Comparison of fractional exhaled nitric oxide in asthmatics with and without allergic rhinitis

Galiniak, Sabina; Rachel, Marta

doi:10.1080/1354750x.2020.1871410

Cited by 4 publications

(6 citation statements)

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“…The effect of age on FeNO is inconclusive. Some studies indicate that age affects FeNO, and others that age is an independent factor [ 8 , 9 , 21 , 22 ]. However, the influence of age on FeNO might be associated with geometrical factors such as the total area of airway mucosa which produces NO [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…FeNO is used as a non-invasive marker for determining the degree of inflammation and efficiency of corticosteroid treatment. Elevated FeNO was observed in children and adults with asthma, allergic rhinitis, combined asthma, and allergic rhinitis as well as a chronic obstructive pulmonary disease [ 8 , 9 , 10 ]. Due to the growing number of reports on the influence of many factors on FeNO, FeNO is beginning to be considered an invaluable tool for the detection of asthma in patients with AD.…”

Section: Introductionmentioning

confidence: 99%

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Fractional Exhaled Nitric Oxide in Teenagers and Adults with Atopic Dermatitis

Galiniak

Rachel

2022

ARM

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Fractional exhaled nitric oxide (FeNO) is a non-invasive biomarker of eosinophilic airway inflammation and therapeutic response to corticosteroid treatment of respiratory diseases. Atopic dermatitis (AD), one of the most common allergic conditions of the skin, is a factor influencing the increase of FeNO. The main aim of this study was to determine differences between levels of FeNO in patients with AD and healthy controls as measured by an electrochemical analyzer. In total, 54 teenagers and adults with AD were recruited and compared with 34 healthy volunteers. The measurements of FeNO were taken using the Hyp’Air FeNO in participants. FeNO was statistically significantly higher in patients with AD than in healthy controls (60.5 ± 35.1 vs. 14.8 ± 5.1 ppb, p < 0.001). We found a strong positive significant correlation between FeNO and the number of positive skin prick tests among AD patients (R = 0.754, p < 0.001). There was no correlation between FeNO and duration of disease as well as SCORAD index among patients. Moreover, we also found no FeNO difference between the mild and moderate forms of AD. The presence of AD and the increasing number of positive skin prick tests increase FeNO, so the results of this measurement should be interpreted with caution in patients with respiratory diseases suffering from AD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fractional Exhaled Nitric Oxide in Teenagers and Adults with Atopic Dermatitis

Galiniak

Rachel

2022

ARM

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“…Based on the results of research FeNO measurements are suggested to be applicable in the assessment of the severity of the inflammatory process in the lower pathways respiratory tract in patients with AR, which may allow for selecting patients who are particularly susceptible to getting asthma in the future. Additionally, they can be useful in the diagnosis of rhinitis, pointing to its allergic nature, and are associated with time duration and course of the AR [54].…”

Section: Allergic Rhinitis (Ar)mentioning

confidence: 99%

An Evidence-Based Review of Application Devices for Nitric Oxide Concentration Determination from Exhaled Air in the Diagnosis of Inflammation and Treatment Monitoring

et al. 2022

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The measurement of nitric oxide (NO) in exhaled air is used in diagnostics and monitoring the pathologies not only in the respiratory system but also in the oral cavity. It has shown a huge increase in its level in asthma and diseases of the oral cavity. It seems reasonable to undertake research on the impact of inflammation on the level of NO in exhaled air. The aim of the study is to make an evidence-based review of the application of NO levels in exhaled air in the diagnosis of inflammation and treatment monitoring on the basis of selected measuring devices. Methods and Results: This paper presents an example of the application of NO measurement in exhaled air in individual human systems. Selected measuring devices, their non-invasiveness, and their advantages are described. Discussion: The usefulness of this diagnostic method in pathologies of the oral cavity was noted. Conclusions: Measuring the level of NO in exhaled air seems to be a useful diagnostic method.

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“…Recent studies show NO production in mast cells in response to different infections [9][10][11]. The exhaled NO (eNO) level is a marker of NO production in the respiratory tract [12][13][14]. Its level correlates with the intensity of airway inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…As it is present in the respiratory tract epithelium and cells that take part in inflammation, NO is used as a marker of type 2 airway inflammation [12,15]. The increased level of eNO -measured as fractional exhaled NO (FeNO) or alveolar concentration of NO (CaNO) was proven in patients suffering from asthma, rhinitis as well as bronchiectasis and interstitial lung disease [12][13][14]16,17]. Additionally, it was proven to be raised in patients with scleroderma and sarcoidosis, although the usefulness of FeNO and CaNO measurements in those conditions remains inconclusive [18,19].…”

Section: Introductionmentioning

confidence: 99%

Exhaled Nitric Oxide Level in Pharynx Angioedema

Moos

Zając

Brzoza

2022

JCM

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Airway inflammation is related to increased nitric oxide production. It can be assessed noninvasively with exhaled nitric oxide measurement. As airway inflammation was supposed to be present in chronic urticaria and angioedema patients we hypothesized increased exhaled nitric oxide in this group. Twenty-six symptomatic chronic urticaria patients with an acute episode of pharynx angioedema (17 women and 9 men, median age 35) were included in the study group. None of the patients reported a history of asthma, allergic rhinitis or cigarette smoking. The control group consisted of 29 non-smoking healthy subjects (19 women and 10 men, median age 22) without any history of atopy. Exhaled nitric oxide measurement was performed in all subjects. Exhaled nitric oxide levels in the angioedema group did not differ statistically significantly from those detected in healthy subjects (15.5 ppb and 17.0 ppb respectively). Our results indicate the lack of airway inflammation in chronic urticaria patients with pharynx angioedema.

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Comparison of fractional exhaled nitric oxide in asthmatics with and without allergic rhinitis

Cited by 4 publications

References 57 publications

Fractional Exhaled Nitric Oxide in Teenagers and Adults with Atopic Dermatitis

Fractional Exhaled Nitric Oxide in Teenagers and Adults with Atopic Dermatitis

An Evidence-Based Review of Application Devices for Nitric Oxide Concentration Determination from Exhaled Air in the Diagnosis of Inflammation and Treatment Monitoring

Exhaled Nitric Oxide Level in Pharynx Angioedema

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