Comparison of MAC and the Rate of Rise of Alveolar Concentration of Sevoflurane with Halothane and Isoflurane in the Dog

Kazama, Tomiel; Ikeda, Kazuyuki

doi:10.1097/00000542-198803000-00020

Cited by 193 publications

(116 citation statements)

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“…However, the drug of choice for induction and maintenance of anesthesia is sevoflurane by extrapolating from the data obtained from domestic animals as there are no reports of the use of this drug in Xenarthras. This anesthetic agent was chosen because it has a very low blood-gas solubility coefficient, as described by Kazama;Ikeda (1988), promoting a faster recovery of the patient, as observed at the end of the procedure. Gasparotto et al (2017) observed that the total recovery time is an average of 2.5 ± 0.5 hours after dissociative anesthesia.…”

Section: Discussionmentioning

confidence: 99%

Anesthesia in a giant armadillo (Priodontes maximus) for femoral fracture fixation

Stocco

Gomes

Morgado

et al. 2017

AVB

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An adult female armadillo (Priodontes maximus) weighing 32.4 kg was admitted to the Veterinary Hospital of the Federal University of Mato Grosso (HOVET-UFMT) -Campus Cuiabá. Results of clinical and complementary examinations revealed a complete oblique fracture of the middle third of the femur. As a pre-anesthetic regimen, a combination of ketamine (10 mg/kg) and midazolam (0.2 mg/kg) was administered, and analgesic support with morphine (0.5 mg/kg) and dipyrone (25 mg/kg) was provided. This was followed by induction of anesthesia through a facial mask and its maintenance with sevoflurane diluted in 100% oxygen by means of a calibrated vaporizer. The anesthetic system used was suitable for the weight of the animal; the animal breathed spontaneously. During the procedure, the animal had stable cardiovascular and respiratory parameters, and had a fast and satisfactory recovery.

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Section: Discussionmentioning

confidence: 99%

Anesthesia in a giant armadillo (Priodontes maximus) for femoral fracture fixation

Stocco

Gomes

Morgado

et al. 2017

AVB

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“…Clinically, the lower blood-gas partition coefficient of sevoflurane has been shown in dogs to result in a more rapid increase in alveolar anesthetic concentration during induction and decrease during recovery, as reflected in a faster induction and quicker recovery (Johnson et al, 1998;Kazama and Ikeda, 1988;Mutoh et al, 1995). Sevoflurane has been reported to be an effective inhalation anesthetic in adult cattle with a rapid and smooth recovery (Hikasa et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…The higher the value of blood-gas partition coefficient, the Science Publications AJAVS greater the solubility of an anesthetic in the blood and vice versa, the lower the value, the lower the blood solubility of the anesthetic. The substitution of a fluorine for chlorine in sevoflurane decreases its blood solubility and hence a lower blood-gas partition coefficient which allows a more rapid increase in alveolar anesthetic concentration during induction and a faster decrease during recovery, thus shorter anesthetic induction and recovery times (Johnson et al, 1998;Kazama and Ikeda, 1988;Mutoh et al, 1995;Steffey and Mama, 2007;Stoelting, 1999). In addition, a lower partition coefficient allows for a faster change of the anesthetic depth which greatly increases the safety of anesthesia.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Isoflurane and Sevoflurane Anesthesia in Holstein Calves for Placement of Portal and Jugular Vein Cannulas

Sellers

Lin

Chamorro

et al. 2013

American Journal of Animal and Veterinary Sciences

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Isoflurane and sevoflurane are the two most commonly used inhalation anesthetics in veterinary medicine today. This study compared the anesthetic effects between isoflurane and sevoflurane in 17 calves undergoing surgery for placement of portal and jugular vein cannulas. Using a randomized control trial, calves were assigned to receive sevoflurane or isoflurane. Anesthesia was induced with xylazine and ketamine then maintained with the assigned inhalation anesthetic. Parameters for heart rate, respiratory rate, indirect blood pressures, oxygen hemoglobin saturation and end-tidal carbon dioxide were monitored and recorded during surgery. The anesthetic concentrations of the vaporizers were adjusted according to the calves' responses, e.g., blood pressure, eye position, respiratory and heart rate, to surgical stimulation. Upon discontinuation of the inhalation anesthetic, calves were placed in sternal recumbency and recovery variables including time to extubation, time to first movement, attempts to stand and time to standing were observed and recorded. Statistical analysis was performed using a two-sample t-test on the recorded variables. There were no statistical differences between isoflurane and sevoflurane for any of the parameters recorded during anesthetic maintenance or recovery. The results of this study showed a faster time to first movement and extubation, 3.38±1.85 min and 11.75±3.73 min for sevoflurane compared to 7.56±5.34 min and 15.56±8.69 min for isoflurane, respectively. Attempts to stand were 3.00±2.14 for sevoflurane and 3.22±1.79 for isoflurane. Though the time to standing during recovery was not statistically different between anesthetics, the values did indicate a quicker trend of recovery from sevoflurane. Both inhalation anesthetics produced comparable anesthetic qualities and there were no statistical differences between the parameters recorded during maintenance of anesthesia. On the basis of the reported results, sevoflurane and isoflurane are suitable inhalation anesthetics for use in calves. However, present cost of sevoflurane is a limiting factor for its use in food animals.

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“…Anesthetic concentrations were maintained at 2.0 minimum alveolar concentration (MAC) during animal preparation: 1.8% halothane, 2.8% isoflurane, and 4.8% sevoflurane, and then at 1.0 MAC during the study: 0.9% halothane, 1.4% isoflurane, and 2.4% sevoflurane. [13] Neuromuscular blockade was provided by an initial i.v. dose of 0.6 mg.kg −1 rocuronium bromide and was maintained at 10 μg.kg.min −1 by using a two-channel infusion pump (Anne; Abbott, Abbott Park, Illinois, USA).…”

Section: Anesthetic Procedures and Animals Preparation For Monitoringmentioning

confidence: 99%

Does the Choice of the Halogenated Anesthetic Influence Renal Function during Hemorrhagic Shock and Resuscitation?

et al. 2009

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Introduction. Halogenated anesthetics can cause changes in the variables that modify the cardiac output necessary to maintain renal hemodynamic during hemorrhagic shock and resuscitation. However, halogenated anesthetics seem to protect against renal ischemia-reperfusion injury. In a model of pressure-guided hemorrhagic shock in dogs, we studied the comparative effects of three halogenated anesthetics-halothane, sevoflurane, and isoflurane-at equipotent concentrations on renal responses after resuscitation. Methods. Thirty dogs were anesthetized with 1.0 minimum alveolar anesthetic concentration (MAC) of halothane, sevoflurane, or isoflurane. The dogs were splenectomized and hemorrhaged to hold mean arterial pressure at 40-50 mm Hg over 45 min and then resuscitated with the shed blood volume. Hemodynamic variables were measured at baseline, after 45 min of hemorrhage, and 15 and 60 min after resuscitation. Renal variables were measured at baseline and 15 and 60 min after resuscitation. Results. Hemorrhage induced reductions of mean arterial pressure, filling pressures, and cardiac index (p < 0.05), without significant differences among groups (p > 0.05). After 60 min of shed blood replacement, all groups restored hemodynamic and renal variables to the prehemorrhage levels (p > 0.05), without significant differences among groups (p > 0.05), with the exception of sodium fractional excretion, the values for which were significantly higher in isoflurane group, in relation to the other groups after 15 min of re-transfusion (p < 0.05), and renal vascular resistance, the values for which remain lower than baseline in halothane group (p < 0.05). Conclusions. We conclude that no difference could be detected between choosing equipotent doses of halothane, sevoflurane, or isoflurane in relation to renal variables in dogs submitted to pressure-adjusted hemorrhagic shock and resuscitation.

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Comparison of MAC and the Rate of Rise of Alveolar Concentration of Sevoflurane with Halothane and Isoflurane in the Dog

Cited by 193 publications

References 0 publications

Anesthesia in a giant armadillo (Priodontes maximus) for femoral fracture fixation

Anesthesia in a giant armadillo (Priodontes maximus) for femoral fracture fixation

Comparison of Isoflurane and Sevoflurane Anesthesia in Holstein Calves for Placement of Portal and Jugular Vein Cannulas

Does the Choice of the Halogenated Anesthetic Influence Renal Function during Hemorrhagic Shock and Resuscitation?

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