Comparison of anti 60 and 52 kDa SS-A/Ro antibodies in the pathogenesis of cutaneous lupus erythematosus

Yoshimasu, Takashi; Hiroi, Akihisa; Ohtani, Toshio; Uede, Koji; Furukawa, Fukumi

doi:10.1016/s0923-1811(02)00004-x

Cited by 15 publications

(10 citation statements)

References 17 publications

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“…Moreover, in vitro experiments involving UVB-irradiated keratinocytes isolated from SLE or subacute cutaneous lupus skin showed increased binding of anti-Ro IgG antibodies, resulting in enhanced ADCC. In contrast, irradiated keratinocytes from DLE patients did not show enhanced ADCC [30, 31]. Despite these negative findings in DLE lesional skin, our data showing B cells congregating in different areas of DLE lesional skin supports the notion of B cells and potentially autoantibodies being involved in the pathology of DLE.…”

Section: Discussionmentioning

confidence: 45%

Site-Specific Analysis of Inflammatory Markers in Discoid Lupus Erythematosus Skin

Thorpe

Gray

Kumar

et al. 2014

The Scientific World Journal

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Prior studies identified T cells, B cells, and macrophages in the inflammatory infiltrate and up-regulation of their protein products in discoid lupus erythematosus (DLE) skin; however, they lacked rigorous analyses to define their specific locations in skin. Thus, we compared expressions of selected T cell, B cell, and macrophage markers in five areas of DLE, psoriasis, and normal skin. Immunostainings for CD3, CD4, CD8, CD20, CD68, CXCR3, CXCL10, and TIA-1 were performed in biopsies of 23 DLE lesional skin, 11 psoriasis lesional skin, and 5 normal skin. Three independent observers used a graded scale to rate each marker's presence in the epidermis, dermatoepidermal junction (DEJ), perivascular area, periadnexal area, and deep dermis. DLE lesional skin contained an increased abundance of CD3+, CD8+, and CD68+ cells at the DEJ, and CD20+ and CD68+ cells in the periadnexal area versus psoriasis and normal skin. CXCR3, CXCL10, and TIA-1 were elevated in periadnexal sites of DLE lesional skin versus psoriasis lesional skin. The aggregation of T cells, B cells, macrophages, and their protein products (CXCR3, CXCL10, and TIA-1) in the DEJ and periadnexal area of DLE lesional skin may contribute to the pathology of DLE through a coordinated, sophisticated process.

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Section: Discussionmentioning

confidence: 45%

Site-Specific Analysis of Inflammatory Markers in Discoid Lupus Erythematosus Skin

Thorpe

Gray

Kumar

et al. 2014

The Scientific World Journal

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“…SS is an autoimmune disease where autoantibodies, such as SS-A/Ro and SS-B/La antibodies, are detected very frequently [1] . The anti-SS-A antibody has been attracting attention because it is detected not only in cases of SS but also in subacute dermal lupus, in which a specific skin eruption is caused by ultraviolet rays, annular erythema and neonatal lupus associated with a complete atrioventricular block [51] . The antigen corresponding to the anti-SS-A antibody is expressed when keratinocytes are exposed to ultraviolet rays and its induction is blocked by N-acetylcysteine, a reductant in oxidative stress [52] .…”

Section: Discussionmentioning

confidence: 99%

Possible Involvement of Oxidative Stress in Salivary Gland of Patients with Sjögren’s Syndrome

Ryo¹,

Yamada²,

Nakagawa

et al. 2006

Pathobiology

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Objective: To determine the involvement of oxidative stress in the salivary gland of patients with Sjögren’s syndrome (SS). Methods: Oxidative damage to the gland was measured by 8-hydroxy-2′-deoxyguanosine (8-OHdG) and hexanoyl-lysine (HEL) using the SS saliva. In addition, lactate dehydrogenase (LDH) and mitochondrial glutamic-oxaloacetic transaminase (m-GOT), both general markers for cell damage, were also analyzed. Results: Increased levels of 8-OHdG and HEL were found in the saliva of SS patients, but not in that of patients with other salivary gland dysfunction or of healthy individuals. Levels of LDH and m-GOT were significantly correlated with 8-OHdG and HEL levels, respectively. Furthermore, the increased levels of 8-OHdG and HEL were also correlated in the SS saliva. Conclusion: These findings suggested the involvement of oxidative stress in glandular tissue destruction in SS. It was indicated that the detection of 8-OHdG and HEL in the saliva may become a useful tool for the diagnosis of SS.

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“…Anti-Ro/SS-A está presente em até 7,1% dos casos de LECD (19) , sendo um dos mais importantes autoanticorpos, junto com AAN, na avaliação de pacientes com hipótese diagnóstica de LES (1,21,22) . Anti-Ro/SS-A de 60 e 52 kDa parecem ter pequena contribuição na patogênese da lesão discóide, ao contrário do demonstrado no lúpus neonatal (23) . Em nossa casuística, anti-Ro/SS-A ocorreu em 12,5% dos pacientes com LECD e 35,2% dos casos de LES.…”

Section: Discussionunclassified

Marcadores de envolvimento sistêmico no lúpus eritematoso crônico discóide

Marçon¹,

Moraes²,

Lanzelotti³

et al. 2004

Rev. Bras. Reumatol.

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Comparison of anti 60 and 52 kDa SS-A/Ro antibodies in the pathogenesis of cutaneous lupus erythematosus

Cited by 15 publications

References 17 publications

Site-Specific Analysis of Inflammatory Markers in Discoid Lupus Erythematosus Skin

Site-Specific Analysis of Inflammatory Markers in Discoid Lupus Erythematosus Skin

Possible Involvement of Oxidative Stress in Salivary Gland of Patients with Sjögren’s Syndrome

Marcadores de envolvimento sistêmico no lúpus eritematoso crônico discóide

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