Comparison of Analgetic Activity of 67 Arylalkamines with That of Morphine and Meperidine by the Mouse Hot Plate Method*†

Slow‐sustained delivery of naloxone reduces typical naloxone‐induced precipitated opioid withdrawal effects in male morphine‐dependent mice

“…Lastly, in the open field test there were no significant differences between saline and Nal-cNP treatment groups in locomotor activity and production To ensure acute MOR antagonism of Nal-cNPs, we first sought to study the impact of Nal-cNPs on morphine-induced thermal antinociception compared to free naloxone. The hotplate test has been used for decades to assess acute thermal nociception (Fennessy & Lee, 1970;Holck, Kimura, & Kimura, 1950;Pleuvry & Tobias, 1971).…”

1,2-Diphenyl-2-Aminoethanols. I. Synthesis of some erythro-1,2-Diphenyl-2-Alkylaminoethanols

“…The recent elucidation of the exact structure of these two racemic pairs (4) has now allowed correlation of structure with pharmacological activity. The erythro racemate is inactive as an analgesic, the threo racemate weakly active in mice (3). It is peculiar that although the threo racemate is reported to have some analgesic activity, the individual threo enantiomorphs are stated to be inactive.…”

“…•' Product isolated as free base. 3 The absorption of hydrogen exceeded theory; it is probable that some debenzylation occurred. h Lit.…”

“…Regeneration of Zevo-Vb by shaking a portion of the penicillin salt with dilute alkali and ether, separating the ether layer and evaporating the solvent yielded the levorotatory enantiomorph of Vb, [ ] 5 -34.4°. 3 The ether filtrate containing dextro-Yb was treated with an ether solution of benzylpenicillinic acid prepared from 7.4 g. (0.02 mole) of potassium benzylpenicillinate in a manner similar to that described above. A gum separated at first, which slowly solidified on rubbing with a stirring rod.…”