Comparing indicators of health and development of singleton young adults conceived with and without assisted reproductive technology

Halliday, Jane; Wilson, Cate; Hammarberg, Karin; Doyle, Lex W.; Bruinsma, Fiona; McLachlan, Robert I; McBain, John; Berg, Turi; Fisher, Jane; Amor, David J.

doi:10.1016/j.fertnstert.2014.01.006

Cited by 47 publications

(37 citation statements)

References 45 publications

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“…The authors of the remaining ten studies were contacted by email with a request for the means and standard deviations for weight and/or height. The authors of two studies were able to supply the means and standard deviations . Furthermore, one of the remaining studies reported the growth outcomes in medians and ranges, and assuming the Gaussian distribution of these outcomes, the outcome measures were converted to means and standard deviations .…”

Section: Resultsmentioning

confidence: 99%

“…The authors of two studies were able to supply the means and standard deviations. 27,28 Furthermore, one of the remaining studies reported the growth outcomes in medians and ranges, and assuming the Gaussian distribution of these outcomes, the outcome measures were converted to means and standard deviations. 18 Thus, we were able to include 13 studies in the meta-analyses.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta‐analysis

Bay

Lyngsø

Hohwü

et al. 2018

BJOG

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta‐analysis

Bay

Lyngsø

Hohwü

et al. 2018

BJOG

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“…The association between fertility treatments and increased risk of several pediatric morbidities in the offspring has been previously reported . This association may involve several underlying pathophysiologic mechanisms.…”

Section: Discussionmentioning

confidence: 71%

“…Data on long‐term health consequences of the offspring are scarce. Fertility treatments have been suggested to be associated with an increased risk of pediatric respiratory, cardiovascular, neurological, endocrine, and metabolic morbidities and even neoplasms in the offspring …”

Section: Introductionmentioning

confidence: 99%

Fertility treatments and the risk of pediatric obstructive sleep apnea in the offspring—Results from a population‐based cohort study

Imterat

Wainstock

Landau

et al. 2019

Pediatric Pulmonology

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Objective While the impact of fertility treatments on the perinatal outcome is well established, the long‐term effects on offspring are yet to be determined. The current study aimed to investigate the risk of long‐term obstructive sleep apnea (OSA) among children born following in vitro fertilization (IVF) and ovulation induction (OI) as compared with spontaneously conceived pregnancies. Study design A retrospective population‐based cohort study was performed. Exposure was defined as delivery following pregnancies conceived by IVF or OI. Incidence of OSA related hospitalizations of the offspring, up to the age of 18 years, was evaluated. A Kaplan‐Meier survival curve and multivariable Cox regression models were used to assess the association. Results During the study period, 242 187 singleton deliveries met the inclusion criteria; 1.1% were conceived following IVF (n = 2603), and 0.7% following OI (n = 1721). Offspring hospitalization rates, involving OSA (n = 1607), were higher among children conceived following IVF and OI pregnancies as compared with the rate in children conceived spontaneously (1.4% vs 1.2% vs 0.7%, respectively; P < .001). The Kaplan‐Meier survival curve demonstrated a significantly higher cumulative incidence of OSA related hospitalizations following IVF and OI (log‐rank P < .001). Using multiple Cox regression models, controlled for gestational age, maternal age, maternal smoking, maternal obesity, birthweight, offspring gender and obesity, IVF as well as OI exhibited a significant and independent association with pediatric OSA in all models with adjusted hazard ratios of 2.25, (95% confidence interval [CI] = 1.6‐3.1) and 1.63 (95% CI = 1.1‐2.5), respectively. Conclusion Both IVF and OI treatments appear to be independently associated with OSA in the offspring.

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“…Specifically, given that the details of fertilization method and embryo growth are generally believed to have at least some long-term impacts on development (Doherty et al, 2000;Mann et al, 2004;Rinaudo and Schultz, 2004;Rinaudo and Wang, 2012;Rivera et al, 2008;Vrooman and Bartolomei, 2017), we set out to identify persistent transcriptional changes driven by the different methods of fertilization used in assisted reproductive technologies (ART). Although assisted reproduction is generally considered safe (Halliday et al, 2019), it is clear that children conceived using assisted reproduction suffer from modestly increased risks for a wide range of disorders (Halliday et al, 2014). For example, intracytoplasmic sperm injection (ICSI) is associated with increased risks for congenital abnormalities, imprinting disorders, chromosomal abnormalities, and more subtle risks ranging from delayed neurological development to altered metabolism (Esteves et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Flexibility and constraint in preimplantation gene regulation in mouse

Conine

Krykbaeva

Song

et al. 2020

Preprint

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Although many features of embryonic development exhibit remarkable stability in the face of environmental perturbations, it is also clear that some aspects of early embryogenesis can be modulated by non-genetic influences during and after fertilization. Among potential perturbations experienced during reproduction, understanding the consequences of differing ex vivo fertilization methods at a molecular level is imperative for comprehending both the basic biology of early development and the potential consequences of assisted reproduction. Here, we set out to explore stable and flexible aspects of preimplantation gene expression using single-embryo RNAsequencing of mouse embryos fertilized by natural mating, in vitro fertilization, or intracytoplasmic sperm injection, as well as oocytes parthenogenetically activated to develop (parthenotes). This dataset comprises a resource of over eight hundred individual embryos, which we use for three primary analyses. First, we characterize the effects of each fertilization method on early embryonic gene regulation, most notably finding decreased expression of trophectoderm markers at later stages of preimplantation development in ICSI embryos. Second, we find massive gene misregulation in parthenotes beyond the expected defects in imprinted gene expression, and show that many of these changes can be suppressed by sperm total RNA. Finally, we make use of the single-embryo resolution of our dataset to identify both stablyexpressed genes and highly-variable genes in the early mouse embryo. Together, our data provide a detailed survey of the molecular consequences of different fertilization methods, establish parthenotes as a "tabula rasa" for understanding the role for sperm RNAs in preimplantation gene regulation, and identify subtypes of preimplantation embryos based on their expression of epivariable gene modules.

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Comparing indicators of health and development of singleton young adults conceived with and without assisted reproductive technology

Cited by 47 publications

References 45 publications

Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta‐analysis

Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta‐analysis

Fertility treatments and the risk of pediatric obstructive sleep apnea in the offspring—Results from a population‐based cohort study

Flexibility and constraint in preimplantation gene regulation in mouse

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