Comparison of Coronary Heart Disease Mortality in Men and Women Age 50 Years and Older in Russia and Usa

Бойцов, С. А.; Зайратьянц, О. В.; Andreev, Evgeny; Самородская, И. В.

doi:10.15829/1560-4071-2017-6-100-107

Cited by 26 publications

(15 citation statements)

References 7 publications

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“…Ишемическая болезнь сердца (ИБС) стоит на первом месте среди болезней системы кровообращения (БСК). Согласно статистическим данным Всемирной организации здравоохранения в Российской Федерации по сравнению со странами Евросоюза и Соединенных Штатов Америки (США) имеет место значительное превышение показателей смертности от БСК, в том числе ИБС [1]. Стандартизованный коэффициент смертности (СКС) от всех форм ИБС среди мужчин в возрасте 50 лет и старше в России составил 2153,1 в США 712,6, а среди женщин, соответственно -1288,3 и 421,2 [1].…”

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The results of intramyocardial implantation of autologous bone marrow cells treated with erythropoietin in the surgical treatment of coronary artery disease with severe lesion of vessels

et al. 2019

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Aim. To assess safety and efficacy of intramyocardial implantation of autologous bone marrow cells treated with erythropoietin in surgery for coronary artery disease (CAD).Materials and methods. Eighty patients with CAD with diffuse and (or) distal lesions of the right coronary artery were randomly assigned to two groups: patients of group 1 (n=40) underwent coronary bypass surgery, implantation of autologous bone marrow cells treated with erythropoietin into the lower wall of the left ventricle, patients of group 2 (control group, n=40) underwent bypass surgery of the left coronary artery. Evaluation of the clinical status, perfusion and contractility of the myocardium was performed initially, 6 and 12 months after surgery.Results. Six months after the operation, we found more pronounced decrease of functional class (FC) of angina and improvement in the 6-min walk distance in the main group compared with the control group.Twelve months after surgery, the severity of angina remained at the same level in both groups. In the control group, 45,2% of patients had FC I, 52,3% of patients did not have angina. In both groups, angina return was detected in 1 patient (FC III). According to the results of two-step myocardial scintigraphy with Technetril (Tc99), 6 months after surgery, a significant improvement in myocardial perfusion was observed. In the control group, after 6 months, no significant dynamics of perfusion of the lower wall of the left ventricle was detected.Twelve months after the surgical treatment of the right coronary artery in patients from the group 1 revealed a decrease in the stress defect and the stable perfusion defect. In patients from the control only a significant stress defect was found to decrease.Conclusion. The study demonstrated decrease of FCs, significant improvement in perfusion, functional state of the myocardium and 6-min walk distance in patients of group 1.

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Section: Discussionunclassified

The results of intramyocardial implantation of autologous bone marrow cells treated with erythropoietin in the surgical treatment of coronary artery disease with severe lesion of vessels

et al. 2019

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“…Ишемическая болезнь сердца (ИБС) в настоящее время остается ведущей причиной смертности населения в экономически развитых странах, в том числе в Российской Федерации [1]. «Золотым стандартом» диагностики ИБС является коронароангиография (КАГ), однако, ввиду инвазивности и технической сложности, она должна проводиться только пациентам высокого риска ИБС, у которых другие методы диагностики не информативны [2].…”

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Comparison of myocardial contrast stress-echocardiography and standard stress-echocardiography in detecting myocardial ischemia in patients with different severity of coronary artery stenoses

Atabaeva

Saidova

Шитов

et al. 2020

Terapevticheskii arkhiv

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Aim. To compare diagnostic value between standard stress-echocardiography and myocardial contrast stress echocardiography in detection of myocardial ischemia in patients with different severity of coronary artery stenoses. Materials and methods. Myocardial contrast stress-echocardiography and standard stress-echocardiography were performed in 38 patients with coronary artery stenoses over 50% by angiography. Of all lesions 39 were intermediate (5075%) and 33 over 75% stenoses. Fractional flow reserve (FFR) was measured in 12 coronary arteries. During myocardial contrast stress-echocardiography wall motion and myocardial perfusion was assessed. Results. Adequate visualisation increased from 81.6% in unenhanced segments to 96.1% in contrast-enhanced segments. The sensitivity, specificity, and diagnostic accuracy of standard stress-echocardiography and myocardial contrast stress-echocardiography in intermediate (5075%) coronary stenoses were 44%, 83%, 56% and 56%, 94% и 64% respectively compare to angiography. Taking into account the 12 arteries with evaluated FFR, these parameters increased to 52%, 93% и 65% in standard stress-echocardiography and to 68%, 100% and 75% in myocardial contrast stress-echocardiography. In coronary stenoses over 75% the sensitivity, specificity, and diagnostic accuracy of standard stress-echocardiography and myocardial contrast stress-echocardiography were 78%, 88%, 80% and 86%, 100%, 92% respectively Conclusion. Use of contrast-enhanced stress-echorardiography significantly increased the diagnostic value of this method by improving endocardial border visualization and possibilities of myocardial perfusion assessment.

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“…In 2017, 53.3% lethal outcomes in the Russian Federation are attributed to CHD (Boytsov et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Forming statin response in patients with coronary heart disease in presence of acute respiratory viral infections by means of genetic markers

Маль¹,

Gribovskaya²

2018

RRP

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Introduction. The present study evaluated the interaction of statin response and genetic polymorphism of interleukin (IL-1β, IL-6, IL-4, IL-10) genes with the course of atherosclerosis and coronary heart disease (CHD) in patients with CHD combined with acute respiratory viral infections (ARVI). Objectives. Studying variability of Rosuvastatin response in patients with CHD combined with ARVI, taking cytokine gene polymorphism into account. Materials and methods. Detection of lipid metabolism parameters and interleukin levels in blood serum; verification of causative agents of the infectious process. Genotyping of polymorphisms IL-1β –511C>T, IL-6 –174G>C, IL-4 –589C>T, IL-10 –1082G>А. Statistical processing in Microsoft Office Excel 2007 software. Results and discussion. In CHD patients at Visit I, the target level of low-density lipoprotein cholesterol (LDL-C) was reached by 55.7% of participants. At Visit II, the target LDL-C level was reached by 49.7% of patients, which coincided with ARVI detection in some patients. In CHD patients with ARVI at Visit II, the IL-1β level increased to 33.00 pg/ml (N=5.00 pg/ml), IL-6 – 19.20 pg/ml (N=9.00 pg/ml); at Visit VI those levels decreased to 20.70 pg/ml and 12.80 pg/ml. The IL-4 level was 8.30 pg/ml (N=13.00 pg/ml), while IL-10 level was 19.40 pg/ml (N=31.00 pg/ml), with their increase at Visit VI to 15.80 pg/ml and 33.50 pg/ml. CHD patients without ARVI did not develop interleukin level changes. At Visit II, the IL-1β level was 10.30 pg/ml, IL-6 level was 12.40 pg/ml, and at Visit VI, they were 13.00 pg/ml and 14.00 pg/ml. The IL-4 and IL-10 levels at Visit II were 19.70 pg/ml and 32.30 pg/ml; at Visit VI, those levels were 23.20 pg/ml and 34.20 pg/ml. The following associations were demonstrated: –511CT / increased IL-1β, LDL-C synthesis; –511СС / LDL-C level increase; –174GG / IL-6, LDL-C level increase; –1082GG / IL-10 level increase, cholesterol and CRP level decrease; –589ТТ / CRP, IL-4 level increase. Conclusion. Genotypes –511CT, –174GG, –1082AA in all patients required 20 mg/day Rosuvastatin dose to reach the target LDL-C level.

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Comparison of Coronary Heart Disease Mortality in Men and Women Age 50 Years and Older in Russia and Usa

Cited by 26 publications

References 7 publications

The results of intramyocardial implantation of autologous bone marrow cells treated with erythropoietin in the surgical treatment of coronary artery disease with severe lesion of vessels

The results of intramyocardial implantation of autologous bone marrow cells treated with erythropoietin in the surgical treatment of coronary artery disease with severe lesion of vessels

Comparison of myocardial contrast stress-echocardiography and standard stress-echocardiography in detecting myocardial ischemia in patients with different severity of coronary artery stenoses

Forming statin response in patients with coronary heart disease in presence of acute respiratory viral infections by means of genetic markers

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