/kg) was taken as standard. Results: The fruit extract, whole plant extract, and aspirin, all showed signifi cant anti-infl ammatory activities against acute,subacute, and chronic infl ammation as compared to the control (P < 0.01) although the fruit extract showed a better activity than the whole plant extract (P < 0.05). Conclusion: F. vesca showed a signifi cant activity against acute, sub acute, and chronic infl ammation. Anti-infl ammatory activities of all the drugs in a decreasing order were as follows: aspirin > fruit extract, 500 mg/kg > whole plant extract, 500 mg/kg.

The Analgesic, Anti-Inflammatory and Anti-Pyretic Activities of Tinospora cordifolia

“…It has been reported that inflammation is a response to many physiological conditions, such as infection, thermal and/or physical injuries [27]. The inflammatory response is necessary for survival against environmental pathogens and injuries.…”

“…The inflammatory response is necessary for survival against environmental pathogens and injuries. Pain, fever and inflammation are not considered major diseases, but are common clinical manifestations associated with many fatal diseases [27]. Inflammation plays a crucial role in the pathogenesis of many auto-immune diseases [28][29][30][31][32][33].…”

“…Plant-based medicines are often considered to have minimal side effects and have the potential to treat many life-threatening diseases [43][44][45]. Recently, many plants have been reported to have analgesic, anti-inflammatory and antipyretic activities, including Fragaria vesca [27], Mimusops elengi linn [46], Melanthera scandens [47] and Caesalpinia decapetala [48].…”

Analgesic, anti-inflammatory and anti-pyretic activities of Caesalpinia decapetala

“…Inflammatory response is necessary for the survival against environmental pathogens and harms. 21 Inflammation is categorized into five cardinal signs which are known as redness, swelling, heat, pain and loss of function. 22 Prostaglandins are produced by the cells which are involved in the production of pain, fever and inflammation.…”

“…Natural medicine and herbs are considered to have minimum side effects and invite the scientists and researchers to find a natural medicine in order to treat pain, inflammation and pyrexia. Many plants such as Fragaria vesca, 21 Mimusops elengi linn, 22 and Melanthera scandens have recently been reported to possess analgesic, anti-inflammatory and antipyretic activities. 38 Preliminary phytochemical studies showed the presence of flavonoids and terpinoids which led to the investigation of analgesic, anti-inflammatory and antipyretic activities of C.decapetala .…”