Comparison of digestibility and breath hydrogen gas excretion of fructo-oligosaccharide, galactosyl-sucrose, and isomalto-oligosaccharide in healthy human subjects

Oku, Tsuneyuki; Nakamura, Shin

doi:10.1038/sj.ejcn.1601666

Cited by 89 publications

(44 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The metabolic pathway in the human gastrointestinal tract of nondigestible sugar substitutes is as follows: they escape digestion and absorption in the small intestine, and supply energy to the host via fermentation by microbes in the large intestine (Tokunaga et al, 1989;Noda and Oku, 1992). The main products of the microbes' fermentation are short chain fatty acids, such as acetate, propionate, and n-butyrate, hydrogen, methane and carbon dioxide (Wursch et al, 1989;Reaugerie et al, 1990;Cummings and Macfarlane, 1991;Natah et al, 1997;Oku and Nakamura, 2003). Non-digestible sugar substitutes directly or indirectly bring about beneficial health effects during their passage through the gastrointestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans

et al. 2007

Self Cite

View full text Add to dashboard Cite

Objectives: To estimate the suppressive effect of partially hydrolyzed guar gum (PHGG) on transitory diarrhea induced by ingestion of a sufficient amount of maltitol or lactitol in female subjects. Design: The first, the minimal dose level of maltitol and lactitol that would induce transitory diarrhea was estimated separately for each subject. Individual subject was administered a dose that increased by 5 g stepwise from 10 to 45 g until diarrhea was experienced. Thereafter, the suppressive effect on diarrhea was observed after each subject ingested a mixture of 5 g of PHGG and the minimal dose level of maltitol or lactitol. Setting: Laboratory of Public Health Nutrition, Department of Nutrition and Health Sciences, Siebold University of Nagasaki. Subjects: Thirty-four normal female subjects (21.370.9 years; 49.575.3 kg). Main outcome measurement: Incidence of diarrhea caused by the ingestion of maltitol or lactitol and the ratio of suppression achieved by adding PHGG for diarrhea. Results: The ingestion of amounts up to 45 g of maltitol, diarrhea caused in 29 of 34 subjects (85.3%), whereas the ingestion of lactitol caused diarrhea in 100%. The diarrhea owing to maltitol was improved in 10 of 28 subjects by the addition of 5 g of PHGG to minimal dose-induced diarrhea, and that owing to lactitol was in seven of 19 subjects. Adding 10 g of PHGG strongly suppressed the diarrhea caused by maltitol, and the cumulative ratio was 82.1% (23/28). Conclusion: The transitory diarrhea caused by the ingestion of maltitol or lactitol was clearly suppressed by the addition of PHGG. These results strongly suggest that diarrhea caused by the ingestion of a sufficient amount of non-digestible sugar substitute can be suppressed by the addition of dietary fiber.

show abstract

Section: Introductionmentioning

confidence: 99%

Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans

et al. 2007

Self Cite

View full text Add to dashboard Cite

show abstract

“…Outros oligossacarídeos, como a lactosacarose, os isomaltooligossacarídeos (IMOs), galacto-oligossacarídeos (GOs), transgalacto-oligossacarídeos (TGOs), rafinose, estaquiose também têm recebido atenção, visto que podem atuar como fatores de crescimento para bifidobactérias e são utilizados em vários alimentos (ONISHI;TANAKA, 1998;URA, 2003;ALMEIDA;PASTORE, 2004;YAMASHITA et al, 2005).…”

Section: Funções Dos Oligossacarídeos Na Dietaunclassified

Produção, propriedades e aplicações de oligossacarídeos

et al. 2011

View full text Add to dashboard Cite

ResumoOs oligossacarídeos participam da constituição da fibra alimentar e são principalmente utilizados como prebióticos. Esta revisão apresenta as vias de obtenção destes açúcares, os quais podem ser produzidos por síntese (química ou enzimática) ou da despolimerização de polissacarídeos (física, química ou enzimática), como descrito na presente revisão. Os oligossacarídeos vêm sendo utilizados comercialmente como ingredientes de cosméticos, medicamentos, produtos agrícolas e principalmente na indústria alimentícia. O potencial de aplicações dos oligossacarídeos nessas áreas nas mais diversas áreas tais como alimentos, rações animais, fármacos e cosméticos tem contribuído para o aumento das investigações científicas. O uso de oligossacarídeos como agentes imunomoduladores e modificadores de respostas biológicas foi recentemente descrito, assim como seus efeitos como compostos antiinflamatórios e hipocolesterolêmicos. Uma visão geral sobre as diversas funções nutracêuticas e biológicas destes oligômeros de carboidratos visando benefícios para a saúde humana também foi reportada. Palavras-chave: Oligossacarídeos. Fibras da dieta. Saúde humana. AbstractOligosaccharides participate in the formation of dietary fiber and are mainly used as prebiotic agents. This review presents ways of obtaining these sugars, which can be produced by synthesis (chemical or enzymatic), or through depolymerization of polysaccharides (physical, chemical or enzymatic). Oligosaccharides have also been used commercially as an ingredient in cosmetics, pharmaceuticals, agricultural products and especially in the food industry because of their physical properties. The potential applications of oligosaccharides in several areas such as food, animal feed, pharmaceuticals and cosmetics have contributed to the increase in scientific research on these carbohydrates. The use of oligosaccharides as immuno-modulatory agents and biological response modifiers has been recently described, and their effects as anti-inflammatory and in reducing cholesterol. An overview of the various nutraceutical and biological functions of these carbohydrates in order to benefit human health is also reported.

show abstract

“…They are resistant to small intestinal digestion because of the inability of human gastrointestinal enzymes to hydrolyse the b2-1 glycosidic bonds between the fructose monomers (Oku & Nakamura, 2003). FOS have therefore shown high recovery rates in ileostomy effluent (Ellegard et al 1997).…”

Section: Prebiotics In Enteral Tube Feedingmentioning

confidence: 99%

Enteral-tube-feeding diarrhoea: manipulating the colonic microbiota with probiotics and prebiotics

Whelan

2007

Proc. Nutr. Soc.

View full text Add to dashboard Cite

Diarrhoea is a common and serious complication of enteral tube feeding. Its pathogenesis involves antibiotic prescription, enteropathogenic colonization and abnormal colonic responses, all of which involve an interaction with the colonic microbiota. Alterations in the colonic microbiota have been identified in patients receiving enteral tube feeding and these changes may be associated with the incidence of diarrhoea. Preventing negative alterations in the colonic microbiota has therefore been investigated as a method of reducing the incidence of diarrhoea. Probiotics and prebiotics may be effective because of their suppression of enteropathogenic colonization, stimulation of immune function and modulation of colonic metabolism. Randomized controlled trials of probiotics have produced contrasting results, althoughSaccharomyces boulardiihas been shown to reduce the incidence of diarrhoea in patients in the intensive care unit receiving enteral tube feeding. Prebiotic fructo-oligosaccharides have been shown to increase the concentration of faecal bifidobacteria in healthy subjects consuming enteral formula, although this finding has not yet been confirmed in patients receiving enteral tube feeding. Furthermore, there are no clinical trials investigating the effect of a prebiotic alone on the incidence of diarrhoea. Further trials of the efficacy of probiotics and prebiotics, alone and in combination, in preventing diarrhoea in this patient group are warranted.

show abstract

Comparison of digestibility and breath hydrogen gas excretion of fructo-oligosaccharide, galactosyl-sucrose, and isomalto-oligosaccharide in healthy human subjects

Cited by 89 publications

References 27 publications

Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans

Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans

Produção, propriedades e aplicações de oligossacarídeos

Enteral-tube-feeding diarrhoea: manipulating the colonic microbiota with probiotics and prebiotics

Contact Info

Product

Resources

About