Comparing endometrial hysteroscopic and histological findings of infertile women with polycystic ovary syndrome and unexplained infertility: A cross-sectional study

Amooee, Sedigheh; Akbarzadeh‐Jahromi, Mojgan; Motavas, Maedeh; Zarei, Fariba

doi:10.18502/ijrm.v18i1.6195

Cited by 10 publications

(11 citation statements)

References 30 publications

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“…The pregnancy rate was low when the thickness of the endometrium was 14mm. Other research study results show that the individuals that achieved more than 7.5mm endometrium thickness have a better chance of pregnancy as compared to the individuals who have less than 7.5mm endometrial thickness 17,18 .…”

Section: Literature Reviewmentioning

confidence: 89%

Sonographic Correlation between Endometrial Thickness and Infertility - A systematic review

Siddique¹,

Murrium²,

Bacha³

et al. 2021

PJMHS

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Background: Infertility is defined as not conceiving after one year of unprotected sex. Apart from age, physical and hormonal misbalance, and lifestyle or environmental factors for infertility; Endometrial thickness has an important role in conception. Females with the 8-12mm endometrial thickness in the late proliferative phase had great chances to get conceive. Aim: To determine the sonographic diagnostic features of the endometriumthickness with Transvaginal high-resolution ultrasound are predictive of infertility. Methods: An electronic database search was performed (Google Scholar, Science Direct, and PubMed) with the data range from 1988 to 2020.All studies, fully-available in English, assessing the endometrial thickness in the gray-scale image on TAS/TVs. Results: Thirty-three articles were found, we evaluated the performance of ultrasound diagnostic techniques, for the measurement of endometrial thickness, our results showed that ultrasound had a high level of diagnostic capability for measuring endometrial thickness. If endometrial thickness is more than 14mm or less than 7mm then chances of pregnancy were zero, so high chances of pregnancy when the endometrial thickness is 8mm to 11mm. Conclusion: We concluded that when the endometrial thickness was increased from 8 mm to 11 mm the chances of pregnancy were maximum, and when the thickness of endometrium was more than 14 mm or, less than 7 mm the pregnancy ratio was almost zero. Transvaginal ultrasound is an excellent imaging modality and its sensitivity is high for the measurement of endometrial thickness Keyword: Transvaginal sonography, endometrial thickness, Infertility

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Section: Literature Reviewmentioning

confidence: 89%

Sonographic Correlation between Endometrial Thickness and Infertility - A systematic review

Siddique¹,

Murrium²,

Bacha³

et al. 2021

PJMHS

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“…A recent study found that some infertile women with PCOS, without endometrial thickening, had normal hysteroscopic findings associated with abnormal endometrial biopsies. This raises the possibility that hysteroscopic evaluation alone might not be sufficient to detect potential endometrial pathologies in women with infertility [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Hysteroscopy With Histopathological Findings of the Endometrium in Women With Polycystic Ovary Syndrome (PCOS)-Related Infertility

Rani,

Durga Mounika,

Singhal

2024

Cureus

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Introduction There have been numerous studies on the anovulatory factor, leading to infertility in women with polycystic ovary syndrome (PCOS); however, studies on the endometrium factor causing infertility in PCOS women are scarce. While hysteroscopy can accurately diagnose endometrial disorders such as endometrial polyps, it may be ineffective in detecting probable endometrial pathologies due to different hormonal habitats in these patients. Materials and methods Sixty patients with PCOS-related infertility were included in the study. All participants underwent hysteroscopic examination followed by endometrial biopsy and histopathological examination. The clinical and hormonal profiles of two main subgroups, that is, (a) normal endometrium (N), which included proliferative endometrium and secretory endometrium on histology, and (b) disordered endometrium (D), which included disordered endometrium on histology, were compared. Results There was no correlation between hysteroscopic and histopathological findings of PCOS infertile women. In the subgroup analysis of the two main histological types, that is, normal (proliferative and secretory) and disordered (disordered endometrium), age (28.70±4.66 vs. 32.9±5.61, p=0.012) and duration of amenorrhea (5.49±2.43 vs. 7.82±2.93, p=0.008) were significantly higher in the disordered group. There was a statistically nonsignificant higher BMI in the patients of the disordered endometrium group. Conclusion These findings suggest that endometrial biopsy and histopathological evaluation along with hysteroscopy should be desired in women with PCOS-related infertility, especially if they are in the late reproductive age group and have a longer duration of amenorrhea, regardless of endometrial thickening. This approach is essential to diagnose and treat endometrial disorder, which can be an additional cause of infertility, recurrent implantation failure, and recurrent pregnancy loss, in addition to ovulatory dysfunction.

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“…Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women (1). The causes of PCOS can be attributed to defects in the hypothalamic-pituitary function and insulin action (2).…”

Section: Introductionmentioning

confidence: 99%

The effect of hydroalcoholic extract of Nigella Sativa seed on dehydroepiandrosterone-induced polycystic ovarian syndrome in rats: An experimental study

Khani¹,

Abdollahi²,

Khalaj³

et al. 2021

IJRM

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Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women. Objective: The aim of this study was to investigate the therapeutic effect of hydroalcoholic extract of Nigella sativa (N. sativa) seed as a plant, the consumption of which has been recommended in Islam, on dehydroepiandrosterone (DHEA)-induced PCOS rats. Materials and Methods: This experimental study was carried out on 36 Wistar female rats (3 wk, 60 ± 10 gr). Then rats were divided into 6 groups (n = 6/each): control; PCOSinduced (DHEA 60 mg/kg/sc); PCOS + Metformine (30 mg/kg); and three experimental groups receiving DHEA + hydroalcoholic extract of N. sativa seeds in doses of 50, 100 and 200 mg/kg, respectively. Blood samples were taken for the evaluation of sexual hormones, oxidative stress, glucose, and insulin after 30 days of treatment. Ovarian tissue was used for histopathological study. Results: The serum levels of luteinizing hormone, testosterone, glucose, insulin resistance, malondialdehyde, and insulin (p ≤ 0.001) and estrogen increased while the levels of progesterone (p = 0.01) and antioxidant enzymes in the PCOS group decreased (p ≤ 0.001). Conclusion: The administration of the N. sativa extract to the PCOS rats resulted in remarkable changes in the serumic factors relative to the PCOS group. In addition, the extract improved the structure of the ovarian tissue in the PCOS rat. The histopathological results which are in accordance with biochemical findings imply that N. sativa seed could be useful in the treatment of PCOS, the higher doses of the extract being more effective. Key words: Nigella sativa seed, Oxidative stress, Insulin resistance, Polycystic ovary syndrome, Rat.

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Comparing endometrial hysteroscopic and histological findings of infertile women with polycystic ovary syndrome and unexplained infertility: A cross-sectional study

Cited by 10 publications

References 30 publications

Sonographic Correlation between Endometrial Thickness and Infertility - A systematic review

Sonographic Correlation between Endometrial Thickness and Infertility - A systematic review

Correlation of Hysteroscopy With Histopathological Findings of the Endometrium in Women With Polycystic Ovary Syndrome (PCOS)-Related Infertility

The effect of hydroalcoholic extract of Nigella Sativa seed on dehydroepiandrosterone-induced polycystic ovarian syndrome in rats: An experimental study

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