Comparing In Vitro Adsorption Studies With The Filmadsorber And Other Haemoperfusion Devices

Berlo, A. M. W. van; Poelmans, A. P.; Pols, E. P. van der; Aarts, P. J. M.; Verkooyen, A. H. M.

doi:10.1007/978-1-349-07283-5_21

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…The support used consists of a polyester mesh, Polymon PES 150/40 (Polymon, Switzerland), 2.46 mg/cm 2 , coated with aporous layer of cellulose nitrate, 1 mg/cm 2 , with a nitrogen content of 11%. Coating is done with a home-made device as described elsewhere (6).…”

Section: Materlals and Methoosmentioning

confidence: 99%

A First Screening for Hemocompatibility of a Universal Support for Selective and Specific Hemoperfusion

et al. 1989

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A modified filmadsorber is presented, intended to be used for selective and specific hemoperfusion. It consists of a spirally wound cellulose nitrate film, onto which--after chemical activation with sodium periodate--albumin is bound, stabilized, sterilized and activated with glutaraldehyde. Various bioactive ligands containing amino groups can be coupled to this support. A subsequent treatment with dimethylamino borane stabilizes the bonds between cellulose nitrate, albumin, glutaraldehyde and ligand. Columns in which a second layer of albumin is bound to the support as a model for a bioactive ligand were first screened for hemocompatibility using rabbits. Leukocyte, thrombocyte and hematocrit behaviour during hemoperfusion showed that hemocompatibility of the support was good.

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Section: Materlals and Methoosmentioning

confidence: 99%

A First Screening for Hemocompatibility of a Universal Support for Selective and Specific Hemoperfusion

et al. 1989

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Hemoperfusion

Winchester¹

1989

Replacement of Renal Function by Dialysis

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Kinetic Modeling of Powder Charcoal Haemoperfusion

et al. 1986

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The aim of this study was to achieve more understanding of the mass transfer characteristics of the filmadsorber haemoperfusion device. First, a structural model with mathematical description of the different diffusion steps was developed. Exact quantification appeared very difficult, resulting in insufficient fit of predicted and measured concentration curves. Moreover, the mathematics turned out simple, since the concentration courses could be described with one exponential power. Therefore, a formal model was developed, assuming linear isotherms and adsorption, proportional to the average concentration in the column. With this model predicted in-vitro inlet and outlet concentrations could be fitted to the measured data accurately. A relation between both models is given under the condition of high intraparticle mass transfer, which is allowed in case of powder adsorbents. It can be concluded that structural models do not yield predictive tools for optimization of device geometry. A formal model with two constants determining device performance enables device optimization with the help of some in-vitro experiments.

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Comparing In Vitro Adsorption Studies With The Filmadsorber And Other Haemoperfusion Devices

Cited by 3 publications

References 6 publications

A First Screening for Hemocompatibility of a Universal Support for Selective and Specific Hemoperfusion

A First Screening for Hemocompatibility of a Universal Support for Selective and Specific Hemoperfusion

Hemoperfusion

Kinetic Modeling of Powder Charcoal Haemoperfusion

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