Comparative Study on Serum Levels of 10 Trace Elements in Schizophrenia

Liu, Tiebing; Lu, Qing‐Bin; Yan, Lailai; Guo, Jian; Feng, Fanchao; Qiu, Jinyun; Wang, Jingyu

doi:10.1371/journal.pone.0133622

Cited by 35 publications

(36 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 75 Much more remains to be learned to fully appreciate the relevance and significance of blood GPx activity along the various stages of the disease. The fact that low level of selenium is a risk factor for schizophrenia 76 supports the need for further studies on GPx in patients. Indeed, GPx are selenium-containing enzymes whose activities depend on this essential micronutrient.…”

Section: Discussionmentioning

confidence: 97%

Impaired fornix–hippocampus integrity is linked to peripheral glutathione peroxidase in early psychosis

et al. 2016

View full text Add to dashboard Cite

Several lines of evidence implicate the fornix–hippocampus circuit in schizophrenia. In early-phase psychosis, this circuit has not been extensively investigated and the underlying mechanisms affecting the circuit are unknown. The hippocampus and fornix are vulnerable to oxidative stress at peripuberty in a glutathione (GSH)-deficient animal model. The purposes of the current study were to assess the integrity of the fornix–hippocampus circuit in early-psychosis patients (EP), and to study its relationship with peripheral redox markers. Diffusion spectrum imaging and T1-weighted magnetic resonance imaging (MRI) were used to assess the fornix and hippocampus in 42 EP patients compared with 42 gender- and age-matched healthy controls. Generalized fractional anisotropy (gFA) and volumetric properties were used to measure fornix and hippocampal integrity, respectively. Correlation analysis was used to quantify the relationship of gFA in the fornix and hippocampal volume, with blood GSH levels and glutathione peroxidase (GPx) activity. Patients compared with controls exhibited lower gFA in the fornix as well as smaller volume in the hippocampus. In EP, but not in controls, smaller hippocampal volume was associated with high GPx activity. Disruption of the fornix–hippocampus circuit is already present in the early stages of psychosis. Higher blood GPx activity is associated with smaller hippocampal volume, which may support a role of oxidative stress in disease mechanisms.

show abstract

Section: Discussionmentioning

confidence: 97%

Impaired fornix–hippocampus integrity is linked to peripheral glutathione peroxidase in early psychosis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Malfunctions related to any of these enzymes due to decreases or increases in Cu may explain the origin of mental illness. Liu et al 33 found lower concentrations of Cu in SCZ serum and they associated such decreases with a risk of SCZ, while Gonzalez‐Estecha et al 34 found higher Cu levels in the serum of BD patients, associating such increases with BD pathophysiology.…”

Section: Resultsmentioning

confidence: 99%

A feasible strategy based on high ultrasound frequency and mass spectrometry for discriminating individuals diagnosed with bipolar disorder and schizophrenia through ionomic profile

Jesus

Arruda

2020

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

Rationale A viable and accurate method based on high‐power ultrasound‐assisted microextraction and inductively coupled plasma mass spectrometry was developed to determine metals in human serum from patients with bipolar disorder and schizophrenia. Methods A simple and rapid sample preparation method using a cup–horn sonoreactor was developed. The acid concentration of HNO3 (10, 20, and 40% v/v) and HCl (1, 5, 15, and 30% v/v) of the extraction solution, the sonication time (1, 3, 6, and 10 min), and the sonication amplitude (20, 40, 60, and 80%) were evaluated. Cd, Cu, Fe, Li, Pb, and Zn were determined in serum samples from patients with bipolar disorder and schizophrenia, and from healthy controls. Quantitative metal recoveries using the proposed method were compared under the same conditions using an ultrasonic bath, magnetic stirring, and microwave‐assisted digestion. Results Optimum extraction conditions were obtained using HNO3 (40% v/v) + HCl (30% v/v) as the extraction solution with 3 min sonication time and 60% sonication amplitude. Significant differences were observed among the methods compared. On application of the sample preparation method based on high‐power ultrasound‐assisted microextraction coupled with inductively coupled plasma mass spectrometry, Pb and Cd in all the studied samples were below the limit of detection of our method. Compared with healthy controls, the concentration of Cu, Li, Fe, and Zn was found to be significantly higher for the bipolar disorder group, while these metals and Li were found at a lower level for the group diagnosed with schizophrenia. Conclusions Principal component analysis showed a significant separation for the groups studied based on their ionomic profiles after the application of high‐power ultrasound‐assisted microextraction as a sample preparation strategy.

show abstract

“…Many studies have shown that dysregulation of Cu adversely influences biological processes of several psychiatric disorders including SZ [21][22][23][24][25][26][27][28][29][30], BD [25,[31][32][33], and MD [25,28,34]. The reduced [28,30,35,36], elevated [21][22][23][26][27][28][29]37,38], and unaltered [25,28,39,40] Cu levels in SZ patients have been mentioned in different studies. Higher Cu concentrations were reported in the course of the BD [41].…”

Section: Discussionmentioning

confidence: 99%

Serum ceruloplasmin-ferroxidase activity in bipolar disorder is elevated compared to major depressive disorder and schizophrenia: a controlled study

Tunç

Atagün

Başbuğ

et al. 2019

Psychiatry and Clinical Psychopharmacology

View full text Add to dashboard Cite

OBJECTIVE: In this study, we aimed to study copper metabolism in schizophrenia, bipolar disorder, major depression compared with healthy control. METHODS: This is a single-centered cross-sectional study. The patients with schizophrenia (n = 36), bipolar disorder (n = 37), major depression (n = 40), and healthy control (n = 32) were included in the study. All participants were initially evaluated by a clinical psychiatrist to confirm the appropriate diagnosis using the Structured Clinical Interview for Diagnostic and Statistical Manuel of Mental Disorders-IV (DSM-IV) Axis I Disorders (SCID-I). Serum copper level, ceruloplasmin mass, and ceruloplasmin-ferroxidase activity were measured. One-way ANOVA and Kruskal-Wallis Tests were performed for statistical analyses. RESULTS: Serum ceruloplasmin-ferroxidase activity (χ 2 = 9.11, p = 0.028) demonstrated a significant statistical difference in all groups compared with the control group. Serum ceruloplasmin-ferroxidase activity of the bipolar disorder group was significantly higher than the healthy control group (p = 0.012), major depression group (p = 0.027), and the schizophrenia group (p = 0.019). Erythrocyte sedimentation rate (ESR) (p = 0.028) and waist circumference (p = 0.005) in bipolar disorder group, and the C-reactive protein (CRP) (p < 0.001) and cholesterol (p = 0.043) in the schizophrenia group were found as the determinants of ceruloplasmin-ferroxidase activity. CONCLUSION: In this study, ceruloplasmin-ferroxidase activity is higher in all groups in comparison to the healthy control. The significantly higher ceruloplasmin-ferroxidase activity was shown in bipolar disorder followed by the major depression and schizophrenia. The ceruloplasmin-ferroxidase activity was correlated with erythrocyte sedimentation rate in the bipolar disorder group and with C-reactive protein in the schizophrenia group. Therefore, the ceruloplasmin-ferroxidase activity may be an encouraging candidate in the neuro-immune modulation and become a reliable clinical tool for demonstrating the strong association of inflammation in these disorders.

show abstract

Comparative Study on Serum Levels of 10 Trace Elements in Schizophrenia

Cited by 35 publications

References 35 publications

Impaired fornix–hippocampus integrity is linked to peripheral glutathione peroxidase in early psychosis

Impaired fornix–hippocampus integrity is linked to peripheral glutathione peroxidase in early psychosis

A feasible strategy based on high ultrasound frequency and mass spectrometry for discriminating individuals diagnosed with bipolar disorder and schizophrenia through ionomic profile

Serum ceruloplasmin-ferroxidase activity in bipolar disorder is elevated compared to major depressive disorder and schizophrenia: a controlled study

Contact Info

Product

Resources

About