“…The detection is based on the intrinsic elemental composition of labeling reagents (atomic spectrometry), thus largely alleviate the worry about their synthesis and stability. However, due to either the lack of multiplex potential or low sensitivity, the detection by atomic spectrometry including atomic absorption spectrometry (AAS), atomic fluorescence spectrometry (AFS), and atomic emission spectrometry (AES) are useful but not attractive (Mariet et al, ; Remy et al, ; Wang et al, ; Wu et al, ; Liang et al, ; Liu et al, ; Tung et al, ). Only after the distinct merits of multiplex potential and high sensitivity were brought by ICPMS, the combination of atomic spectrometry and element‐tagged immunoassay opened up a new avenue for quantitative bioanalysis.…”