Artificial neural networks are mathematical models of artificial intelligence that intend to reproduce the behavior of the human brain and whose main objective is the construction of systems that are capable of demonstrating certain intelligent behavior. The purpose of the investigation is to determine the influence of the use of Information and Communication Technologies (ICTs) in the digital culture in the learning process of university students in Peru and Bolivia in the context of the Coronavirus -COVID 19 sanitary emergency, through the application of artificial neural network models. The investigation has a quantitative focus, the applied type, with a correlational level and a non-experimental design. Data was recollected by means of a digital questionnaire, applied to students of two universities. The population is composed of 3980 students of the Universidad Privada Domingo Savio (UPDS, Tarija, Bolivia) and 1506 of the Universidad Nacional de Moquegua (UNAM, Moquegua, Peru). The sample consists of 496 students. The hypothetical-deductive and the artificial intelligence methods were used. It was determined that the ability to install software and data protection programs, the use of mobile devices for academic purposes and the command of specialized software are the most influential factors in the digital culture of the students at UNAM and UPDS.