The new second-generation colon capsule endoscopy is a safe and effective method for visualizing the colon and detecting colonic lesions. Sensitivity and specificity for detecting colorectal polyps appear to be very good, suggesting a potential for improved accuracy compared with the first-generation system. Further prospective and comparative studies are needed.

The PillCam ESO 2 demonstrated excellent visualization of the Z line. Compared with standard EGD, the PillCam ESO 2 had good test characteristics with high rates of detection of suspected Barrett's esophagus and esophagitis. This study provides indirect validation of the simplified ingestion procedure. The PillCam ESO 2 acquires high quality esophageal images, performs safely, and should be able to replace the current PillCam ESO.

Background: Capsule endoscopy is the procedure of choice for many suspected small bowel diseases. PillCam™ small bowel (SB), has a high diagnostic yield. No improvements have been made on its optics since its introduction in 2002. Aim: To compare the diagnostic yield and quality of visualization of PillCam™ SB with that of a new small bowel endoscope (PillCam™ SB2) which has a larger angle of view and upgraded visual attributes. Methods: Twenty patients were randomized to undergo capsule enteroscopy with PillCam™ SB and PillCam™ SB2 a week apart. Results: Both procedures had a comparable diagnostic yield. However images from PillCam™ SB2 were found to be signifi cantly better in regards of homogenous light exposure (P Ͻ 0.001), sharpness and resolution (P Ͻ 0.001), depth of view (P Ͻ 0.005), and overall impression (P Ͻ 0.0001). Conclusion: PillCam™ SB2 appears to be superior to the original PillCam™ SB in regard to quality of images obtained.

Capsule endoscopy for the colon was introduced to allow an alternative screening method to the invasive classic colonoscopy. The results of initial studies have shown inferior detection rates of colonic polyps by the colon capsule. In this paper we aim to review and summarize the recent advances in wireless capsule endoscopy of the colon. Publications regarding the use of colon capsule with new technology, as well as personal experience, were reviewed. Since the introduction of the first generation of the colon capsule, many improvements have been made to create a better capsule endoscope. These include a wider angle of view, a faster adaptable frame rate and a new data recorder which is able to control the capsule activity during the transit through the bowel. Recent studies show these improvements had a direct effect on the colon capsule performance, leading to a better diagnostic yield. Recent advancements in the technology of the wireless colon capsule endoscope offer the option to screen patients for colonic polyps noninvasively. Colon capsule endoscopy may become relevant for assessment of extent of inflammatory bowel disease.

BGE is safe. BGE enables deep intubation of the small bowel beyond the ligament of Treitz utilizing standard endoscopes. Insertion depth with this technique is beyond that achieved by push enteroscopy. Further studies are needed, and technical improvements will lead to deeper insertion.