Comparing the Effects of Chlorogenic Acid and Ilex paraguariensis Extracts on Different Markers of Brain Alterations in Rats Subjected to Chronic Restraint Stress

Lima, María Eduarda de; Colpo, Ana Zilda Ceolin; Maya-López, Marisol; Rangel-López, Edgar; Becerril-Chávez, Hugo; Galván‐Arzate, Sonia; Villeda‐Hernández, Juana; Sánchez-Chapul, Laura; Túnez, Isaac; Folmer, Vanderlei; Santamarı́a, Abel

doi:10.1007/s12640-018-9963-6

Cited by 14 publications

(3 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also prevented the decrease in superoxide dismutase (Sod) and catalase (Cat) activities after induced seizures in the brains of Wistar rats (9). In another study with oxidative stress by De Lima et al CGA was unable to prevent all the alterations induced by CIS, suggesting that the protective properties of IP are the result of the combined effects of all its antioxidant compounds, which includes caffeine (16). Bixby et al in 2005 found a potent, dose-dependent protective effect against oxidative stress and the highest inhibition of protein nitration in IP compared with wine and green tea (17).…”

Section: Discussionmentioning

confidence: 98%

A Case–Control Study of the Effects of Chimarrão (Ilex paraguariensis) and Coffee on Parkinson's Disease

et al. 2021

View full text Add to dashboard Cite

Introduction: Coffee has been inversely associated with Parkinson's disease (PD) in many studies, and caffeine is the leading candidate to mediate this effect. Mate (Ilex paraguariensis, IP), a caffeinated beverage rich in antioxidants consumed in South America, was also inversely associated with PD in one study from Argentina. Other varieties of IP infusion, such as chimarrão, were never studied in PD. Chimarrão is a common caffeinated beverage consumed in Brazil made with the leaves and stems of IP.Methods: A case–control study was conducted to evaluate the relationship between chimarrão ingestion and PD in southern Brazil. All subjects answered a questionnaire about the frequency of chimarrão and coffee intake. A multiple regression analysis adjusted for age and sex was performed to assess the association between PD and chimarrão consumption.Results: We included 200 PD patients and 200 healthy controls. High consumption of chimarrão was inversely associated with PD (OR = 0.44, 95% CI = 0.24–0.81, P = 0.008). High consumption of coffee was also inversely associated with PD, as expected. Chimarrão remained associated when adjusted for coffee consumption, smoking history, and age (OR 0.46, 95% CI = 0.25–0.86, P = 0.014). These two exposures showed an additive effect.Conclusion:Chimarrão consumption was inversely associated with PD, even after adjusting for coffee intake, suggesting a possible protective role. IP's effect can be mediated by caffeine and through its antioxidant components. Chimarrão has a lower concentration of caffeine compared with coffee and has numerous substances with antioxidative effects that may be important to PD protection. Further studies are needed to test this hypothesis.

show abstract

Section: Discussionmentioning

confidence: 98%

A Case–Control Study of the Effects of Chimarrão (Ilex paraguariensis) and Coffee on Parkinson's Disease

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The most reported phytocompounds include carnosic acid, rosmarinic acid, and chlorogenic acid [ 24 ]. The chlorogenic acid, identified in our study, has antioxidant, antibacterial, and antifungal (against Candida ) action [ 33 , 34 ], as it reduces cell viability, increases the potential for mitochondrial depolarization and production of reactive oxygen species, and causes DNA fragmentation in fluconazole-resistant Candida species [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Antifungal Action of Herbal Plants’ Glycolic Extracts against Candida Species

et al. 2023

View full text Add to dashboard Cite

Candida spp. cause fungal infection that affects patients’ oral health. This study aimed to evaluate the isolated and synergistic antifungal effect of Rosa centifolia L., Curcuma longa L., Rosmarinus officinalis L., and Punica granatum L. glycolic extracts against Candida albicans, Candida dubliniensis, Candida tropicalis, and Candida krusei planktonic and biofilm forms. The plant extracts were chemically characterized and the main compounds were quantified by high-performance liquid chromatography (HPLC-DAD) analysis. The minimum inhibitory and minimum fungicidal concentrations of the extracts were determined, and antibiofilm activity was evaluated by MTT assay. Data were analyzed by one-way ANOVA and Tukey’s tests, and by Kruskal–Wallis and Dunn’s tests, considering a significance level of 5%. The main compounds identified in each of the extracts were: p-coumaric acid (2153.22 μg/100 mL) in the rosemary extract, gallotannins (4318.31 μg/100 mL) in the pomegranate extract, quercetin derivatives (3316.50 μg/100 mL) in the extract of white roses, and curcumin (135.09 μg/100 mL) in the turmeric extract. The combination of R. centifolia and C. longa glycolic extracts was effective against C. albicans, C. dubliniensis, and C. tropicalis biofilms over different periods (p < 0.05). The combination of R. officinalis and P. granatum glycolic extracts was effective against C. albicans and C. krusei biofilms after 30 min, and against C. tropicalis after 24 h, with all combinations showing an average reduction of 50% in cell viability (p < 0.05). In conclusion, the combined plant extracts have antifungal and antibiofilm action against Candida spp. in different concentrations and times of action.

show abstract

“…tumor necrosis factor alpha (TNF-α), interleukin (IL)-1 beta and IL-6) and increases anti-inflammatory cytokines (e.g. IL-4 and IL-13) in brain tissue of rodents (de Lima et al, 2019;Lee et al, 2020;Metwally et al, 2020;Singh et al, 2018). Shen et al (2012) suggested that CGA regulates inflammation by modulating the…”

Section: Oxidative Stress and Inflammationmentioning

confidence: 99%

Neuroprotective effects of green coffee bean extract against Alzheimer’s and Parkinson’s disease: a mini review

Farias-Pereira¹,

Young²,

Park³

2020

Food Life

View full text Add to dashboard Cite

show abstract

Comparing the Effects of Chlorogenic Acid and Ilex paraguariensis Extracts on Different Markers of Brain Alterations in Rats Subjected to Chronic Restraint Stress

Cited by 14 publications

References 48 publications

A Case–Control Study of the Effects of Chimarrão (Ilex paraguariensis) and Coffee on Parkinson's Disease

A Case–Control Study of the Effects of Chimarrão (Ilex paraguariensis) and Coffee on Parkinson's Disease

Antifungal Action of Herbal Plants’ Glycolic Extracts against Candida Species

Neuroprotective effects of green coffee bean extract against Alzheimer’s and Parkinson’s disease: a mini review

Contact Info

Product

Resources

About