Comparison between the protective effects of vitamin K and vitamin A on the modulation of hypervitaminosis D3 short-term toxicity in adult albino rats

Elshama, Said Said; Osman, Hosam-Eldin Hussein; El-Kenawy, Ayman El-Meghawry; Youseef, Hamdi Mohamed

doi:10.3906/sag-1411-6

Cited by 6 publications

(8 citation statements)

References 22 publications

(28 reference statements)

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“…The results also agree with Elshama et al (2016), they showed a signi icant increase in serum urea associated with a substantial decrease in serum creatinine that received vitamin D 3 in a toxic dose (2 mg/kg), in comparison with the control group. As well, they indicated that differences between the toxic dose of vitamin D 3 and the renal function tests of urea and creatinine in rats.…”

Section: Results Ofsupporting

confidence: 90%

“…More intake of vitamin D supplements by the general population and a growing number of prescriptions of therapeutic doses (included very high doses) without medical monitoring might result in a greater risk of exogenous hypervitaminosis D, with symptoms of hypercalcemia also known as vitamin D toxicity (Marcinowska-Suchowierska et al, 2018). Physicians also recommend a high daily dose of vitamin D 3 for many weeks as a treatment for chronic bone diseases (osteomalacia and osteoporosis) and autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis because they are associated with low blood levels of vitamin D 3 metabolites; therefore, the incidence rate of hypervitaminosis D 3 may increase (Elshama et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Hypervitaminosis D3 on Liver, Kidney Functions in White Rats

Al-Hayali

2020

ijrps

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The research was undertaken to evaluate the effects of vitamin D3 on the liver and kidney functions through some haematological and biochemical parameters. The results illustrate that high doses (30000 and 50000 IU) of vitamin D3 significantly reduce the rats' body weights in about 46% additionally much of symptoms like weakness, the rigidity of limbs, neurological irritation, difficulty in movement, respiration and deaths occurrence. The results also showed that the high doses vitamin D3 has a significant decreased in Red Blood Corpuscles (RBCs), Hemoglobin (Hb), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), White Blood Corpuscles (WBCs), Lymphocytes (Lymph), Monocytes (Mono), Granulocytes (GRA) and Platelets (PLT) compared with the control group. In contrast, the Mean Corpuscular Hemoglobin Concentration (MCHC) and Platelet Distribution Width (PDW) significantly increased after 20-30 days of treatment . Besides, the results demonstrated a significant decrease in Alanine aminotransferase (ALT), Total Protein (TP), Creatinine (Cr) and increase in aspartate aminotransferase (AST), Blood Urea Nitrogen (BUN), Urea. While albumin did not give any significant differences. As well the study proved significantly increase in serum vitamin D3 concentration compared with the control group after 20-30 days of treatment. Since vitamin D3 can be beneficial for the organisms, but the overdoses of the vitamin can alter some parameters in the body.

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Section: Results Ofsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Effect of Hypervitaminosis D3 on Liver, Kidney Functions in White Rats

Al-Hayali

2020

ijrps

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“…Vitamin A is necessary for vitamin D signalling but excessive intakes, common in developed countries, can antagonise vitamin D’s effects, perhaps through annexation of the retinoid X receptor (RXR) to form RXR:RAR complexes ( 75 ). Experimentally, vitamin D toxicity is mitigated by large doses of vitamin A and in humans supplemental vitamin A can abolish health benefits of vitamin D supplementation ( 76 , 77 ). Other interactions are reported for vitamin K (and possibly other vitamins) ( 78 ).…”

Section: Other Dietary Factors Modulating Vitamin D Efficacymentioning

confidence: 99%

Why do so many trials of vitamin D supplementation fail?

Boucher

2020

Endocrine Connections

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Abstract. Our knowledge of vitamin D has come a long way since the 100 years it took for doctors to accept, between 1860-1890, that both sunlight and cod liver oil [a well-known folk remedy] cured and prevented rickets.1]Vitamins D2/3 were discovered exactly a hundred years ago and over the last 50 years vitamin D has been found to have many effects on virtually all human tissues and not just on bone health, while mechanisms effecting the actions of vitamin D at the cellular level are increasingly understood, but deficiency persists globally.2 Observational studies in humans have shown that better provision of vitamin D is strongly associated, dose-wise, with reductions in current and future health risks in line with the known actions of vitamin D. Randomised controlled trials, commonly accepted as providing a ‘gold standard’ for assessing the efficacy of new forms of treatment, have frequently failed to provide supportive evidence for the expected health benefits of supplementation. Such RCTs, however, have used designs evolved for testing drugs while vitamin D is a nutrient; the appreciation of this difference is critical to identifying health benefits from existing RCT data and for improving future RCT design. This report aims, therefore, to provide a brief overview of the evidence for a range of non-bony health benefits of vitamin D repletion; to discuss specific aspects of vitamin D biology that can confound RCT design and how to allow for them

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“…Fetuses’ renal atrophy and degeneration of Malpighian corpuscles were also noted by Andrew ( 2007 ), Tawfik and Al-Badr ( 2012 ), Osman et al ( 2012 ), Elshama et al ( 2016 ), and AL-Khatawi et al ( 2019 ). Park et al ( 2000 ) and Beyreuther et al ( 2007 ) suggested that prenatal exposure to MSG would result in histological changes in the kidney because MSG readily crossed the placenta and accumulated in fetal tissue throughout gestation.…”

Section: Discussionmentioning

confidence: 61%

Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats

Shosha

Ebaid

Toraih

et al. 2023

Environ Sci Pollut Res

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Monosodium glutamate (MSG) is a widespread flavor enhancer and stabilizer in manufactured or packaged foods that possess myriad adverse effects. This study aimed to evaluate the effect of MSG on placental progesterone receptors and fetal development. Thirty pregnant Wistar Albino rats were divided into three groups (ten/each). The control group (G1) gavaged distilled water only, low-dose treated group (G2) gavaged 3 g/kg MSG, and high-dose treated group (G3) gavaged 6 g/kg MSG from 1st to 18th days of gestation, and all pregnant rats were sacrificed on the 19th day of gestation. The effect of MSG on fetal weights, crown vertebral length (CVL), placental weight, placental ghrelin expression, and fetal skeleton examination were estimated. MSG induced a significant decrease in fetal weights, CVL lengths, placental weight, and ghrelin expression in both treatment groups compared to the control group. Several parts of the fetal skeleton showed incomplete ossification and delayed chondrification in which high-dose maternally treated fetuses were more affected. Many degenerative changes were detected in both maternal and fetal liver and kidney tissues in MSG-treated groups. Moreover, MSG caused a significant increase in serum ALT, ALP, and creatinine levels in pregnant rats’ blood. Serum progesterone was only elevated in G3 on the 19th day of gestation. This study showed that the administration of MSG during pregnancy adversely influences fetal growth and skeletal development and caused several biochemical and histological changes in the maternal and fetal liver and kidney tissues which assure the toxic and teratogenic effects of MSG.

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Comparison between the protective effects of vitamin K and vitamin A on the modulation of hypervitaminosis D3 short-term toxicity in adult albino rats

Cited by 6 publications

References 22 publications

Effect of Hypervitaminosis D3 on Liver, Kidney Functions in White Rats

Effect of Hypervitaminosis D3 on Liver, Kidney Functions in White Rats

Why do so many trials of vitamin D supplementation fail?

Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats

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