Comparison of different doses of daily iron supplementation for anemia prophylaxis in pregnancy: A systematic review

Yadav, Kapil; Arjun, M C; Jacob, Olivia Marie; Kant, Shashi; Ahamed, Farhad; Ramaswamy, Gomathi

doi:10.4103/jfmpc.jfmpc_960_19

Cited by 9 publications

(7 citation statements)

References 36 publications

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“…This agrees with result of Judith 8 who suggests that maternal age and parity were independently associated with maternal anemia. This is also consistent with the findings of Yadav et al 7 in which gravidity was not a significant predictor of Hb concentration. This result was not in agreement with Upadhyay et al 9 study that showed a significant relationship between parity and severity of anemia.…”

Section: Discussionsupporting

confidence: 93%

“…Iron supplementation decreases the prevalence of maternal anemia at delivery. 7 In this research, there was no statistically substantial variation in the mean age and parity in between mild, moderate and severe iron deficiency anemic pregnant females. This agrees with result of Judith 8 who suggests that maternal age and parity were independently associated with maternal anemia.…”

Section: Discussionmentioning

confidence: 51%

See 1 more Smart Citation

Effect of maternal iron deficiency anemia on fetal hemodynamics and pregnancy outcome

othman¹,

Ismail²,

Abdel-Aziz³

2021

Al-Azhar International Medical Journal

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 51%

Effect of maternal iron deficiency anemia on fetal hemodynamics and pregnancy outcome

othman¹,

Ismail²,

Abdel-Aziz³

2021

Al-Azhar International Medical Journal

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“…There are some indications from observational studies that not only iron deficiency but also iron excess negatively affects the child’s neurodevelopment [ 18 , 32 , 33 , 35 , 36 ] and, based on that, some main researchers in this field have proposed to adapt the prenatal iron supplementation to the individual’s requirements to mitigate the potential damage from any maternal iron imbalance [ 22 , 23 , 25 , 41 ]. However, few studies have tested this hypothesis, obtaining inconsistent results [ 37 , 61 ]. We observed that our intervention successfully corrected maternal iron status when compared with the estimates of the prevalence of anaemia and haemoconcentration during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Adapting prenatal iron supplementation to maternal needs results in optimal child neurodevelopment: a follow-up of the ECLIPSES Study

Iglesias-Vázquez

Hernández‐Martínez

Voltas

et al. 2022

BMC Pregnancy Childbirth

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Background Prenatal prescription of standard iron supplements to prevent iron deficiency appears not to be appropriate for all women and their children, as some women may be at risk of iron deficiency and others at risk of iron excess early in pregnancy. The present study aimed to assess whether prenatal iron supplementation adapted to the needs of each pregnant woman affects their child’s neurodevelopment. Methods Follow-up of a community-based RCT involving 503 mother–child pairs. Non-anaemic pregnant women recruited in Tarragona (Spain) early in pregnancy were prescribed a daily iron dose based on their initial haemoglobin levels: Stratum 1 (Hb = 110–130 g/L, 80 or 40 mg/d of iron) and Stratum 2 (Hb > 130 g/L, 40 or 20 mg/d of iron). Women receiving 40 mg/d were considered the control group in each Strata . The child’s neurodevelopment was assessed at 40 days of age using the Bayley Scales of Infant Development-III (BSID-III). Adjusted multiple regression models were used. Results Multiple regression analyses showed no association between the intervention and control group within each Strata on the BSID-III scores on any of the developmental scales in children, including cognitive, language, and motor development: Stratum 1 (β 1.46, 95%CI -2.15, 5.07; β 1.30, 95%CI -1.99, 4.59; and β 2.04, 95%CI -3.88, 7.96, respectively) and Stratum 2 (β -4.04, 95%CI -7.27, 0.80; β -0.36, 95%CI -3.47, 2.75; and β -3.76, 95%CI -9.30, 1.78, respectively). Conclusions In non-anaemic women in early pregnancy, no differences were found in the cognitive, language and motor development of children at 40 days of age between the dose of iron tested in each case –adjusted to initial Hb levels– compared to the dose of the control group. Further studies are guaranteed to confirm our findings. Trial registration The ECLIPSES study was registered at www.clinicaltrialsregister.eu as EudraCT number 2012–005,480-28. Supplementary Information The online version contains supplementary material available at 10.1186/s12884-022-05033-y.

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“…In developing countries, overall nutritional improvement and excessive doses of iron for the prevention of anaemia may be factors that increase the incidence rates of diabetes and GDM. 76 However, this is not evidence against recommending iron supplementation to correct maternal anaemia. Hence, it is essential to conduct rigorous RCTs to determine the dosage and duration of iron supplementation for pregnant women with anaemia and those without anaemia to avoid iron overload.…”

Section: Association Of Haemoglobin As a Biomarker Of Iron Supplement...mentioning

confidence: 99%

Impact of iron supplementation on gestational diabetes mellitus: A literature review

Liu

Feng

Yan

et al. 2022

Diabetes Obesity Metabolism

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Gestational diabetes mellitus (GDM) is a common complication of pregnancy, affecting 14% of pregnancies worldwide, and the prevention of pathological hyperglycaemia during pregnancy is meaningful for global public health. The role of iron supplementation in the progression of GDM has been of significant interest in recent years. Iron is a micronutrient that is vital during pregnancy; however, given the toxic properties of excess iron, it is probable that prophylactic iron supplementation will increase the risk of adverse pregnancy outcomes, including GDM. It is critical to clarify the effect of iron supplementation on the risk of GDM. Therefore, in this review, we comprehensively assess the role of iron in pregnancy. This review aimed to analyse the necessity of iron supplementation and maintenance of iron homeostasis during pregnancy, particularly reviewing the role and function of iron in beta cells and examining the mechanisms of excess iron contributing to the pathogenesis of GDM. Moreover, we aimed to discuss the association of haemoglobin and ferritin with GDM and identify priority areas for research.

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Comparison of different doses of daily iron supplementation for anemia prophylaxis in pregnancy: A systematic review

Cited by 9 publications

References 36 publications

Effect of maternal iron deficiency anemia on fetal hemodynamics and pregnancy outcome

Effect of maternal iron deficiency anemia on fetal hemodynamics and pregnancy outcome

Adapting prenatal iron supplementation to maternal needs results in optimal child neurodevelopment: a follow-up of the ECLIPSES Study

Impact of iron supplementation on gestational diabetes mellitus: A literature review

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