Comparison of monolithic approaches for enantioselective capillary electrochromatography involving cyclodextrins

Abstract

The access to CD-modified monoliths for enantiomeric separation by CEC can be divided into two main approaches. (i) Silica-based monoliths, prepared by either a sol -gel process or by sintering of silica particles, are modified after fabrication by coating with a CD selector. Alternatively the fusion of CD functionalized silica particle via gluing is feasible. (ii) Rigid or homogeneous organic polymer-based monoliths, prepared by polymerization of organic monomers in the presence of a porogen, are modified with the CD selector either by copolymerization or by physical incorporation into the continuous bed.

The role of cyclodextrins in chiral capillary electrophoresis

“…Some papers have been published using normally packed columns with CD selectors containing particles [78,79], but the more robust silica-based monolith columns have gained more popularity [75].…”

“…The chiral selective CEC uses also CDs as chiral selectors [12,75]. CDs are used as CSPs as well as chiral CBAs.…”

Enantiomeric Separation by Capillary Electrochromatography on a Sulfated Poly β-Cyclodextrin Modified Silica-based Monolith

“…They are widely used in gas chromatography (GC), high performance liquid chromatography (HPLC), capillary electrophoresis (CE), and capillary electrochromatography (CEC), [1][2][3][4][5][6] as chiral additives or chiral stationary phases (CSPs). Among these methods, CEC has the advantages of high efficiency, high selectivity and low sample consumption.…”

Recent accomplishments in the field of enantiomer separation by CEC

“…Also the application of dedicated SOs has been reviewed. Hence, several authors summarised studies employing proteins and peptides for enantioselective CE and CEC [23][24][25], Wistuba et al [26,27] concentrated on CD phases used in CEC and Chen and Hobo [28] published a review on chiral ligand exchange employed in LC, CE and CEC. Furthermore, two review articles on enantiomer separations by nonaqueous CEC (NA-CEC) have been published by Chankvetadze and Blaschke [29] and Lämmerhofer [30], respectively.…”