Comparative study of pineal clock gene and AANAT2 expression in relation to melatonin synthesis in Atlantic salmon (Salmo salar) and European seabass (Dicentrarchus labrax)

McStay, Elsbeth; Migaud, Hervé; Vera, Luisa María; Sánchez-Vázquez, F.J.; Davie, Andrew

doi:10.1016/j.cbpa.2013.12.011

Cited by 28 publications

(19 citation statements)

References 49 publications

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“…Among the 3 period genes expressed in Chinese perch slow muscles, their dark-biased expression was in agreement with that reported from other fish species, such as goldfish, European sea bass and zebrafish [20, 28, 36, 37]. On the other hand, their light-biased expression in Chinese perch fast muscle is also consistent with the central and peripheral clocks in Senegalese sole [24].…”

Section: Discussionsupporting

confidence: 87%

Daily rhythmicity of clock gene transcript levels in fast and slow muscle fibers from Chinese perch (Siniperca chuatsi)

Cheng

et al. 2016

BMC Genomics

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BackgroundClock genes are considered to be the molecular core of biological clock in vertebrates and they are directly involved in the regulation of daily rhythms in vertebrate tissues such as skeletal muscles. Fish myotomes are composed of anatomically segregated fast and slow muscle fibers that possess different metabolic and contractile properties. To date, there is no report on the characterization of the circadian clock system components of slow muscles in fish.ResultsIn the present study, the molecular clock components (clock, arntl1/2, cry1/2/3, cry-dash, npas2, nr1d1/2, per1/2/3, rorα and tim genes) and their daily transcription levels were characterized in slow and fast muscles of Chinese perch (Siniperca chuatsi). Among the 15 clock genes, nrld2 and per3 had no daily rhythmicity in slow muscles, and cry2/3 and tim displayed no daily rhythmicity in fast muscles of the adult fish. In the slow muscles, the highest expression of the most clock paralogs occurred at the dark period except arntl1, nr1d1, nr1d2 and tim. With the exception of nr1d2 and tim, the other clock genes had an acrophase at the light period in fast muscles. The circadian expression of the myogenic regulatory factors (mrf4 and myf5), mstn and pnca showed either a positive or a negative correlation with the transcription pattern of the clock genes in both types of muscles.ConclusionsIt was the first report to unravel the molecular clock components of the slow and fast muscles in vertebrates. The expressional pattern differences of the clock genes between the two types of muscle fibers suggest that the clock system may play key roles on muscle type-specific tissue maintenance and function.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-016-3373-z) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 87%

Daily rhythmicity of clock gene transcript levels in fast and slow muscle fibers from Chinese perch (Siniperca chuatsi)

Cheng

et al. 2016

BMC Genomics

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“…In some species, this activity may also be indirectly modulated by other photosensory structures, such as retinal and/or deep brain photoreceptors (Migaud et al 2006, 2007, Choi et al 2016. The pineal gland of teleosts (except salmonids) contains all the necessary elements to be considered a real circadian clock, with the complete core machinery (Cahill 2002, McStay et al 2014. Melatonin secretion may be considered the main output of the pineal clock, which is considered a LEO.…”

Section: Melatoninmentioning

confidence: 99%

“…Its circadian rhythmicity is maintained under both an LD cycle and constant darkness conditions in vivo and in vitro (Bolliet et al 1996, Martinez-Chavez et al 2008. Salmonids are the exception to this, as rhythmic melatonin synthesis does not occur in the absence of an LD cycle (Bolliet et al 1996, McStay et al 2014. A molecular connection between the pineal clockwork and melatonin synthesis has been demonstrated through the existence of an E-box in the aanat2 promoter that binds the Clock-Bmal dimer (Appelbaum et al 2006, Falcón et al 2009, 2010.…”

Section: Melatoninmentioning

confidence: 99%

Interplay between the endocrine and circadian systems in fishes

Isorna

Pedro

Valenciano

et al. 2017

Journal of Endocrinology

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The circadian system is responsible for the temporal organisation of physiological functions which, in part, involves daily cycles of hormonal activity. In this review, we analyse the interplay between the circadian and endocrine systems in fishes. We first describe the current model of fish circadian system organisation and the basis of the molecular clockwork that enables different tissues to act as internal pacemakers. This system consists of a net of central and peripherally located oscillators and can be synchronised by the light-darkness and feeding-fasting cycles. We then focus on two central neuroendocrine transducers (melatonin and orexin) and three peripheral hormones (leptin, ghrelin and cortisol), which are involved in the synchronisation of the circadian system in mammals and/or energy status signalling. We review the role of each of these as overt rhythms (i.e. outputs of the circadian system) and, for the first time, as key internal temporal messengers that act as inputs for other endogenous oscillators. Based on acute changes in clock gene expression, we describe the currently accepted model of endogenous oscillator entrainment by the light-darkness cycle and propose a new model for non-photic (endocrine) entrainment, highlighting the importance of the bidirectional cross-talking between the endocrine and circadian systems in fishes. The flexibility of the fish circadian system combined with the absence of a master clock makes these vertebrates a very attractive model for studying communication among oscillators to drive functionally coordinated outputs.

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“…Likewise, the mechanisms regulating MLT biosynthesis and simultaneously the output of this lipophilic hormone from parenchymal cells vary significantly among species (Maronde and Stehle 2007, Prusik and Lewczuk 2008b, Lewczuk et al 2014b, McStay et al 2014.…”

Section: Introductionmentioning

confidence: 99%

Regulation of melatonin secretion in the pineal organ of the domestic duck – an in vitro study

Prusik¹,

Lewczuk²,

Ziółkowska³

et al. 2015

Polish Journal of Veterinary Sciences

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The aim of study was to determine the mechanisms regulating melatonin secretion in the pineal organs of 1-day-old and 9-month-old domestic ducks. The pineals were cultured in a superfusion system under different light conditions. Additionally, some explants were treated with norepinephrine.The pineal glands of 1-day-old ducks released melatonin in a well-entrained, regular rhythm during incubation under a 12 hrs light : 12 hrs dark cycle and adjusted their secretory activity to a reversed 12 hrs dark : 12 hrs light cycle within 2 days. In contrast, the diurnal changes in melatonin secretion from the pineals of 9-month-old ducks were largely irregular and the adaptation to a reversed cycle lasted 3 days. The pineal organs of nestling and adult ducks incubated in a continuous light or darkness secreted melatonin in a circadian rhythm. The treatment with norepinephrine during photophases of a light-dark cycle resulted in: 1) a precise adjustment of melatonin secretion rhythm to the presence of this catecholamine in the culture medium, 2) a very high amplitude of the rhythm, 3) a rapid adaptation of the pineal secretory activity to a reversed light-dark cycle. The effects of norepinephrine were similar in the pineal organs of nestlings and adults.In conclusion, melatonin secretion in the duck pineal organ is controlled by three main mechanisms: the direct photoreception, the endogenous generator and the noradrenergic transmission. The efficiency of intra-pineal, photosensitivity-based regulatory mechanism is markedly lower in adult than in nestling individuals.

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Comparative study of pineal clock gene and AANAT2 expression in relation to melatonin synthesis in Atlantic salmon (Salmo salar) and European seabass (Dicentrarchus labrax)

Cited by 28 publications

References 49 publications

Daily rhythmicity of clock gene transcript levels in fast and slow muscle fibers from Chinese perch (Siniperca chuatsi)

Daily rhythmicity of clock gene transcript levels in fast and slow muscle fibers from Chinese perch (Siniperca chuatsi)

Interplay between the endocrine and circadian systems in fishes

Regulation of melatonin secretion in the pineal organ of the domestic duck – an in vitro study

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