Comparison of Heart Transplantation Patients with Ischemic and Idiopathic Dilated Cardiomyopathy

Güngör, Hasan; Oğuz, Enis; Ayık, Mehmet Fatih; Ertugay, Serkan; Engin, Çağatay; Yağdı, Tahir; Nalbantgil, Sanem; Zoghi, Mehdi; Özbaran, Mustafa

doi:10.1016/j.transproceed.2011.09.073

Cited by 10 publications

(12 citation statements)

References 15 publications

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“…27 Thus, even if the underlying severity and etiology of the heart failure differs by gender, as seen in our findings, the question remains as to why more men are transplanted than women.…”

Section: Discussionmentioning

confidence: 69%

Clinical and gender differences in heart transplant recipients in the NEW HEART study

Hickey

Doering

Chen

et al. 2016

European Journal of Cardiovascular Nursing

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Background Little attention has focused on gender differences in cardiac comorbidities and outcomes in patients undergoing orthotropic heart transplant. Objective The objective of this study was to investigate gender differences at baseline and during follow-up among heart transplant patients. Methods An observational cohort within the NEW HEART study was evaluated to determine gender differences in relation to age, coexisting cardiac comorbidities, and outcomes. Differences were assessed by t-test, Fisher’s exact test, and logistic regression analysis. Results Male transplant recipients (n = 238) were significantly older than female recipients (n = 92), with a greater percentage over 60 years of age (45% vs. 24%, p = 0.0006). Males were more likely to have hypertension (63% vs. 49%, p = 0.034), dyslipidemia (62% vs. 45%, p = 0.006), a history of smoking (52% vs. 35%, p = 0.009), and diabetes (42% vs. 21%, p = 0.0002). Analysis of endomyocardial biopsies obtained during the 1-year follow-up period demonstrated that women averaged more episodes of acute rejection than men (3.9 vs. 3.0, p = 0.009). While most episodes of rejection were mild, women were more likely than men to have episodes of moderate or severe rejection (14% vs. 5%, p = 0.012) and to be hospitalized for acute rejection (15% vs. 6%, p = 0.013). There were no significant differences in mortality. Conclusions Men were more likely than women to be older and to have diabetes, dyslipidemia, hypertension, and a history of smoking. Women were more likely to experience moderate or severe allograft rejection and to be hospitalized for acute rejection. Future investigation of the reasons for these gender differences is warranted and may improve clinical care of women undergoing cardiac transplantation.

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“…27 Thus, even if the underlying severity and etiology of the heart failure differs by gender, as seen in our findings, the question remains as to why more men are transplanted than women.…”

Section: Discussionmentioning

confidence: 69%

Clinical and gender differences in heart transplant recipients in the NEW HEART study

Hickey

Doering

Chen

et al. 2016

European Journal of Cardiovascular Nursing

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“…Most of the cohort studies (27 studies, 82%) were deemed moderate quality due to their retrospective study design (96%) with uncertain outcome ascertainment. The remaining six (18%) studies were deemed low quality due to additional issues related to study attrition and uncertain patient selection …”

Section: Resultsmentioning

confidence: 99%

“…Table 1 shows the characteristics of the 33 cohorts reporting on the Most of the cohort studies (27 studies, 82%) were deemed moderate quality due to their retrospective study design (96%) with uncertain outcome ascertainment. The remaining six (18%) studies were deemed low quality due to additional issues related to study attrition [9][10][11][12][13][14] and uncertain patient selection. [11][12][13][14] Twenty-two studies evaluated the risk of SCD in all patients undergoing transplantation, 6,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] The confidence in this evidence was deemed to be low based on the presence of risk of bias at the study level related to uncertainty around outcome ascertainment and publication bias ( Figure S1), which could have led to SCD risk overestimation.…”

Section: Data Synthesis and Statistical Analysismentioning

confidence: 99%

Incidence and predictors of sudden cardiac death after heart transplantation: A systematic review and meta‐analysis

Alba

Foroutan

Hing

et al. 2018

Clinical Transplantation

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“…25,26 Other researchers have demonstrated that survival and morality rates do not differ between OHT patients with ischemic cardiomyopathy as compared to those with a dilated cardiomyopathy. 27 Thus, even if the underlying severity and etiology of the heart failure differs by gender, as seen in our findings, the question remains as to why more men are transplanted than women.…”

Section: Discussionmentioning

confidence: 69%

Clinical and Gender Differences in Heart Transplant Recipients in the New Heart Study

Hickey¹,

Doering²,

Chen³

et al. 2015

The Journal of Heart and Lung Transplantation

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Comparison of Heart Transplantation Patients with Ischemic and Idiopathic Dilated Cardiomyopathy

Cited by 10 publications

References 15 publications

Clinical and gender differences in heart transplant recipients in the NEW HEART study

Clinical and gender differences in heart transplant recipients in the NEW HEART study

Incidence and predictors of sudden cardiac death after heart transplantation: A systematic review and meta‐analysis

Clinical and Gender Differences in Heart Transplant Recipients in the New Heart Study

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