Comparison of Candida species isolated from children with and without early childhood caries: A descriptive cross-sectional study

Beena,; Peedikayil, Faizal C; GufranAfmed, MB; Chandru, TP; Soni, Kamlesh A.; Dhanesh, N.

doi:10.4103/jisppd.jisppd_160_17

Cited by 11 publications

(12 citation statements)

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“…Streptococcus mutans thrives in a cariogenic biofilm with multiple species of bacteria and fungi. The commensal fungus Candida albicans is frequently detected in high numbers with S. mutans recovered from children with ECC, but only sporadically from children without ECC . Candida albicans is a common colonizer of the oral cavity and an opportunistic pathogen.…”

Section: Introductionmentioning

confidence: 99%

Antigen I/II mediates interactions between Streptococcus mutans and Candida albicans

Yang

Scoffield

et al. 2018

Molecular Oral Microbiology

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Streptococcus mutans and Candida albicans are frequently co-isolated from dental plaque of children with early childhood caries (ECC) and are only rarely found in children without ECC, suggesting that these species interact in a manner that contributes to the pathogenesis of ECC. Previous studies have demonstrated that glucans produced by S. mutans are crucial for promoting the formation of biofilm and cariogenicity with C. albicans; however, it is unclear how non-glucan S. mutans biofilm factors contribute to increased biofilm formation in the presence of C. albicans. In this study we examined the role of S. mutans antigen I/II in two-species biofilms with C. albicans, and determined that antigen I/II is important for the incorporation of C. albicans into the two-species biofilm and is also required for increased acid production. The interaction is independent of the proteins Als1 and Als3, which are known streptococcal receptors of C. albicans. Moreover, antigen I/II is required for the colonization of both S. mutans and C. albicans during co-infection of Drosophila melanogaster in vivo. Taken together, these results demonstrate that antigen I/II mediates the increase of C. albicans numbers and acid production in the two-species biofilm, representing new activities associated with this known S. mutans adhesin.

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Section: Introductionmentioning

confidence: 99%

Antigen I/II mediates interactions between Streptococcus mutans and Candida albicans

Yang

Scoffield

et al. 2018

Molecular Oral Microbiology

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“…Dental caries is a complex disease that has multiple contributing factors [1]. One destructive form of tooth decay that commonly affects young children is early childhood caries (ECC) [2]. ECC is defined as the presence of one or more decayed teeth, missing (due to caries) or filled teeth surface in a child 71 months of age or younger [3,4].…”

Section: Introductionmentioning

confidence: 99%

Antifungal effectiveness of virgin coconut oil mousse against Candida albicans biofilm in children with early childhood caries

Monica

Fauziah²,

Budiardjo³

et al. 2018

jos

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Introduction: Early childhood caries is defined as the presence of one or more decayed teeth, missing (due to caries) or filled teeth surface in a child 71 months of age or younger. The presence of Candida albicans will increase caries pathogenicity. Objectives: The objective of this study was to analyze the antifungal effectiveness of virgin coconut oil (VCO) mousse against viability of C. albicans biofilm in children with early childhood caries. Material and methods: In this experimental laboratory study, C. albicans biofilm was exposed to three concentrations of VCO mousse, namely 0.8%, 8% and 80%. C. albicans biofilm viability was tested using crystal violet 0.5% and a colony forming unit assay. Statistical analysis was conducted using 1-way ANOVA. Results: VCO mousse 80% showed optical density and total viable colony count (CFU/ml) values significantly different compared to VCO mousse 0.8% and 8% (p < 0.05). Conclusions: VCO mousse exhibited antifungal effect against viability of C. albicans biofilm in children with early childhood caries.

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“…They argue that caries-active children have more frequent and significantly larger amounts of spreptococci and candida when compared with caries-free children. Anther investigation reports candidal carriage among the early childhood caries group for 84% of cases, which is significantly higher than the non-early childhood caries group of 24% of cases [24]. Conversely, some studies do not find a difference in oral microbiota between caries-active and caries-free children [25].…”

Section: Resultsmentioning

confidence: 99%

Types of microorganisms in proximal caries lesion and ozone treatment

Kirilova

Topalova-Pirinska

Kirov

et al. 2019

Biotechnology & Biotechnological Equipment

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The purpose of this clinical study was to investigate the types of microorganisms in deep proximal caries lesions and the efficacy of elimination of microorganisms after a 24 s ozone application to proximal cavity lesions prepared for restoration. Sixteen caries-active volunteers (female: 8, male: 8; age range: 35-55), with proximally situated deep caries lesions on premolars or molars, were included in the study. Each patient underwent two microbiological investigations. First, the caries decay before treatment was assessed. Second, the dentine tissue was assessed after the removal of necrotic tooth decay and 24 s ozone application. The prevalence of oral streptococci was determined. In addition, we isolated Candida albicans, Enterococcus faecalis and Peptostreptococcus spp. from deep proximal caries lesion in caries-active patients. All microorganisms found in the deep proximal caries lesions were destroyed following 24 s ozone application. Our findings suggest that S. anginosus group, C. albicans and E. faecalis should be considered as an index for caries activity in caries-active patients, but additional studies are necessary to confirm this suggestion. This study demonstrated that 24 s of gaseous ozone application to the deep proximal caries lesions effectively eliminated microbial species.

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Comparison of Candida species isolated from children with and without early childhood caries: A descriptive cross-sectional study

Abstract: A significant correlation was found between the presence of Candida and ECC. NAC also plays an important role in the development of ECC. The virulence factors such as phospholipase may be responsible for the pathogenicity of Candida in the development of ECC.

Cited by 11 publications

References 1 publication

Antigen I/II mediates interactions between Streptococcus mutans and Candida albicans

Antigen I/II mediates interactions between Streptococcus mutans and Candida albicans

Antifungal effectiveness of virgin coconut oil mousse against Candida albicans biofilm in children with early childhood caries

Types of microorganisms in proximal caries lesion and ozone treatment

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