Comparison of IL-17 Production by Helper T Cells among Atopic and Nonatopic Asthmatics and Control Subjects

Hashimoto, Tomomi; Akiyama, Kazuo; Kimura, Noriaki; Mori, Akio

doi:10.1159/000085432

Cited by 94 publications

(73 citation statements)

References 28 publications

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“…21,22 Th17 cells are the newly recognized CD4 þ T-cell subset, which mainly produces cytokines, including IL-17A, IL-17F, and IL-22, and is involved in a wide range of autoimmune diseases. [11][12][13] The level of IL-17 was found to be correlated with both activity and severity of various autoimmune diseases. Studies conducted on experimental mice model of DE have found that the level of IL-17 was significantly increased on the ocular surface and in tears.…”

Section: Discussionmentioning

confidence: 99%

“…Both IL-17 and IL-22 are the effective cytokines of Th17 cells, the levels of which, in tears, may represent the immune response of Th17 cells during the pathogenesis of DED. [11][12][13] In this study, we evaluated the levels of IL-17 and IL-22 in tears of patients with Sjögren's or non-Sjögren's syndrome DED. In addition, the correlation between disease severity and IL-17 as well as IL-22 levels in patients was also analyzed.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Th17-associated cytokines in tears of patients with dry eye syndrome

Tan

Sun

Liu³

et al. 2014

Eye

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Purpose To determine the levels of Th17-associated cytokines, particularly interleukin (IL)-17 and IL-22 in tears of patients with dry eye syndrome. Methods Tear samples were collected from 20 healthy volunteers, 20 dry eye (DE) patients with non-Sjö gren's syndrome (NSSDE) and 20 DE patients with Sjö gren's syndrome (SSDE). Symptom questionnaire was self-administered and multiple dry eye disease (DED)-related clinical tests were performed. The levels of IL-17 and IL-22 in tears were measured by enzyme-linked immunosorbent assay. Results The levels of IL-17 and IL-22 were significantly increased in tears of DE patients compared with those of controls and also higher in SSDE patients compared with those of NSSDE patients (Po0.05). Moreover, the levels of IL-17 and IL-22 were positively correlated with questionnaire score and keratopathy score but negatively correlated with tear film break-up time and Schirmer I test in both NSSDE and SSDE patients (Po0.05). Conclusions The levels of IL-17 and IL-22 in tears were significantly increased in DE patients, which were associated with the disease severity. Therefore, Th17 cellassociated cytokines, particularly IL-17 and IL-22, may have important roles in the immunopathogenesis of the DED.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of Th17-associated cytokines in tears of patients with dry eye syndrome

Tan

Sun

Liu³

et al. 2014

Eye

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“…It remains to be evaluated whether Th17 or Tc17 cells in the airways of patients with asthma share characteristics with the corresponding blood cells [12,13,48,[51][52][53][54][55][56][57]. Moreover, the documentation of expression for IL-17A in invariant natural killer T-cells and in mucosal-associated invariant T-cells from human subjects is intriguing but further study is needed given that there are no published studies addressing these cell types in the airways of patients with asthma [11,13,42,44,48,[50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66].…”

Section: Multiple Cellular Sourcesmentioning

confidence: 99%

“…HASHIMOTO et al [60] demonstrated that isolated mononuclear cells harvested from the blood of patients with allergic asthma produce IL-17A protein in response to stimulation with anti-CD3 plus anti-CD28 antibodies and house dust mite extract. Examining peripheral blood mononuclear cells from patients with allergic asthma, ZHAO et al [64] subsequently showed that there is a subset of CD3-positive and CD8-negative cells with immunoreactivity for IL-17A, arguing that it is the Th17 and not the Tc17 population that is involved in asthma.…”

Section: Sources In the Bloodmentioning

confidence: 99%

Interleukin-17 cytokine signalling in patients with asthma

Lindén

Dahlén

2014

Eur Respir J

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Asthma remains a global health problem and, therefore, more effective pharmacotherapy is needed. This is particularly true for chronic and severe asthma. In these clinical phenotypes, chronic inflammation involving neutrophils is likely to play a pathogenic role, making it interesting to target cytokine signalling involved in the accumulation of neutrophils. Therefore, it is of interest that the archetype T-helper 17 cell cytokine interleukin (IL)-17A, perhaps also IL-17F, controls neutrophil accumulation, mucus secretion, macrophage mobilisation and smooth muscle reactivity in various experimental airway models. However, much less is known about the involvement of signalling via IL-17 cytokines in humans with asthma. Existing evidence suggests that these cytokines are released from several types of immune cells in asthma and, for IL-17A, there is a local increase associated with disease severity, with the mobilisation of neutrophils and smooth muscle cells locally in the airways. Even though the causative role of IL-17 cytokines remains unclear, there is potential for clinical utility in targeting IL-17A specifically in patients with moderate-to-severe asthma and high reversibility. There is a need for new and well-powered clinical investigations of signalling via IL-17 cytokines in this clinical phenotype. @ERSpublications There is potential utility for drugs targeting IL-17 cytokine signalling in a sub-group of patients with asthma

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“…Increased levels of IL-17 have been found in bronchoalveolar lavage fluid (BALF), sputum, and blood from patients with allergic asthma (15)(16)(17)(18)(19)(20). In mouse models of allergic asthma, systemic blockage of IL-17 inhibited the allergen-induced accumulation of neutrophils in the airway and AHR (20)(21)(22), suggesting that IL-17 plays an important role during the pathophysiological process of allergic asthma.…”

mentioning

confidence: 99%

Complement C3a-Induced IL-17 Plays a Critical Role in an IgE-Mediated Late-Phase Asthmatic Response and Airway Hyperresponsiveness via Neutrophilic Inflammation in Mice

Mizutani

Goshima

Nabe

et al. 2012

The Journal of Immunology

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Allergen-specific IgE plays an essential role in the pathogenesis of allergic asthma. Although there has been increasing evidence suggesting the involvement of IL-17 in the disease, the relationship between IL-17 and IgE-mediated asthmatic responses has not yet been defined. In this study, we attempted to elucidate the contribution of IL-17 to an IgE-mediated late-phase asthmatic response and airway hyperresponsiveness (AHR). BALB/c mice passively sensitized with an OVA-specific IgE mAb were challenged with OVA intratracheally four times. The fourth challenge caused a late-phase increase in airway resistance associated with elevated levels of IL-17+CD4+ cells in the lungs. Multiple treatments with a C3a receptor antagonist or anti-C3a mAb during the challenges inhibited the increase in IL-17+CD4+ cells. Meanwhile, a single treatment with the antagonist or the mAb at the fourth challenge suppressed the late-phase increase in airway resistance, AHR, and infiltration by neutrophils in bronchoalveolar lavage fluid. Because IL-17 production in the lungs was significantly repressed by both treatments, the effect of an anti–IL-17 mAb was examined. The late-phase increase in airway resistance, AHR, and infiltration by neutrophils in bronchoalveolar lavage fluid was inhibited. Furthermore, an anti–Gr-1 mAb had a similar effect. Collectively, we found that IgE mediated the increase of IL-17+CD4+ cells in the lungs caused by repeated Ag challenges via C3a. The mechanisms leading to the IgE-mediated late-phase asthmatic response and AHR are closely associated with neutrophilic inflammation through the production of IL-17 induced by C3a.

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Comparison of IL-17 Production by Helper T Cells among Atopic and Nonatopic Asthmatics and Control Subjects

Cited by 94 publications

References 28 publications

Analysis of Th17-associated cytokines in tears of patients with dry eye syndrome

Analysis of Th17-associated cytokines in tears of patients with dry eye syndrome

Interleukin-17 cytokine signalling in patients with asthma

Complement C3a-Induced IL-17 Plays a Critical Role in an IgE-Mediated Late-Phase Asthmatic Response and Airway Hyperresponsiveness via Neutrophilic Inflammation in Mice

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