Comparison of a new PillCam&amp;trade; SB2 video capsule versus the standard PillCam&amp;trade; SB for detection of small bowel disease

Metzger, Yoav C.; Adler, Samuel N.; Shitrit, Ariella Bar-Gil; Koslowsky, Binyamin; Bjarnason, Ingvar

doi:10.2147/rmi.s4227

Cited by 35 publications

(25 citation statements)

References 5 publications

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“…In our Institution, PillCam SB1 system was used on 5 cases, whereas the remaining 19 subjects underwent videocapsule endoscopy by means of the PillCam SB2 system. Despite the PillCam SB2 providing superior image quality to the PillCam SB1, several studies demonstrated that the PillCam SB2 did not produce a statistically greater diagnostic yield [11,12]. For this reason both groups were included in the design of the study.…”

Section: Discussionmentioning

confidence: 99%

The Role of Wireless Capsule Endoscopy (WCE) in the Detection of Occult Primary Neuroendocrine Tumors

Furnari

Buda²,

Delconte

et al. 2017

JGLD

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Background & Aims: Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms with unclear etiology that may show functioning or non-functioning features. Primary tumor localization often requires integrated imaging. The European Neuroendocrine Tumors Society (ENETS) guidelines proposed wireless-capsule endoscopy (WCE) as a possible diagnostic tool for NETs, if intestinal origin is suspected. However, its impact on therapeutic management is debated. We aimed to evaluate the yield of WCE in detecting intestinal primary tumor in patients showing liver NET metastases when first-line investigations are inconclusive.Method: Twenty-four patients with histological diagnosis of metastatic NET from liver biopsy and no evidence of primary lesions at first-line investigations were prospectively studied in an ENETS-certified tertiary care center. Wireless-capsule endoscopy was requested before explorative laparotomy and intra-operative ultrasound. The diagnostic yield of WCE was compared to the surgical exploration.Results: Sixteen subjects underwent surgery; 11/16 had positive WCE identifying 16 bulging lesions. Mini-laparotomy found 13 NETs in 11/16 patients (9 small bowel, 3 pancreas, 1 bile ducts). Agreement between WCE and laparotomy was recorded in 9 patients (Sensitivity=75%; Specificity=37.5%; PPV=55%; NPV=60%). Correspondence assessed per-lesions produced similar results (Sensitivity=70%; Specificity=25%; PPV=44%; NPV=50%). No capsule retentions were recorded.Conclusions: Wireless-capsule endoscopy is not indicated as second-line investigation for patients with gastro-entero-pancreatic NETs. In the setting of a referral center, it might provide additional information when conventional investigations are inconclusive about the primary site.Abbreviations: DBE: double balloon enteroscopy; GEP-NET: gastro-entero-pancreatic neuroendocrine tumor; GI: gastrointestinal; ENETS: European Neuroendocrine Tumor Society; NET: neuroendocrine tumor; SSRS: somatostatin receptor scintigraphy; WCE: wireless capsule endoscopy.

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Section: Discussionmentioning

confidence: 99%

The Role of Wireless Capsule Endoscopy (WCE) in the Detection of Occult Primary Neuroendocrine Tumors

Furnari

Buda²,

Delconte

et al. 2017

JGLD

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“…2 The MAC with standard biopsy forceps The frontal unit is 11 mm in diameter, 26 mm in length, and 10.5 g in mass. Its shape, size, and volume are comparable to a wireless capsule endoscope [27]. The multilumen tether has three channels, i.e., the two PTFE sheaths described above and a third lumen allowing electrical connection to the vision module and the magnetic field sensor.…”

Section: Platform Descriptionmentioning

confidence: 99%

Magnetic air capsule robotic system: proof of concept of a novel approach for painless colonoscopy

et al. 2011

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Background Despite being considered the most effective method for colorectal cancer diagnosis, colonoscopy take-up as a mass-screening procedure is limited mainly due to invasiveness, patient discomfort, fear of pain, and the need for sedation. In an effort to mitigate some of the disadvantages associated with colonoscopy, this work provides a preliminary assessment of a novel endoscopic device consisting in a softly tethered capsule for painless colonoscopy under robotic magnetic steering. Methods The proposed platform consists of the endoscopic device, a robotic unit, and a control box. In contrast to the traditional insertion method (i.e., pushing from behind), a "front-wheel" propulsion approach is proposed. A compliant tether connecting the device to an external box is used to provide insufflation, passing a flexible operative tool, enabling lens cleaning, and operating the vision module. To assess the diagnostic and treatment ability of the platform, 12 users were asked to find and remove artificially implanted beads as polyp surrogates in an ex vivo model. In vivo testing consisted of a qualitative study of the platform in pigs, focusing on active locomotion, diagnostic and therapeutic capabilities, safety, and usability. Results The mean percentage of beads identified by each user during ex vivo trials was 85 ± 11%. All the identified beads were removed successfully using the polypectomy loop. The mean completion time for accomplishing the entire procedure was 678 ± 179 s. No immediate mucosal damage, acute complications such as perforation, or delayed adverse consequences were observed following application of the proposed method in vivo. Conclusions Use of the proposed platform in ex vivo and preliminary animal studies indicates that it is safe and operates effectively in a manner similar to a standard colonoscope. These studies served to demonstrate the platform's added advantages of reduced size, front-wheel drive strategy, and robotic control over locomotion and orientation.

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“…While similar in diagnostic yield, a study revealed improvements in homogenous light exposure, sharpness, resolution, depth of view and overall impression when comparing the PillCam SB2 to the original PillCam [4].…”

Section: Historymentioning

confidence: 95%

Video Capsule Endoscopy: The Past, Present, and Future

Whitmer¹

2013

J Gastrointest Dig Syst

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Comparison of a new PillCam™ SB2 video capsule versus the standard PillCam™ SB for detection of small bowel disease

Cited by 35 publications

References 5 publications

The Role of Wireless Capsule Endoscopy (WCE) in the Detection of Occult Primary Neuroendocrine Tumors

The Role of Wireless Capsule Endoscopy (WCE) in the Detection of Occult Primary Neuroendocrine Tumors

Magnetic air capsule robotic system: proof of concept of a novel approach for painless colonoscopy

Video Capsule Endoscopy: The Past, Present, and Future

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