The expansion of urban areas towards the development of new urban areas has an impact on changes in land use, socio-economic dynamics and a decrease in environmental quality. This study aims to analyze land use change as a determinant of environmental degradation and the spatial dynamics of metropolitan urban areas, the effect of land use change, housing development, infrastructure development, and land reclamation on the environmental degradation of the new city area, and control strategies environmental pollution and sustainable development of the new city area. This study uses a quantitative-qualitative concurrent triangulation design approach. Elaboration of data through observation, in-depth interviews, surveys, and documentation is used to describe the socio-economic community, and the decline in the environmental quality of new city area development in relation to the spatial dynamics of metropolitan urban areas. The results of the study show that the intensity of land use change coupled with an increase in socio-economic activities in the development of new city areas is positively associated with a decrease in environmental quality and segregation towards the spatial dynamics of metropolitan urban areas. Changes in land use, housing development, infrastructure development, and land reclamation simultaneously affect environmental quality degradation with a coefficient of determination of 64.96%. This study recommends strategies for controlling environmental pollution and sustainable development of new city areas for the needs of formulating urban development policies for Mamminasata Metropolitan South Sulawesi, Indonesia.