Comparative study of pharmacological activity of birch bark ethanol extracts

Rapp, O. A.; Pashinskii, V. G.; Chuchalin, V. S.

doi:10.1007/bf02508405

Cited by 3 publications

(4 citation statements)

References 1 publication

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“…The results obtained on the mucous stomach membrane showed that 40% ethanol solution was the best extractant. The birch bark extract thus obtained showed reliable anti-stress and anti-ulcer effects [37].…”

Section: Gastroprotective Activitymentioning

confidence: 97%

“…Different experimental models of ulcer have shown that several mechanisms of action can be involved in the gastrointestinal effects of flavonoids, such as the capture of free radicals, chelation of transition metal ions, the improvement of the enzyme oxidase activity and changes in the levels of protein and non-protein SH compounds, as well as the inhibition of lipid peroxidation. Several flavonoids have shown antiinflammatory properties, without any ulcerative side effect, which is a great advantage in the treatment of peptic ulcer [36,37].…”

Section: Gastroprotective Activitymentioning

confidence: 99%

“…In the study of Rapp et al [37], the gastroprotective activity of various concentrations of common birch bark aqueous-ethanolic extracts (20,30,35, 40 and 70%) was investigated. The results obtained on the mucous stomach membrane showed that 40% ethanol solution was the best extractant.…”

Section: Gastroprotective Activitymentioning

confidence: 99%

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Common birch (Betula pendula Roth.): Chemical composition and biological activity of isolates

Vladimirov¹,

Nikolić²,

Stanojevic³

et al. 2019

Adv Techol

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The common birch (Betula pendula Roth., Betulaceae) is widespread in moderate and northern climatic zones. It is used in traditional medicine of many countries, and its positive effects on human health were recognized a long time ago. It belongs to a group of medicinal plants. Numerous studies on the chemical composition and activity of the birch isolates are aimed at confirming their biological effects and the use in traditional medicine. A large number of bioactive compounds have been isolated from buds, juice (sap), leaves and bark of common birch. The composition varies depending on the variety, age of the plant, geographical area, the methods of isolation and the analysis used. However, the chemical composition of the isolates has been partially studied, and further investigations are required. Anti-inflammatory, antimicrobial, antiviral, antioxidant, antiproliferative, antirheumatoid, uteroprotective, antiallergic and gastroprotective activity of the isolates have been established. That opens the possibility of its potential use in the prevention and treatment of a wide spectrum of diseases. Further preclinical and clinical studies are needed in order to create and apply preparations based on common birch isolates.

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Section: Gastroprotective Activitymentioning

confidence: 97%

Section: Gastroprotective Activitymentioning

confidence: 99%

See 1 more Smart Citation

Common birch (Betula pendula Roth.): Chemical composition and biological activity of isolates

Vladimirov¹,

Nikolić²,

Stanojevic³

et al. 2019

Adv Techol

View full text Add to dashboard Cite

show abstract

“…The bioactivities of Betula species are well documented, in fact the Betula was largely used in human and veterinary medicine to treat various diseases. Betula compounds have a wide variety of properties including anticancer, anti-inflammatory, and immunomodulatory beyond being antioxidant [9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Betula etnensis Raf. (Betulaceae) Extract Induced HO-1 Expression and Ferroptosis Cell Death in Human Colon Cancer Cells

Malfa

Tomasello

Acquaviva

et al. 2019

IJMS

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Betula etnensis Raf. (Birch Etna) belonging to the Betulaceae family grows on the eastern slope of Etna. Many bioactive compounds present in Betula species are considered promising anticancer agents. In this study, we evaluated the effects of B. etnensis Raf. bark methanolic extract on a human colon cancer cell line (CaCo2). In order to elucidate the mechanisms of action of the extract, cellular redox status, cell cycle, and heme oxygenase-1 (HO-1) expression in ferroptosis induction were evaluated. Cell viability and proliferation were tested by tetrazolium (MTT) assayand cell cycle analysis, while cell death was evaluated by annexin V test and lactic dehydrogenase (LDH) release. Cellular redox status was assessed by measuring thiol groups (RSH) content, reactive oxygen species (ROS) production, lipid hydroperoxide (LOOH) levels and (γ-glutamylcysteine synthetase) γ-GCS and HO-1 expressions. The extract significantly reduced cell viability of CaCo2, inducing necrotic cell death in a concentration-depending manner. In addition, an increase in ROS levels and a decrease of RSH content without modulation in γ-GCS expression were detected, with an augmentation in LOOH levels and drastic increase in HO-1 expression. These results suggest that the B. etnensis Raf. extract promotes an oxidative cellular microenvironment resulting in CaCo2 cell death by ferroptosis mediated by HO-1 hyper-expression.

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Antimicrobial and antioxidant properties ofBetula aetnensisRafin. (Betulaceae) leaves extract

Acquaviva

Menichini

Ragusa

et al. 2013

Natural Product Research

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This study aimed to evaluate the antimicrobial effects, the radical scavenging activity (by DPPH and ABTS tests) and the antioxidant capacity (by β-carotene bleaching test) of Betula aetnensis leaves extract. The antimicrobial activity was tested against 14 Gram-positive clinical strains, 2 ATCC Gram-positive strains, 10 Gram-negative clinical strains and 4 Gram-negative ATCC strains. Streptococcus pyogenes Ery-S and Ery-R1 were the most sensitive. Betula aetnensis was considerably active against three bacterial strains, namely Haemophilus influenzae ATCC 49247, Amp-R1 and Moraxella catarrhalis ATCC 25238. Standard ATCC strains of Gram-positive bacteria were more sensitive than Gram-negative. Betula aetnensis showed also an interesting reducing power with TEAC values of 9.7 and a good inhibition of linoleic acid oxidation with an IC50 value of 22.0 µg mL(-1) after 30 min of incubation. The total phenol and flavonoid contents were determined with the purpose to evaluate the relationship with the observed bioactivities.

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Comparative study of pharmacological activity of birch bark ethanol extracts

Cited by 3 publications

References 1 publication

Common birch (Betula pendula Roth.): Chemical composition and biological activity of isolates

Common birch (Betula pendula Roth.): Chemical composition and biological activity of isolates

Betula etnensis Raf. (Betulaceae) Extract Induced HO-1 Expression and Ferroptosis Cell Death in Human Colon Cancer Cells

Antimicrobial and antioxidant properties ofBetula aetnensisRafin. (Betulaceae) leaves extract

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