Comparison of Amoxicillin–Metronidazole Plus Famotidine or Lansoprazole for Amoxicillin–Clarithromycin–Proton Pump Inhibitor Treatment Failures for <i>Helicobacter pylori</i> Infection

Murakami, Kazunari; Kodama, Masaaki; Sato, Ryugo; Miyajima, Hajime; Ono, Masami; Inoue, Katsumi; Watanabe, Koichiro; Otsu, Satoshi; Fujioka, Toshio

doi:10.1111/j.1523-5378.2006.00435.x

Cited by 19 publications

(21 citation statements)

References 24 publications

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“…Adicionalmente, en este país se compararon las tasas de erradicación de la triple terapia estándar con metronidazol frente a la triple terapia con famotidina, y la terapia cuádruple con bismuto o concomitante por 7 días de duración, obteniendo la triple terapia estándar con metronidazol tasas de erradicación por ITT del 97% versus la triple terapia con famotidina del 94%, y en análisis por ITT/PP para la terapia triple estándar con metronidazol del 88.5-93.9%, versus la terapia cuádruple sin bismuto o concomitante del 82.7-84.3% 34,35 . En España, la terapia cuádruple con bismuto versus la triple terapia con rifabutina de 7 días de duración logró porcentajes de erradicación por ITT para cada terapia del 70.4 y del 44.4% 36 .…”

Section: Ensayos Clínicos Aleatorizadosunclassified

Tratamiento ideal del Helicobacter pylori: una revisión sistemática

Sierra

Forero

Rey

2014

Revista de Gastroenterología de México

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Section: Ensayos Clínicos Aleatorizadosunclassified

Tratamiento ideal del Helicobacter pylori: una revisión sistemática

Sierra

Forero

Rey

2014

Revista de Gastroenterología de México

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“…After failure of a combination of PPI, amoxicillin and clarithromycin, a theoretically correct alternative would be the use, as second option, of other PPI-based triple therapy including amoxicillin (that does not induce resistance) and metronidazole (an antibiotic not used in the first trial), and several authors have reported encouraging results with this strategy [Ueki et al 2009;Murakami et al 2008Murakami et al , 2006Shirai et al 2007;Matsuhisa et al 2006;Nagahara et al 2004;Shimoyama et al 2004;Isomoto et al 2003;Miwa et al 2003]. However, in our experience, when this therapy has been administered twicedaily for 1 week, eradication rates lower than 50% have been obtained [Gisbert et al 1999a]; the subsequently use of higher (three times per day) antibiotic doses, was followed only by a mild increase in eradication rate (58%), which was still unacceptable [Gisbert et al 1999a].…”

Section: Introductionmentioning

confidence: 99%

Review: Second-line rescue therapy of Helicobacter pylori infection

Gisbert

2009

Therap Adv Gastroenterol

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Helicobacter pylori infection is the main known cause of gastritis, gastroduodenal ulcer disease and gastric cancer. After more than 20 years of experience in H. pylori treatment, however, the ideal regimen to treat this infection has still to be found. Nowadays, apart from having to know well first-line eradication regimens, we must also be prepared to face treatment failures. Therefore, in designing a treatment strategy we should not focus on the results of primary therapy alone, but also on the final (overall) eradication rate. The choice of a 'rescue' treatment depends on which treatment is used initially. If a first-line clarithromycin-based regimen was used, a second-line metronidazole-based treatment (quadruple therapy) may be used afterwards, and then a levofloxacin-based combination would be a third-line 'rescue' option. Alternatively, it has recently been suggested that levofloxacin-based 'rescue' therapy constitutes an encouraging second-line strategy, representing an alternative to quadruple therapy in patients with previous PPI-clarithromycin-amoxicillin failure, with the advantage of efficacy, simplicity and safety. In this case, quadruple regimen may be reserved as a third-line 'rescue' option. Finally, rifabutin-based 'rescue' therapy constitutes an encouraging empirical fourth-line strategy after multiple previous eradication failures with key antibiotics such as amoxicillin, clarithromycin, metronidazole, tetracycline, and levofloxacin. Even after two consecutive failures, several studies have demonstrated that H. pylori eradication can finally be achieved in almost all patients if several 'rescue' therapies are consecutively given. Therefore, the attitude in H. pylori eradication therapy failure, even after two or more unsuccessful attempts, should be to fight and not to surrender.

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“…The antibiotic resistance of H. pylori is considered to be a signifi cant factor in determining the success of eradication. 16,22 In particular, recent evidence has stressed the major infl uence of clarithromycin resistance on the outcome of therapy including clarithromycin. The cure rate may drop as much as 55% because of the presence of clarithromycin-resistant H. pylori strains.…”

Section: Discussionmentioning

confidence: 99%