biomedicalresearch 2019
DOI: 10.35841/biomedicalresearch.30-19-027
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Comparison of different models of insulin resistance in T2DM: A crosssectional study.

Abstract: Introduction: Type 2 diabetes mellitus is a metabolic disease characterized by insulin resistance and defective insulin secretion. Quantification of insulin resistance is essential as it may guide treatment options. The aim of the study was to compare HOMA-IR (both insulin and C-peptide based) and QUICKI in type 2 diabetes mellitus patients. Methodology: The cross-sectional study included a hundred and fourteen type 2 DM patients diagnosed as per the American Diabetic Association 2017 guidelines. Fasting blood… Show more

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Cited by 2 publications
(3 citation statements)
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“…There was no correlation between insulin-based HOMA-IR and C-peptide based HOMA-IR. This is contrary to findings from India that reported a significantly positive linear correlation in type 2 diabetes mellitus (T2DM) patients, even though it was weak [19]. This disparity could be explained by numerous factors, the difference in insulin assay methods being one of them.…”
Section: Discussioncontrasting
confidence: 92%
See 1 more Smart Citation
“…There was no correlation between insulin-based HOMA-IR and C-peptide based HOMA-IR. This is contrary to findings from India that reported a significantly positive linear correlation in type 2 diabetes mellitus (T2DM) patients, even though it was weak [19]. This disparity could be explained by numerous factors, the difference in insulin assay methods being one of them.…”
Section: Discussioncontrasting
confidence: 92%
“…This disparity could be explained by numerous factors, the difference in insulin assay methods being one of them. In this study from India [19], insulin was assayed using an automated biochemistry analyser based on electrochemiluminescence, meanwhile in our study, insulin was assayed using the ELISA sandwich principle. It is suggested that different assay methods/kits may show significant variations in insulin levels [20].…”
Section: Discussionmentioning
confidence: 99%
“…Only C-peptide and IR indices derived from it correlated with 25OHD. The explanation could be by the fact the C-peptide has a longer plasmatic half-life and it doesn’t go through hepatic extraction, thus showing better the pre-hepatic beta-cell insulin secretion, as highlighted for T2DM patients [ 44 ].…”
Section: Discussionmentioning
confidence: 99%