Comparative Study of Ocular Herpes Simplex Virus in Patients With and Without Self-Reported Atopy

Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis

“…Diabetes (Kaiserman 2005), atopy (Rezende 2006), and immunosuppression are suggested to result in slower resolution. Health status was not considered in the studies included in this review.…”

“…Herpetic recurrences may become more common with ageing (Young 2010). HSV epithelial keratitis may be more prevalent or severe in atopes, corneal transplant recipients, patients using corticosteroids (Williams 1977), people with immune suppression (Hodge 1997; Kaiserman 2006; Prabriputaloong 2006; Remeijer 1997; Rezende 2006), and malnourished children with measles (Ukety 1991). …”

Development of Herpes Simplex Virus Infectious Epithelial Keratitis During Oral Acyclovir Therapy and Response to Topical Antivirals

“…6,7 Additionally, the adult patient had a history of atopy, which has also been associated with more severe and recurrent HSV disease. 8,9 These cases demonstrate the potential for ocular HSV infectious disease progression despite treatment with oral antiviral therapy.…”

Herpetic Simplex Eye Disease in the Pediatric Population

“…15 This can occur under patients with atopy or immune deviation, but is possible to occur without any immune deficits. 20,21 The resultant sequela similar to neonatal herpes can lead to a residual corneal opacity and possible amblyopia. 15,22 In the Herpetic Eye Disease Study, adult patients were followed for 18 months.…”