This study analyzes the irrigation water requirement of wheat in the growth stage in the Beijing-Tianjin-Hebei region under the changes of meteorological factors conditions, using the growth period data, and meteorological data from 80 meteorological stations, from 2000 to 2019. The results show that: (1) The annual average precipitation, average wind speed, and average relative humidity of the growth period in the Beijing-Tianjin-Hebei region show a downward variation trend, while the temperature variation shows an upward trend. Moreover, relative humidity and radiation exhibit a negative spatial correlation. (2) Wheat irrigation water requirement in the Beijing-Tianjin-Hebei region gradually decreases from north to south and east to west. However, the eastern region shows a gradually increasing trend, while the western region shows a decreasing trend. (3) Meteorological factors are negatively correlated with irrigation water requirement, potential evapotranspiration, effective precipitation, and relative humidity, and significantly positively correlated with sunshine hours, average temperature, and wind speed. The overall variation in irrigation water requirement has the highest correlation with potential evapotranspiration. However, the yearly variations in regional irrigation water requirement are dependent on factors such as wind speed, relative humidity, and radiation.