Comparison of effects of the tacrolimus and cyclosporine A on the colon anastomosis recovery of rats

Uysal, Erdal; Dokur, Mehmet

doi:10.4174/astr.2017.92.6.402

Cited by 7 publications

(5 citation statements)

References 27 publications

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“…There were statistically significant differences among bursting pressures of groups (P<0.001). The value was significantly lower in tacrolimus group compared to control group (P<0.001) [24].…”

Section: хирургическая гастроэнтерология Surgical Gastroenterologymentioning

confidence: 77%

“…According to their investigations preoperative serum protein was the only independent risk factor for anastomotic failure (p<0.0001, OR 0.6 per g/dL) [ 2021) have demonstrated some medication use may affect the development of AL. According to their study results the use of corticosteroids and some immunosuppressive medicines may delay and impair anastomotic healing [14,24,25].…”

Section: хирургическая гастроэнтерология Surgical Gastroenterologymentioning

confidence: 99%

“…This finding is supported by other studies showing that use of immunosuppressive drugs increases the risk of anastomotic leakage in colorectal surgery. Uysal et al (2017) studied the effects of preoperative treatment with immunosuppressant cyclosporine A and tacrolimus on colon anastomosis recovery. Their study showed that tacrolimus and cyclosporine A might have a negative effect on colon anastomosis recovery.…”

Section: хирургическая гастроэнтерология Surgical Gastroenterologymentioning

confidence: 99%

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Preoperative Risk Factors for Anastomotic Leaks in Colorectal Surgery

Исмаилова¹,

Агаев²,

Israfilova³

2022

Хирургия. Восточная Европа

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Основной целью настоящего обзора является систематический анализ мировой литературы по проблеме несостоятельности анастомоза, определение предоперационных факторов риска этого осложнения и изучение связи этих факторов с несостоятельностью анастомоза после открытой или лапароскопической колоректальной хирургии. В статье представлена клиническая классификация степени тяжести (степень А, В и С) несостоятельности анастомоза. Оценивались данные об общем состоянии пациентов, основном и сопутствующих заболеваниях, а также о предоперационной подготовке желудочно-кишечного тракта. Были подробно изучены предоперационные факторы риска несостоятельности, основными из которых являются мужской пол, курение и частое употребление алкоголя, предоперационная анемия, гипопротеинемия и гипоальбуминемия, высокий индекс массы тела, пожилой и старческий возраст, предоперационная химиотерапия и лучевая терапия, длительное лечение кортикостероидами, отсутствие механической подготовки кишечника и пероральной антибиотикотерапии. Anastomotic leak remains a severe complication after colorectal surgery with considerable morbidity, higher rate of reoperations, and higher mortality. There is generally accepted idea that arterial ischemia or tension in the anastomotic line will lead to healing complications. But it’s noteworthy that even well perfused, under no tension anastomoses may develop leakage, hence it continues to be a challenging issue in colorectal surgery. Over the past several decades of investigation are determined a lot of preoperative, intraoperative and postoperative risk factors for anastomotic leak, as well as, some conclusive recommendations are justified, whereas others are still open to discuss. The primary goal of present review was to analyze the literature on the problem of anastomotic leakage, determine preoperative risk factors for this complication. Data concerning patients’ general condition, main disease and comorbidities, as well as preoperative preparation of gastrointestinal tract were evaluated. The most frequent preoperative risk factors for leakage revealed are male sex, smoking and alcohol intake, preoperative anemia and hypoproteinemia, body mass index, high age, preoperative chemical therapy and radiotherapy, omitting mechanical bowel preparation and oral antibiotic therapy.

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Section: хирургическая гастроэнтерология Surgical Gastroenterologymentioning

confidence: 77%

Section: хирургическая гастроэнтерология Surgical Gastroenterologymentioning

confidence: 99%

Section: хирургическая гастроэнтерология Surgical Gastroenterologymentioning

confidence: 99%

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Preoperative Risk Factors for Anastomotic Leaks in Colorectal Surgery

Исмаилова¹,

Агаев²,

Israfilova³

2022

Хирургия. Восточная Европа

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“…One of the most common complications is anastomotic leak, which leads to high morbidity and mortality rates. Therefore, anastomotic leak has been one of the most investigated topics in colorectal surgery 11 , 24 . In the literature, there are experimental studies on anastomotic healing which involve methods such as reducing the number of sutures, dexpanthenol, coenzyme Q10, krill oil, and fish oil 3 , 6 , 9 , 17 .…”

Section: Introductionmentioning

confidence: 99%

Different Surgical Methods in Colon Anastomosis: Experimental Study

Çantay

Aydin

Özaydin

et al. 2022

ABCD, arq. bras. cir. dig.

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- BACKGROUND: Although many methods have been defined for colonic anastomosis, anastomotic leak still remains important for sepsis control and successful healing. AIM: The purpose of this study was to compare the effects of conventional suture, polyglactin 910 mesh, and omental flap coverage on healing and anastomotic leak in experimental colonic anastomosis in rats. METHOD: This study was conducted on 18 Wistar rats and the animals were divided into three groups as follows: Group 1: primary suture group; Group 2: primary suture plus polyglactin 910 mesh group; and Group 3: primary suture plus omental flap coverage group. Groups were compared in terms of anastomotic bursting pressure, inflammation, fibroblastic activity, neovascularization, and collagen amount. RESULTS: There was a statistically significant difference in anastomotic bursting pressure between Groups 1 and 2 and between Groups 1 and 3 (p=0.004, p<0.05). There was a significant difference in fibroblastic activity between Groups 1 and 3 (p=0.011, p<0.05) and between Groups 2 and 3 (p=0.030, p<0.05). There was a significant difference in neovascularization and collagen between Groups 1 and 2 and between Groups 1 and 3 (p<0.05). CONCLUSION: This experimental study found that polyglactin 910 mesh and omental flap coverage for colocolic anastomoses improved the physical strength and healing of the anastomosis compared to conventional hand-stitched anastomoses. The polyglactin may be a safe alternative to 910 mesh in cases where the omental flap coverage cannot be used in the colonic anastomosis.

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“…Additionally, Benacerraf et al [ 5 , 6 ] pointed out that the anastomosis leakage risk rate was almost 100% in cases where perianastomotic tissue oxygen pressure levels dropped below 20 mm-Hg, and the rate of anastomotic leakage decreased with increases in oxygen pressure [ 5 , 6 ]. Therefore, anastomotic leaks after intestinal, colonic, and colorectal anastomosis surgery continue to be an important problem today [ 7 , 8 ]. Although the number of studies aimed at preventing or reducing ischemic damage in colon anastomosis has increased in recent years, as far as we know, no research has been found in the literature investigating the effects of dexpanthenol or coenzyme Q10 (CoQ10) administration on the healing of ischemic colonic anastomosis [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Healing of Ischemic Colon Anastomosis in Rats Could Be Provided by Administering Dexpanthenol or Coenzyme Q10

Pehlivanli

Aydın

Karaca

et al. 2018

JCM

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Background: In this study, the effectiveness of dexpanthenol and coenzyme Q10 (CoQ10) on the healing of ischemic colon anastomosis was investigated. Methods: Forty eight male Wistar Albino rats were divided into four equal groups (Sham-S, Sham-I, DXP, Q10). Following full layer colon resection, single layer colon anastomosis, without creating ischemia, was performed on the Sham-S group. The same experimental model was performed on remaining groups after ischemia was created. Intraperitoneal dexpanthenol and CoQ10 was administered to the DXP and Q10 groups once a day for three days. Ten days later, all colon anastomoses were investigated histopathologically and biochemically, as well as their burst pressure values, in all sacrificed rats. Results: The highest burst pressure value was observed in the Sham-S group, decreasing from high to low in the DXP, Q10, and Sham-I groups, respectively (p = 0.008). Furthermore, tissue hydroxyproline (p = 0.001) level values were significantly different among the groups. Additionally, histopathological analysis revealed a significant difference among groups regarding reepithelization (p = 0.027) and polymorphonuclear leukocyte density (p = 0.022). Conclusions: This preliminary study has shown that ischemia-reperfusion injury may impair the healing of colon anastomosis and it has been concluded that dexpanthenol and CoQ10 may have positive effects on the healing of ischemic colon anastomosis in rat, although re-epithelization may be adversely affected using CoQ10.

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Comparison of effects of the tacrolimus and cyclosporine A on the colon anastomosis recovery of rats

Cited by 7 publications

References 27 publications

Preoperative Risk Factors for Anastomotic Leaks in Colorectal Surgery

Preoperative Risk Factors for Anastomotic Leaks in Colorectal Surgery

Different Surgical Methods in Colon Anastomosis: Experimental Study

Healing of Ischemic Colon Anastomosis in Rats Could Be Provided by Administering Dexpanthenol or Coenzyme Q10

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