Comparison of Clinical Characteristics of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Hospitalized Young Children

Taniguchi, Akinobu; Kawada, Junji; Go, Kiyotaka; Fujishiro, Naozumi; Hosokawa, Yosuke; Maki, Yuki; Sugiyama, Yasuo; Suzuki, Michio; Tsuji, Takeshi; Hoshino, Shin‐ichi; Muramatsu, Hideki; Kidokoro, Hiroyuki; Kinoshita, Fumie; Hirakawa, Akihiro; Takahashi, Yoshiyuki; Sato, Yoshiaki; Natsume, Jun

doi:10.7883/yoken.jjid.2018.480

Cited by 16 publications

(29 citation statements)

References 21 publications

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“…Along with respiratory syncytial virus (RSV) infections, hMPV is now recognized as a primary etiologic agent for acute upper and lower respiratory tract infections in pediatrics. [1617] In a study from Mexico, it was found that the number of hMPV infections increased in children aged 24–36 months as compared with those in younger age groups, whereas RSV infections were inversely proportional to increase in age. [9] Co-infection with both viruses can also occur, resulting in a more complicated and serious clinical disease.…”

Section: Introductionmentioning

confidence: 99%

Human metapneumovirus in pediatric patients with acute respiratory tract infections in the Aseer region of Saudi Arabia

Alsuheel

Ali

Al‐Hakami

et al. 2019

Saudi J Med Med Sci

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Background: Human metapneumovirus (hMPV) is a Paramyxovirus known to cause acute respiratory tract infections in children and young adults. To date, there is no study from the Aseer region of Saudi Arabia determining the proportion and severity of hMPV infection among pediatric hospitalized patients with respiratory infections. Objectives: The objective of this study is to determine the presence of hMPV antigens in the nasopharyngeal secretions of pediatric patients hospitalized with respiratory tract infections in the Aseer region of Saudi Arabia. Materials and Methods: This prospective, serological hospital-based study included all pediatric patients who were admitted to Aseer Central Hospital, Abha, Saudi Arabia, from July 2016 to November 2017 with upper and/or lower respiratory tract infections. Basic demographics of patients and their clinical data on and after admission were recorded. Direct fluorescent antibody assay was used to detect the presence of hMPV antigens in the obtained nasopharyngeal secretion specimens. Results: During the study, 91 pediatric patients were hospitalized due to upper and/or lower respiratory tract infections, of which 9.9% were positive for hMPV. These patients were aged 9 months to 16 years, were from Abha city or its surrounding localities and were mostly (77.8%) hospitalized during autumn or winter. The most common diagnosis on admission was bronchopneumonia (55.5%) and aspiration pneumonia (22.2%), and some patients also had underlying chronic conditions such as chronic heart disease (22.2%) and bronchial asthma (11.1%). Conclusions: The results obtained indicated that hMPV is a potential etiologic factor for the commonly occurring acute respiratory infections in hospitalized children from the Aseer region of Saudi Arabia. hMPV infection was also found to be associated with complicated respiratory conditions such as bronchopneumonia, chronic heart disease and bronchial asthma.

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Section: Introductionmentioning

confidence: 99%

Human metapneumovirus in pediatric patients with acute respiratory tract infections in the Aseer region of Saudi Arabia

Alsuheel

Ali

Al‐Hakami

et al. 2019

Saudi J Med Med Sci

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“…In the present study, HMPV was detected from a nasal swab of a 71-year-old patient with pneumonia. HMPV is one of the most significant causes of upper and lower respiratory tract infections in children and the elderly, especially the immunocompromised and those with underlying respiratory conditions (Oong et al, 2018;Taniguchi et al, 2019;Jallow et al, 2019). Two genotypes of HMPV have been identified, which can be classified into five lineages, A1, A2a, A2b, B1, and B2.…”

Section: Discussionmentioning

confidence: 99%

Detection of multiple viral sequences in the respiratory tract samples of suspected Middle East respiratory syndrome coronavirus patients in Jakarta, Indonesia 2015–2016

Setianingsih¹,

Wiyatno²,

Hartono³

et al. 2019

International Journal of Infectious Diseases

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“…However, the roles of 5-LOX and COX-2 in HMPV infection are still unknown. Nonetheless, montelukast, a selective CysLT1R antagonist, has been used to treat HMPV infection of hospitalized young children ( 113 ). A high-throughput sequencing study of HMPV-infected A549 cells shows upregulation of let-7f ( 108 ).…”

Section: Linkages Between Mirnas and Leukotrienes During Other Respiratory Virus Infectionsmentioning

confidence: 99%

miRNAs and Leukotrienes in Respiratory Syncytial Virus Infection

Fan

et al. 2021

Front. Pediatr.

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MicroRNAs (miRNAs) are small, non-coding RNAs that regulate posttranscription by binding to 3′-untranslated regions of target mRNAs. Recent functional studies have elucidated mechanisms that miRNAs regulate leukotriene synthesis by perturbing arachidonic acid metabolism. Both microarrays and high-throughput sequencing revealed distinct differential expression of miRNAs in children with respiratory syncytial virus (RSV) infection compared with healthy controls. Abnormal miRNA expression may contribute to higher leukotriene levels, which is associated with airway hyperreactivity. Targeting miRNAs may benefit to restore the homeostasis of inflammatory reaction and provide new strategies to alleviate airway hyperreactivity induced by RSV. In this article, we provide an overview of the current knowledge about miRNAs modulating leukotrienes through regulation of arachidonic acid metabolism with a special focus on miRNAs aberrantly expressed in children with RSV infection.

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Comparison of Clinical Characteristics of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Hospitalized Young Children

Cited by 16 publications

References 21 publications

Human metapneumovirus in pediatric patients with acute respiratory tract infections in the Aseer region of Saudi Arabia

Human metapneumovirus in pediatric patients with acute respiratory tract infections in the Aseer region of Saudi Arabia

Detection of multiple viral sequences in the respiratory tract samples of suspected Middle East respiratory syndrome coronavirus patients in Jakarta, Indonesia 2015–2016

miRNAs and Leukotrienes in Respiratory Syncytial Virus Infection

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