Comparative study of dietary fat: lard and sugar as a better obesity and metabolic syndrome mice model

Guimarães, Victor Hugo Dantas; Lelis, Deborah de Farias; Oliveira, Luis Paulo; Borém, Luciana Mendes Araújo; Guimarães, Felipe Alberto Dantas; Farias, Lucyana Conceição; Paula, Alfredo Maurício Batista de; Guimarães, André Luiz Sena; Santos, Sérgio Henrique Sousa

doi:10.1080/13813455.2020.1835986

Cited by 26 publications

(10 citation statements)

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“…Further examination of parameters of glucose homeostasis revealed significantly disturbed glucose utilization solely in the DIO group while HFD and WSD displayed only moderate effects. These findings are consistent with the results of Guimarães and colleagues [ 19 ] in which an increased glucose tolerance was observed only in the high-lard, high-sugar (HLHS) group while the high-butter, high-sugar group (HBHS) did not deviate from the SD group significantly. In order to determine the underlying causes it seems to be necessary to take a closer look on the individual lipid profile.…”

Section: Discussionsupporting

confidence: 93%

“…Considering a similar dietary fat content (23,6%, DIO / 22,0% WSD) but different amounts of sugar (21.1%, DIO / 34.4%, WSD) the observed phenotype must result either from the fat quality (lard (HFD & DIO) vs. butter fat (WSD)) and/or from the varying combinations of fat plus sugar. Along with the present findings, recently Guimarães et al described the combination of high-lard/high-sugar being more efficient in inducing obesity and glucose intolerance compared to high-butter/high-sugar or high-oil/high-sugar [ 19 ]. In contrast to Guimaraes’s study, our setup also included a high-fat/normal-sugar diet (HFD) which was frequently used in previous studies [ 9 , 17 , 45 ].…”

Section: Discussionsupporting

confidence: 85%

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Heterogeneous effects of individual high-fat diet compositions on phenotype, metabolic outcome, and hepatic proteome signature in BL/6 male mice

et al. 2023

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The multitude of obesogenic diets used in rodent studies can hardly be overviewed. Since standardization is missing and assuming that individual compositions provoke individual effects, the choice of quality, quantity and combination of diet ingredients seems to be crucial for the outcome and interpretation of obesity studies. Therefore, the present study was conducted to compare the individual effects of three commonly used obesogenic diets, mainly differing in sugar and fat content. Besides basic phenotypic and metabolic characterization, one main aspect was a comparative liver proteome analysis. As expected, the obtained results picture differentiated consequences mainly depending on fat source and/or fat- and sugar quantity. By confirming the general presumption that the choice of nutritional composition is a pivotal factor, the present findings demonstrate that a conscious selection is indispensable for obtaining reliable and sound results in obesity research. In conclusion, we strongly recommend a careful selection of the appropriate diet in advance of a new experiment, taking into account the specific research question.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 85%

Heterogeneous effects of individual high-fat diet compositions on phenotype, metabolic outcome, and hepatic proteome signature in BL/6 male mice

et al. 2023

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“…A previous study showed that excessive consumption of yolk egg, containing very high cholesterol, induces obesity and dyslipidaemia [13]. Foods enriched with lard and sugar also result in induction obesity with high levels of CHO and TG [14].…”

Section: Discussionmentioning

confidence: 97%

The Comparative Effects of Branded and Local High Fat Foods on Body Mass Index and Vascular Wall Thickness in Male Wistar Rats for Development of Atherosclerosis Animal Model

Putro¹,

Indarto²,

Purwanto³

et al. 2022

Proceedings of the 4th International Conference on Life Sciences and Biotechnology (ICOLIB 2021)

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Cardiovascular diseases are the leading cause of mortality over the world, which is approximately 17.9 million patients' death in 2019 or 32% of all deaths worldwide. Atherosclerosis formation due to accumulated plaques in the tunica intima of vascular walls underlies the pathogenesis of cardiovascular diseases. Inactive life style and bad diet are the major risk factors of these diseases. This study investigated the different effect of high-fat diets on body mass index (BMI), lipid profile and vascular wall thickness (VWT) in rats model atherosclerosis. A total of 10 male Wistar rats were used in this experimental study. The Wistar rats were randomly divided into two groups (A and B). Group A was fed by the DYETs food while group B were given local high fat foods. The BMI was calculated using body weight (BW) and body length. Internal carotid artery thickness was measured using a linear ultrasound. The t-tests were performed to compare within and between groups. There was a significant difference in carotid artery thickness between two groups with p < 0.05 but the mean BMI of group A did not differ from the mean BMI of group B with p > 0.05. In conclusion, A local high fat diet has a similar effect in obesity induction of male Wistar rats, compared to DYETs diet although a higher increased internal carotid artery thickness is detected in the later diet. Further research is required to identify histopathologically the plaque structure.

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“…Long term HFD caused an increase in the volume and size of the adipose tissue, whereas a high-sucrose diet induced severe glucose intolerance in both obese and lean mice [ 14 ]. Moreover, a high-lard diet induced a more severe metabolic disorder than a high-butter diet in mice [ 41 ]. Furthermore, a difference in the composition of the diet can affect the microbiota–host interactions; for instance, dietary cholesterol was associated with diet-induced obesity resistance in germ-free mice [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

AB-Kefir Reduced Body Weight and Ameliorated Inflammation in Adipose Tissue of Obese Mice Fed a High-Fat Diet, but Not a High-Sucrose Diet

Chen¹,

Hsu²,

Chiou³

et al. 2021

Nutrients

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Consumption of different types of high-calorie foods leads to the development of various metabolic disorders. However, the effects of multi-strain probiotics on different types of diet-induced obesity and intestinal dysbiosis remain unclear. In this study, mice were fed a control diet, high-fat diet (HFD; 60% kcal fat and 20% kcal carbohydrate), or western diet (WD; 40% kcal fat and 43% kcal carbohydrate) and administered with multi-strain AB-Kefir containing six strains of lactic acid bacteria and a Bifidobacterium strain, at 109 CFU per mouse for 10 weeks. Results demonstrated that AB-Kefir reduced body weight gain, glucose intolerance, and hepatic steatosis with a minor influence on gut microbiota composition in HFD-fed mice, but not in WD-fed mice. In addition, AB-Kefir significantly reduced the weight and size of adipose tissues by regulating the expression of CD36, Igf1, and Pgc1 in HFD-fed mice. Although AB-Kefir did not reduce the volume of white adipose tissue, it markedly regulated CD36, Dgat1 and Mogat1 mRNA expression. Moreover, the abundance of Eubacterium_coprostanoligenes_group and Ruminiclostridium significantly correlated with changes in body weight, liver weight, and fasting glucose in test mice. Overall, this study provides important evidence to understand the interactions between probiotics, gut microbiota, and diet in obesity treatment.

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Comparative study of dietary fat: lard and sugar as a better obesity and metabolic syndrome mice model

Cited by 26 publications

References 69 publications

Heterogeneous effects of individual high-fat diet compositions on phenotype, metabolic outcome, and hepatic proteome signature in BL/6 male mice

Heterogeneous effects of individual high-fat diet compositions on phenotype, metabolic outcome, and hepatic proteome signature in BL/6 male mice

The Comparative Effects of Branded and Local High Fat Foods on Body Mass Index and Vascular Wall Thickness in Male Wistar Rats for Development of Atherosclerosis Animal Model

AB-Kefir Reduced Body Weight and Ameliorated Inflammation in Adipose Tissue of Obese Mice Fed a High-Fat Diet, but Not a High-Sucrose Diet

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