Comparison of Ertapenem and Ceftriaxone Therapy for Acute Pyelonephritis and Other Complicated Urinary Tract Infections in Korean Adults: A Randomized, Double-Blind, Multicenter Trial

Park, Dae Won; Peck, Kyong Ran; Chung, Moon Hyun; Lee, Jin Seo; Park, Yoon Soo; Kim, Hyo Youl; Lee, Mi Suk; Kim, Jung Yeon; Yeom, Joon‐Sup

doi:10.3346/jkms.2012.27.5.476

Cited by 21 publications

(17 citation statements)

References 25 publications

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“…A clinical cure was defined as defervescence and the absence of UTI symptoms or signs at the 4 to 14 day follow-up visit after the EOT. Clinical failure was defined as the persistence or recurrence of pretherapy urinary tract signs and symptoms within the 4 to 14 day follow-up after completion of antimicrobial therapy [ 13 , 14 ].…”

Section: Methodsmentioning

confidence: 99%

A comparison of the clinical characteristics of elderly and non-elderly women with community-onset, non-obstructive acute pyelonephritis

Chang

Kim

Noh

et al. 2015

Korean J Intern Med

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Background/AimsAcute pyelonephritis (APN) is the most common cause of community-onset bacteremia in hospitalized elderly patients. The objectives of this study were to investigate the differences in the clinical and microbiological data of hospitalized elderly and non-elderly women with community-onset APN.MethodsWomen with community-onset APN as a discharge diagnosis were identified from January 2004 to December 2013 using an electronic medical records system. We compared the clinical and microbiologic data in elderly and non-elderly women with community-onset APN due to Enterobacteriaceae.ResultsOf the 1,134 women with community-onset APN caused by Enterobacteriaceae, 443 were elderly and 691 were non-elderly women. The elderly group had a lower frequency of upper and lower urinary tract symptoms/signs than the non-elderly. The incidence of bacteremia, extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, patients with a C-reactive protein (CRP) level ≥ 15 mg/dL, and patients with a leukocyte count ≥ 15,000/mm3 in the blood, were significantly higher in the elderly group than in the non-elderly group. The proportion of patients requiring hospitalization for 10 days or more was significantly higher in the elderly group compared to the non-elderly group (51.5% vs. 26.2%, p < 0.001). The clinical cure rates at 4 to 14 days after the end of therapy were 98.3% (338/344) and 97.4% (519/533) in the elderly and non-elderly groups, respectively (p = 0.393).ConclusionsElderly women with APN exhibit higher serum CRP levels, a higher frequency of bacteremia, a higher proportion of ESBL-producing uropathogens, and require a longer hospitalization than non-elderly women, although these patients may not complain of typical urinary symptoms.

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Section: Methodsmentioning

confidence: 99%

A comparison of the clinical characteristics of elderly and non-elderly women with community-onset, non-obstructive acute pyelonephritis

Chang

Kim

Noh

et al. 2015

Korean J Intern Med

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“…Studies dealing with the consequences of widespread administration of enrofloxacin have demonstrated an increase in the proportion of resistant bacteria isolated from dogs with urinary tract infections (Cooke 2002;Cohn 2003). Ceftriaxone therapy has been documented to be efficacious in the management of human complicated or uncomplicated urinary tract infections (Iravani and Richard 1985;Park et al 2012;Lin et al 2016). However, pharmacological studies investigating the efficacy of ceftriaxone in veterinary medicine are limited (Soback and Ziv 1988;Ringger et al 1996;Ringger et al 1998;Rebuelto et al 2002).…”

mentioning

confidence: 99%

Efficacy of single-dose ceftriaxone versus multiple-dose enrofloxacin in dogs with uncomplicated lower urinary tract infection: a randomised clinical trial

Çolakoğlu¹,

Haydardedeoğlu²,

Alihosseini³

et al. 2017

Vet. Med. - Czech

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Dogs with uncomplicated lower urinary tract infection (LUTI) are usually treated with appropriate antibiotics for 10−14 days. In humans, a single dose of ceftriaxone is employed in the treatment of uncomplicated LUTI. The purpose of the current study was to compare the efficacy of a single dose of ceftriaxone with multiple dose (14 days) enrofloxacin administration in dogs with uncomplicated LUTI. Forty-seven non-pregnant clientowned dogs with LUTI signs were enrolled in this prospective, controlled, randomised, blinded clinical trial. The inclusion criteria were the presence of at least one type of bacteria greater than or equal to 1000 CFU/ml in each urine sample. Dogs were assigned randomly to Group ENR (n = 23) enrofloxacin treatment (5 mg/kg, s.c., s.i.d., for 14 days) and Group CEF (n = 20) ceftriaxone treatment (25 mg/kg, i.v., once). The time needed for disappearance of clinical signs ranged from 4−9 days and 1−5 days for Group ENR and Group CEF, respectively. Clinical signs significantly improved earlier in Group CEF than in Group ENR (P < 0.0001). Urine culture with less than or equal to 1000 CFU/ml was achieved on Days 17−21 after the first day of treatment in all dogs. Although a single dose of ceftriaxone can be considered as an alternative treatment to alleviate the signs of uncomplicated LUTI in dogs, its status as drug of last resort is a limiting factor for its extensive use in clinical practice.

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“…Clinical failure at the 4-14-day follow-up was defined as the continuation or recurrence of UTI signs and symptoms within 4-14 days of follow-up after the EOT. 14 15 …”

Section: Methodsmentioning

confidence: 99%

Comparison of Second- and Third-Generation Cephalosporin as Initial Therapy for Women with Community-Onset Uncomplicated Acute Pyelonephritis

2015

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PurposeThis study examined the clinical effectiveness of parenteral cefuroxime and cefotaxime as empirical antibiotics for treating hospitalized women with uncomplicated acute pyelonephritis (APN).Materials and MethodsThis study was based on the clinical and microbiologic data of 255 hospitalized women with APN. Of these 255 women, 144 patients received cefuroxime and 111 received cefotaxime.ResultsThere were no marked differences in the demographic features, clinical characteristics, and treatment duration between the populations of the cefuroxime and cefotaxime groups. The rates of defervescence showed no significant differences in the two groups at 48, 72, 96, and 120 hours. The clinical cure rates observed at the follow-up visit 4 to 14 days after the completion of antimicrobial therapy were not statistically different between the cefuroxime and cefotaxime groups [94.9% (129 of 136) versus 98.0% (100 of 102), respectively; p=0.307], and the microbiological cure rates were also not significantly different [88.3% (91 of 103) versus 95.0% (76 of 80), respectively; p=0.186]. The median hospitalization periods in the cefuroxime and cefotaxime groups were 7 (6-8) and 7 (6-8) days (p=0.157), respectively. Microbiological success rates after 72-96 hours of initial antimicrobial therapy were also not statistically different in the cefuroxime and cefotaxime groups, 89.4% (110 of 123) versus 94.9% (93 of 98; p=0.140).ConclusionCefuroxime, a second-generation cephalosporin, is an appropriate antibiotic option for the initial treatment of uncomplicated APN and its efficacy does not differ from cefotaxime, a third-generation cephalosporin, in the initial parenteral therapy for community-onset APN.

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Comparison of Ertapenem and Ceftriaxone Therapy for Acute Pyelonephritis and Other Complicated Urinary Tract Infections in Korean Adults: A Randomized, Double-Blind, Multicenter Trial

Cited by 21 publications

References 25 publications

A comparison of the clinical characteristics of elderly and non-elderly women with community-onset, non-obstructive acute pyelonephritis

A comparison of the clinical characteristics of elderly and non-elderly women with community-onset, non-obstructive acute pyelonephritis

Efficacy of single-dose ceftriaxone versus multiple-dose enrofloxacin in dogs with uncomplicated lower urinary tract infection: a randomised clinical trial

Comparison of Second- and Third-Generation Cephalosporin as Initial Therapy for Women with Community-Onset Uncomplicated Acute Pyelonephritis

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