Comparison of effects of octopamine and insecticidal essential oils on activity in the nerve cord, foregut, and dorsal unpaired median neurons of cockroaches

Price, David; Berry, Michael S.

doi:10.1016/j.jinsphys.2005.11.010

Cited by 114 publications

(67 citation statements)

References 38 publications

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“…The compounds p-cymene, eugenol, trans-anethole, vanillin, and isoeugenol were found to be antagonists of octopamine receptor [51], whereas in another study, from the electrophysiology point of view, eugenol did not show any antagonist activity [107]. Hence, there is no agreement about whether insecticidal activity of eugenol is directly related to its interaction with the octopamine receptor [51,107,108]. Chlordimeform, methomyl, permethrin, chlorfluazuron, malathion, trichlorfon, and some oxazolidine had agonistic effects, and eugenol, cinnamic alcohol, and phenyl methyl alcohol produced an increase in octopamine production in the German cockroach [109].…”

Section: Octopaminergic Sitesmentioning

confidence: 80%

“…While thymol had no effect, its isomer carvacrol acted as an agonist at a concentration of 2 nmol/mL. The compounds p-cymene, eugenol, trans-anethole, vanillin, and isoeugenol were found to be antagonists of octopamine receptor [51], whereas in another study, from the electrophysiology point of view, eugenol did not show any antagonist activity [107]. Hence, there is no agreement about whether insecticidal activity of eugenol is directly related to its interaction with the octopamine receptor [51,107,108].…”

Section: Octopaminergic Sitesmentioning

confidence: 83%

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Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study

Dambolena

Zunino

Herrera

et al. 2016

Psyche: A Journal of Entomology

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Many insects affect food production and human health, and in an attempt to control these insects the use of synthetic insecticides has become widespread. However, this has resulted in the development of resistance in these organisms, human diseases, contamination of food, and pollution of the environment. Plants natural products and essential oil components such as terpenes and phenylpropenes have been shown to have a significant potential for insect control. However, the molecular properties related to their insecticidal activity are not well understood. The purpose of this review is to provide an overview of the toxicity of terpene compounds against three insects of importance to human health: lice, cockroaches, and Triatominae bugs and to evaluate which molecular descriptors are important in the bioactivity of terpenes. For the insects studied, quantitative structure-activity relationship (QSAR) studies were performed in order to predict the insecticidal activity of terpene compounds. The obtained QSAR models indicated that the activity of these compounds depends on their ability to reach the targets and to interact with them. The QSAR analysis can be used to predict the bioactivities of other structurally related molecules. Our findings may provide an important contribution in the search for new compounds with insecticidal activity.

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Section: Octopaminergic Sitesmentioning

confidence: 80%

Section: Octopaminergic Sitesmentioning

confidence: 83%

Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study

Dambolena

Zunino

Herrera

et al. 2016

Psyche: A Journal of Entomology

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“…Various studies have indicated that monoterpenoids may have several mechanisms of action. Mechanisms that have been reported include: inhibition of acetylcholinesterase (5,6), binding at the GABA receptor (7)(8)(9)(10)(11), binding at the nicotinic acetylcholine receptor (12), the octopamine receptor (13,14), and the tyramine receptor (15). Previous studies have also described quantitative structure-activity relationships (QSARs) to describe the toxicity of monoterpenoids and their interaction at the GABA receptor (11).…”

mentioning

confidence: 99%

Quantitative Structure-Activity Relationships (QSARs) of Monoterpenoids at an Expressed American Cockroach Octopamine Receptor

Gross

Kimber

Day

et al. 2013

ACS Symposium Series

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Monoterpenoids are found in essential oils from numerous plant families. Octopamine is a biogenic monoamine found within various invertebrates, including insects. Octopamine exerts its physiological effects through the activation of G-protein-coupled receptors (GPCRs). GPCRs are an under-utilized receptor target in the agrochemical industry. Here we report the expression of an octopamine receptor from the brain of the American cockroach (Periplaneta americana) inSaccharomyces cerevisiae, creating a ligand-independent histidine-auxotrophic assay. The majority of monoterpenoids acted as an inverse agonist in this system. Three QSAR models show that electronic properties are most important for monoterpenoid interaction with this octopamine receptor in this yeast assay.

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“…The physiological actions of essential oils on insects are little known, but treatments with various essential oils or their constituents cause symptoms similar to a neurotoxic mode of action. 18 Previous reports by several groups found that some essential oils inactivated an octopamine receptor binding site and disrupted cAMP production of invertebrates, and then induced symptoms similar to those of neurotoxicity against insects. 19 The termites treated with E. camaldulensis leaf oils seem to partly exhibit the symptoms relating to an inhibition of octopamine functions.…”

Section: Discussionmentioning

confidence: 99%

Biological performance of Eucalyptus camaldulensis leaf oils from Thailand against the subterranean termite Coptotermes formosanus Shiraki

2009

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The antitermitic activities of leaf oils and their constituents, taken from three clones of Eucalyptus camaldulensis Dehnh. in Thailand, against Coptotermes formosanus Shiraki were investigated in contact and noncontact tests. The termiticidal mechanism was also examined. Antitermitic tests demonstrated that E. camaldulensis leaf oils were both contact toxicants and fumigants to C. formosanus with LC 50 values ranging between 12.68 and 17.50 mg/ g by the contact method, and between 12.65 and 17.50 mg/ petri dish (100 cm 3 ) by the noncontact method. p-Cymene and g-terpinene were primarily responsible for the contact toxicity and 1,8-cineole was responsible for fumigation. From the investigation of termiticidal mechanism, E. camaldulensis leaf oils exhibited the inhibition of acetylcholinesterase activity and showed the common symptoms of a neurotoxic mode of action against C. formosanus.

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Comparison of effects of octopamine and insecticidal essential oils on activity in the nerve cord, foregut, and dorsal unpaired median neurons of cockroaches

Cited by 114 publications

References 38 publications

Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study

Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study

Quantitative Structure-Activity Relationships (QSARs) of Monoterpenoids at an Expressed American Cockroach Octopamine Receptor

Biological performance of Eucalyptus camaldulensis leaf oils from Thailand against the subterranean termite Coptotermes formosanus Shiraki

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