Comparison of carprofen and flunixin meglumine asadjunctive therapy in bovine respiratory disease

Balmer, T; Williams, Paulette; Selman, I.E.

doi:10.1016/s1090-0233(97)80028-7

Cited by 19 publications

(24 citation statements)

References 7 publications

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“…Treatment of BRD has been based predominantly on the use antimicrobial agents, with the main goals being rapid reduction of pyrexia 4 and improvement in clinical signs and pulmonary function 5 . Co‐administration of non‐steroidal anti‐inflammatory drugs (NSAIDs) as an adjunct to antimicrobial therapy has become common practice in the treatment of BRD during the past 25 years, because of their analgesic, antipyretic and anti‐inflammatory effects 6 .…”

mentioning

confidence: 99%

“…Co‐administration of non‐steroidal anti‐inflammatory drugs (NSAIDs) as an adjunct to antimicrobial therapy has become common practice in the treatment of BRD during the past 25 years, because of their analgesic, antipyretic and anti‐inflammatory effects 6 . Flunixin meglumine has been extensively used, as it was the first licensed NSAID in the early 1980s 4 . Other NSAIDs include carprofen, ketoprofen and meloxicam, which have been used in conjunction with different antibiotic agents in the treatment of BRD 5,7–9 .…”

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confidence: 99%

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Clinical efficacy of diclofenac sodium and flunixin meglumine as adjuncts to antibacterial treatment of respiratory disease of calves

et al. 2010

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confidence: 99%

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confidence: 99%

Clinical efficacy of diclofenac sodium and flunixin meglumine as adjuncts to antibacterial treatment of respiratory disease of calves

et al. 2010

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“…There was less lung consolidation in the three groups treated with an NSAID than in the animals treated with ceftiofur alone. Balmer et al . (1997) compared CPF and flunixin as adjunctive therapies in bovine respiratory disease.…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of carprofen as an adjunct to the antibacterial treatment of bovine respiratory disease

Elitok

2004

Vet Pharm & Therapeutics

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A clinical trial was undertaken to investigate the efficacy of a single dose of carprofen (CPF) in the treatment of bovine respiratory disease in cattle. Tilmicosin was used as a basal treatment in all animals. Six hours after dosing, body temperature and respiratory rates in animals treated with CPF-tilmicosin had decreased and were significantly lower than in the animals treated with tilmicosin alone (P < 0.05). Over the period of clinical observation, CPF-tilmicosin treatment produced a clinical resolution of the pneumonia similar to treatment with tilmicosin alone. However, it is significant from an animal welfare perspective that over the period of the study after treatment, CPF-tilmicosin therapy produced significantly greater symptomatic improvement than tilmicosin.

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“…Clinical parameters, observation grading and weighted numerical score included demeanour (normal = 2, depressed = 4, moribund = 8); appetite (normal = 2, depressed = 4, anorexic = 8); rectal temperature (<39.5 °C = 4, >39.5 °C but <40.5 °C = 8, >40.5 °C = 12); respiratory rate (per minute) (<35 = 3, 35-50 = 6, >50 = 9); type of respiration (normal = 1, dyspnoeic = 2); cough (absent = 1, present = 2); and nasal discharge (absent = 1, present = 2). Clinical index scores were calculated by adding up the weighted numerical scores from the animal's observation grade divided by the total weighted clinical score of 79 [17].…”

Section: Clinical Examinationmentioning

confidence: 99%

Cardiac Troponin-I Concentration In Weaned Calves With Bovine Respiratory Disease

et al. 2015

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The aim of this study was to evaluate the serum cardiac troponin I (cTnI) concentrations in weaned calves with moderate and severe bovine respiratory disease. Eighteen healthy weaned calves (group I), 18 weaned calves with moderate bovine respiratory disease (group II) and 18 weaned calves with severe bovine respiratory disease (group III) were included in the study. Clinical signs and severity of respiratory disease according to clinical index scores were determined. Blood cell counts and cardiac biomarkers, such as serum cTnI concentrations and creatine kinase-myocardial band (CK-MB), and lactate dehydrogenase (LDH) activities were determined in all groups. Temperature and respiratory and pulse rates were signifi cantly increased in calves with moderate and severe bovine respiratory disease compared to healthy calves (P < 0.05). Serum cTnI concentrations and LDH activities were signifi cantly increased in the calves with severe bovine respiratory disease compared to healthy calves and calves with moderate bovine respiratory disease (P < 0.05). A signifi cant increase in white blood cell counts in calves with moderate and severe bovine respiratory disease and lymphopenia and neutrophilia in calves with severe bovine respiratory disease were also found. The study suggests that severe bovine respiratory disease causes increased serum cTnI concentrations in weaned calves.

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Comparison of carprofen and flunixin meglumine asadjunctive therapy in bovine respiratory disease

Cited by 19 publications

References 7 publications

Clinical efficacy of diclofenac sodium and flunixin meglumine as adjuncts to antibacterial treatment of respiratory disease of calves

Clinical efficacy of diclofenac sodium and flunixin meglumine as adjuncts to antibacterial treatment of respiratory disease of calves

Clinical efficacy of carprofen as an adjunct to the antibacterial treatment of bovine respiratory disease

Cardiac Troponin-I Concentration In Weaned Calves With Bovine Respiratory Disease

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