Comparative study of membranotropic action of single- and multi-walled carbon nanotubes

Prylutska, Svitlana; Bilyy, Rostyslav; Shkandina, Tatiana; Rotko, Daria; Bychko, A.; Черепанов, В. М.; Stoika, Rostyslav; Rybal’chenko, V. K.; Prylutskyy, Yu. І.; Tsierkezos, Nikos G.; Ritter, Uwe

doi:10.1016/j.jbiosc.2012.12.016

Cited by 21 publications

(19 citation statements)

References 31 publications

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“…The contaminants such as amorphous carbon and metallic catalyst particles were removed after a treatment with boiling HCl (6 M) in a reflux condenser. According to the electron microscopic micrographs [SEM and TEM data (Prylutska et al 2013)], the diameter and the length of SWCNTs were 0.5-2 nm and 1-5 lm, respectively.…”

Section: Swcntsmentioning

confidence: 99%

“…Applications have appeared in molecular electronics (Avouris 2002;Cao et al 2013;Ogloblya et al 2010), nanobiotechnology (Andreichenko et al 2012;Ge et al 2011;Liu et al 2009a;Prylutska et al 2013), biosensorics (Ogloblya et al 2009;Panchapakesan et al 2012;Wang et al 2003), cancer therapy (Ali-Boucetta et al 2008;Adeli et al 2013;Burlaka et al 2010;Liu et al 2009b) etc.…”

Section: Introductionmentioning

confidence: 99%

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Complexation of aromatic drugs with single-walled carbon nanotubes

et al. 2014

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We report a detailed study of the complexation of aromatic molecules and drugs with the surface of single-walled carbon nanotubes (SWCNTs, the diameter and the length ranges are 0.5-2 nm and 1-5 lm, respectively) in terms of equilibrium binding constants, K. It is found that the binding constants have magnitudes of the order of 10 4 -10 5 M -1 and that there is some ligand specificity to the SWCNT surface depending on the structure of the aromatic molecule. The observed specificity is strongly governed by the curvature of the ligand chromophore and the type of side chains, resulting in the highest K for methylene blue which closely matches the curvature of the SWCNT surface. Stabilization of the drug-SWCNT complexes is found to be mainly due to intermolecular van der Waals forces and to a lesser extent by hydrophobic interactions. The approach suggested for determination of the binding parameters may be used as an alternative, or complementary, to standard Langmuir analysis.

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Section: Swcntsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Complexation of aromatic drugs with single-walled carbon nanotubes

et al. 2014

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“…These findings are wellcorresponded with the previously obtained data about the capability of the Fe-MWCNTs to form channels in the cell plasma membrane. SWCNTs and MWCNTs also are capable of forming channels or other types of local defects but with a significant delay if compared with the Fe-MWCNTs, probably due to the weaker surface charge and possibility of weak interactions caused by the presence of iron atoms [7]. Carbon nanoparticles in the concentration of 10 μg ּ◌ml -1 doesn't show any significant effect on the dynamics of the acidinduced hemolysis (Fig.…”

Section: Effect Of Carbon Nanoparticles On Dynamics Of Acidic Hemolysismentioning

confidence: 97%

“…We have shown, that all of the nanoparticles cause the externalization of phosphatidylserine (PS) from the inner (where it is normally located) to the outer leaflet plasma membrane, which can be detected with the use of annexin-V-FITC. Moreover, we have shown that the externalization of the PS takes place only in the small local patches and results in the cell membrane swelling and the accretion of the cell volume [6][7][8]. In current study we are making an attempt to give some insights on the mechanism of carbon nanoparticle-cells interaction and compare the effects of the different types of nanoparticles (C 60 fullerenes, SWCNTs, MWCNTs and Fe-MWCNTs) on human blood cells.…”

Section: Introductionmentioning

confidence: 96%

The interaction of the carbon nanoparticles with human cell plasma membrane

et al. 2013

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The study of carbon nanostructures is a highly topical branch of bionanotechnology because of their potential application in biomedicine. Carbon nanotubes (CNTs) are known for their ability to kill tumor cells causing hyperthermia shock and can be used in photothermal therapy respectively. Also chemically modified CNTs can be used for drug delivery. The needle-like shape of CNTs allows them to penetrate into the cell plasma membrane without killing the cell. C 60 fullerenes are regarded as valuable nanocarriers for different hydrophobic molecules as well as potential antiviral agents or photosensitizers.In our previous studies we have demonstrated that all types of carbon nanoparticles cause externalization of phosphatidylserine (PS) from the inner to the outer layer of the cell membrane in the small local patches (points of contact), leaving the other parts of plasma membrane PS-negative. In the current work there were studied the interactions of pristine C 60 fullerenes and different types of CNTs with human blood cells (erythrocytes and Jurkat T-cells). We have shown, that carbon nanoparticles do not have any hemolytic effects, if judged by the dynamics of acidic hemolysis, although they are capable of permeabilizating the cells and facilitating the internalization of propidium iodide into the nuclei.

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“…Carbon nanotubes (CNTs) are expected to achieve a breakthrough in the treatment of breast cancer and other tumors by reducing the tumors' resistance to radiotherapy and chemotherapy [5]–[7]. Functional CNTs have a potential for protein and gene transfer across the cell membrane and into the nucleus [8]–[17].…”

Section: Introductionmentioning

confidence: 99%

Oxygen-Carbon Nanotubes as a Chemotherapy Sensitizer for Paclitaxel in Breast Cancer Treatment

Wang

Jia

et al. 2014

PLoS ONE

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ObjectiveTo study the in vivo and in vitro effects of adding oxygen carbon nanotubes (CNTs) to chemotherapy for breast cancer.MethodsMCF-7 and SK-BR-3 breast cancer cells were co-cultured with paclitaxel and then exposed to oxygen-CNTs under hypoxic conditions. Cell proliferation, viability, and apoptosis rate were analyzed. Hypoxia-inducible factor-1 alpha (HIF-1α) expression was measured using reverse transcription-polymerase chain reaction (RT-PCR) and western blot. Nude mice were used as a human breast cancer model to explore the impact of oxygen-CNTs on the in vivo chemotherapeutic effect of paclitaxel.ResultsOxygen-CNTs had no significant effects on the growth of breast cancer cells under normoxia and hypoxia. However, in the hypoxic environment, oxygen-CNTs significantly enhanced the inhibitory effect of paclitaxel on cell proliferation, as well as the apoptosis rate. Under hypoxia, downregulation of HIF-1α and upregulation of caspase-3, caspase-8, caspase-9, LC3 and Beclin-1 were observed when paclitaxel was combined with oxygen-CNT. Furthermore, addition of oxygen-CNTs to chemotherapy was found to significantly reduce tumor weight in the tumor-bearing mice model.ConclusionsOxygen-CNTs can significantly increase the chemotherapeutic effect of paclitaxel on breast cancer cells. Oxygen-CNTs may be a potential chemosensitizer in breast cancer therapy.

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Comparative study of membranotropic action of single- and multi-walled carbon nanotubes

Cited by 21 publications

References 31 publications

Complexation of aromatic drugs with single-walled carbon nanotubes

Complexation of aromatic drugs with single-walled carbon nanotubes

The interaction of the carbon nanoparticles with human cell plasma membrane

Oxygen-Carbon Nanotubes as a Chemotherapy Sensitizer for Paclitaxel in Breast Cancer Treatment

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