Comparison Between Copeptin and Vasopressin in a Population From the Community and in People With Chronic Kidney Disease

Roussel, Ronan; Fezeu, Léopold; Marre, Michel; Velho, Gilberto; Fumeron, Frédéric; Jungers, Paul; Lantieri, Olivier; Balkau, Beverley; Bouby, Nadine; Bankir, Lise; Bichet, Daniel G.

doi:10.1210/jc.2014-2295

Cited by 119 publications

(128 citation statements)

References 29 publications

Supporting

Mentioning

119

Contrasting

Order By: Relevance

“…UD (or specific gravity) may be evaluated in 7 colored grades with commercially available dipsticks (Labtix 8SG and Multistix 8SG AMES/Bayer Diagnostics) or evaluated by refractometry using a hand-held refractometer (Pen Urine S.G., Atago, Tokyo, Japan) [45]. In the DESIR study (a cohort of the French population), UD was measured with dipsticks in fresh spot morning urine samples from 1,604 subjects, and eU osm was calculated (same formula as here) [8]. Median (IQR) eU osm was 664 (272) mosm/L.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Validation of Surrogates of Urine Osmolality in Population Studies

et al. 2017

Self Cite

View full text Add to dashboard Cite

Background: The importance of vasopressin and/or urine concentration in various kidney, cardiovascular, and metabolic diseases has been emphasized recently. Due to technical constraints, urine osmolality (U_osm), a direct reflect of urinary concentrating activity, is rarely measured in epidemiologic studies. Methods: We analyzed 2 possible surrogates of U_osm in 4 large population-based cohorts (total n = 4,247) and in patients with chronic kidney disease (CKD, n = 146). An estimated U_osm (eU_osm) based on the concentrations of sodium, potassium, and urea, and a urine concentrating index (UCI) based on the ratio of creatinine concentrations in urine and plasma were compared to the measured U_osm (mU_osm). Results: eU_osm is an excellent surrogate of mU_osm, with a highly significant linear relationship and values within 5% of mU_osm (r = 0.99 or 0.98 in each population cohort). Bland-Altman plots show a good agreement between eU_osm and mU_osm with mean differences between the 2 variables within ±24 mmol/L. This was verified in men and women, in day and night urine samples, and in CKD patients. The relationship of UCI with mU_osm is also significant but is not linear and exhibits more dispersed values. Moreover, the latter index is no longer representative of mU_osm in patients with CKD as it declines much more quickly with declining glomerular filtration rate than mU_osm. Conclusion: The eU_osm is a valid marker of urine concentration in population-based and CKD cohorts. The UCI can provide an estimate of urine concentration when no other measurement is available, but should be used only in subjects with normal renal function.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The availability of non-peptide, orally active selective AVP receptor antagonists (vaptans) [5,6] and of a reliable ELISA for the measurement of copeptin, a validated surrogate of AVP [7,8], has opened the door for a number of studies addressing the AVP/thirst pathway and osmoregulation in general (see review in [9]).…”

Section: Introductionmentioning

confidence: 99%

Validation of Surrogates of Urine Osmolality in Population Studies

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…43 It is of interest that fructose, but not glucose, stimulates vasopressin release in humans. 44,45 We recently showed that orally administered fructose augments circulating vasopressin levels (as determined by measuring copeptin, a validated biomarker for vasopressin 46 ) and urinary concentration in dehydrated rats. 47 Fructose also stimulates urinary sodium reabsorption 48 and reduces urea excretion 49 similar to vasopressin.…”

Section: Vasopressin: the Survival Hormonementioning

confidence: 99%

Metabolic and Kidney Diseases in the Setting of Climate Change, Water Shortage, and Survival Factors

Johnson

Stenvinkel

Jensen

et al. 2016

JASN

Self Cite

View full text Add to dashboard Cite

Climate change (global warming) is leading to an increase in heat extremes and coupled with increasing water shortage, provides a perfect storm for a new era of environmental crises and potentially, new diseases. We use a comparative physiologic approach to show that one of the primary mechanisms by which animals protect themselves against water shortage is to increase fat mass as a means for providing metabolic water. Strong evidence suggests that certain hormones (vasopressin), foods (fructose), and metabolic products (uric acid) function as survival signals to help reduce water loss and store fat (which also provides a source of metabolic water). These mechanisms are intricately linked with each other and stimulated by dehydration and hyperosmolarity. Although these mechanisms were protective in the setting of low sugar and low salt intake in our past, today, the combination of diets high in fructose and salty foods, increasing temperatures, and decreasing available water places these survival signals in overdrive and may be accelerating the obesity and diabetes epidemics. The recent discovery of multiple epidemics of CKD occurring in agricultural workers in hot and humid environments may represent harbingers of the detrimental consequences of the combination of climate change and overactivation of survival pathways.

show abstract

“…An estimated urine osmolarity (eU osm ) was calculated by an equation based on the sum of the three major urinary solutes making up 90-95% of the urinary osmoles [13]. …”

Section: Methodsmentioning

confidence: 99%

Urine Osmolarity and Risk of Dialysis Initiation in a CKD Cohort

Bankir

Plischke²,

Bouby³

et al. 2015

Ann Nutr Metab

Self Cite

View full text Add to dashboard Cite

Background: Several experimental studies in rats and a few association studies in humans suggest that the antidiuretic action of vasopressin may accelerate the progression of chronic kidney disease. We undertook a retrospective analysis in a monocentric cohort of 273 patients with chronic kidney disease stages 1-4, focusing on a strong variable of interest, urinary osmolarity, and a strong endpoint, dialysis initiation. Data was analyzed in a multivariate proportional sub-distribution hazards model for competing risk data with appropriate co-variates. Main Results: Over a median follow-up period of 92 months, dialysis was initiated in 105 patients. After adjustments for baseline creatinine clearance, and other confounding factors, a higher risk for initiation of dialysis was found in patients with higher urinary osmolarity. After 72 months, the estimated adjusted cumulative incidence probability for dialysis initiation was 15, 24, and 34% in patients with baseline urinary osmolarity of 315, 510, and 775 mosm/l, respectively (p = 0.033). Key Messages: In this retrospective, longitudinal study, a higher baseline urinary osmolarity was strongly associated with a higher risk of end-stage renal disease (after appropriate adjustments). Further, prospective studies are required to evaluate the possible benefit of interventions aiming at reducing urinary osmolarity as a potential treatment for slowing chronic kidney disease progression.

show abstract

Comparison Between Copeptin and Vasopressin in a Population From the Community and in People With Chronic Kidney Disease

Abstract: This study in a normal population, the largest ever with measurements of both peptides, shows that copeptin and vasopressin concentrations correlated well. But their relationship is distorted in CKD, suggesting that the peptide clearances differ when the renal function is impaired.

Cited by 119 publications

References 29 publications

Validation of Surrogates of Urine Osmolality in Population Studies

Validation of Surrogates of Urine Osmolality in Population Studies

Metabolic and Kidney Diseases in the Setting of Climate Change, Water Shortage, and Survival Factors

Urine Osmolarity and Risk of Dialysis Initiation in a CKD Cohort

Contact Info

Product

Resources

About