Comparison of experimental hypercholesterolemia and atherosclerosis in Göttingen Mini-pigs and Swedish domestic swine

Choroidal Vessel Wall: Hypercholesterolaemia-Induced Dysfunction and Potential Role of Statins

“…The minipig, smaller than the domestic swine, has served as a model of hypercholesterolaemia for more than two decades now. In 1986, Jacobsson reported that the Göttingen strain had more susceptibility to alimentary hypercholesterolaemia and experimental atherosclerosis than did domestic swine of the Swedish Landrace [106]. Clawn [107], Yucatan, Sinclair, and Handford are among other general minipigs used for experimental use [107][108][109].…”

Measurements of Insulin Secretory Capacity and Glucose Tolerance to Predict Pancreatic β-Cell Mass In Vivo in the Nicotinamide/Streptozotocin Göttingen Minipig, a Model of Moderate Insulin Deficiency and Diabetes

“…The Gö ttingen minipig offers many advantages in this context because of its well-described biology with respect to glucose and lipid metabolism both in normal animals (32)(33)(34)(35) and after induction of diabetes (35,36) or challenge with high-fat diets (32,34,37,38). Furthermore, these animals can be trained to allow experiments to be performed in conscious unstressed animals.…”

Valine Pyrrolidide Preserves Intact Glucose‐Dependent Insulinotropic Peptide and Improves Abnormal Glucose Tolerance in Minipigs With Reduced β‐Cell Mass

“…The Göttingen minipig was chosen because its size makes it possible to obtain a relatively large number of blood samples, thus making this species useful in the study of GLP-1 and GIP metabolism. Furthermore, the pig shares many anatomical and physiological similarities of digestion and metabolism with the human [6,42,64] and the Göttingen minipig has been characterized in detail, both with respect to general characteristics such as clinical chemistry and hematology [15,19,29] and, more specifically, with respect to glucose and lipid metabolism both in normal animals [28,35,36,37] and after induction of diabetes [31,37] or challenge with high-fat diets [26][27][28]36].…”