Comparison of local anesthetic-cyclodextrin non-covalent complexes using capillary electrophoresis and electrospray ionization mass spectrometry

Alnouti, Yazen; Bartlett, Michael G.

doi:10.1016/s1044-0305(02)00395-1

Cited by 15 publications

(9 citation statements)

References 24 publications

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“…Non-covalent complexes between three different cyclodextrins (CD) and six local anaesthetics were studied using capillary electrophoresis (CE) and electrospray ionisation mass spectrometry (ESI-MS) [101].…”

Section: Capillary Electrophoresismentioning

confidence: 99%

Chiral Aspects of Local Anesthetics

et al. 2020

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Thanks to the progress made in chemical technology (particularly in the methodologies of stereoselective syntheses and analyses) along with regulatory measures, the number of new chiral drugs registered in the form of pure enantiomers has increased over the past decade. In addition, the pharmacological and pharmacokinetic properties of the individual enantiomers of already-introduced racemic drugs are being re-examined. The use of the pure enantiomer of a drug that has been used to date in the form of a racemate is called a “chiral switch”. A re-examination of the properties of the pure enantiomers of racemates has taken place for local anesthetics, which represent a group of drugs which have long been used. Differences in (R) and (S)-enantiomers were found in terms of pharmacodynamic and pharmacokinetic activity as well as in toxicity. Levobupivacaine and robivacaine were introduced into practice as pure (S)-(−)-enantiomers, exhibiting more favorable properties than their (R)-(+)-stereoisomers or racemates. This overview focuses on the influence of chirality on the pharmacological and toxicological activity of local anesthetics as well as on individual HPLC and capillary electrophoresis (CE) methods used for enantioseparation and the pharmacokinetic study of individual local anesthetics with a chiral center.

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Section: Capillary Electrophoresismentioning

confidence: 99%

Chiral Aspects of Local Anesthetics

et al. 2020

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“…Therefore, combining MEPS and CE can provide interesting advantages. Local anesthetics and their metabolites have so far been determined by CZE [23][24][25][26][27][28], EKC [12,[29][30][31][32] and NACE [26,[33][34][35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Direct automatic determination of free and total anesthetic drugs in human plasma by use of a dual (microdialysis–microextraction by packed sorbent) sample treatment coupled at‐line to NACE–MS

et al. 2009

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This paper reports for the first time the use of microextraction by packed sorbent in combination with CE. The combined system was used to determine anesthetic drugs in human plasma. A microdialysis fiber was coupled on-line to the microextraction unit in order to distinguish between free and total concentrations of drugs. The system was automated by connecting the microextraction unit to a syringe pump and interfacing it to a computer. The ensuing method allows the determination of 10 microg/L concentrations of free drugs and 1 microg/L concentrations of total drugs from only 200 microL of sample with an RSD of less than 9%.

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“…Fax: +81-795-23-5793; E-mail: n.yamane@jclbio.com Abbreviations: ESI-MS, electrospray ionization mass spectrometry; CD, -cyclodextrin; PG, prostaglandin; MALDI-TOFMS, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; Glc-CD, glucosyl-CD; Gal-CD, galactosyl-CD; Man-CD, mannosyl-CD; Mal-CD, maltosyl-CD; MM, molecular mechanics; MO, molecular orbital etry was first reported in 1991. 13) Inclusion complexes of amino acids, [14][15][16][17][18][19] peptides 16,20,21) and drugs [22][23][24][25][26] with CDs have been studied by electrospray ionization (ESI). ESI-MS has been used to detect the ions of intact noncovalent inclusion complexes.…”

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confidence: 99%

“…The capillary electrophoresis migration time shift was utilized in order to prove that the ions of true non-covalent complexes had been detected. 24,26) Srinivasan et al have reported that there was correlation between association constants calculated from differences in migration time shifts and peak height ratios for CDs and their complexes obtained by LC/ESI-MS measurements. The results showed that CD-barbiturate complexation behavior in the gaseous phase was similar to that in the solution phase.…”

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confidence: 99%