1998
DOI: 10.1016/s1383-5769(98)00031-2
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Comparison between aseric and seric culture-derived exoantigens of Babesia divergens in their ability to induce immunoprotection in gerbils

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Cited by 6 publications
(2 citation statements)
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“…A previous study on tick-borne haemoprotozoan parasites Babesia spp reported that animals vaccinated with a vaccine derived from in vitro culture using SFM were 100% protected against babesiosis, while a protection of 83% was recorded in the animals vaccinated with vaccine derived from medium containing 40% FBS ( 23 ). These results confirm the ability of a vaccine derived from the in vitro cultures with a serum-free medium to protect animals, but it does not show whether this protection is related to the elimination of serum protein and biological agents as was suggested by other studies ( 24 ). The use of serum-free media such as ISF-1 could therefore not only be useful for vaccine production but also for studying the interaction between the host immune system and the parasite without the influence of the bovine serum and possible immune effectors and modulators it may contain.…”
Section: Discussionsupporting
confidence: 69%
“…A previous study on tick-borne haemoprotozoan parasites Babesia spp reported that animals vaccinated with a vaccine derived from in vitro culture using SFM were 100% protected against babesiosis, while a protection of 83% was recorded in the animals vaccinated with vaccine derived from medium containing 40% FBS ( 23 ). These results confirm the ability of a vaccine derived from the in vitro cultures with a serum-free medium to protect animals, but it does not show whether this protection is related to the elimination of serum protein and biological agents as was suggested by other studies ( 24 ). The use of serum-free media such as ISF-1 could therefore not only be useful for vaccine production but also for studying the interaction between the host immune system and the parasite without the influence of the bovine serum and possible immune effectors and modulators it may contain.…”
Section: Discussionsupporting
confidence: 69%
“…The primary cultures from erythrocytes of experimentally infected animals demonstrated the parasite persistence at very low parasitaemia in the infected animals for at least 28 weeks. After experimental infection, gerbils develop an acute and fatal illness; they are commonly 432 A. Chauvin et al used as models for B. divergens babesiosis, notably to test the efficacy of vaccines [4,7]. After natural infection, cattle do not always develop acute babesiosis; furthermore, they stay chronically infected [8].…”
Section: Discussionmentioning
confidence: 99%