Comparison of novel xenograft (bovine fetal growth plate) and allograft effects on experimental bone defect healing in rabbit

Bigham, A. S.; Dehghani, S.; Shafiei, Zahra; Torabinezhad, S

doi:10.1007/s00580-009-0819-6

Cited by 3 publications

(6 citation statements)

References 29 publications

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“…Heart rates, respiratory rates, rumen motility and rectal body temperatures, were not significantly different in comparison with base line values in all treatments throughout the time of the study. Similar results were obtained by Bigham and Shafiei (2008); Bigham et al (2009) and DeRossi et al (2012) who did not observe any cardiovascular side effects after spinal injection of MgSO 4 with different combination of analgesia or anesthesia in animals. These findings encourage the epidural use of MgSO 4 in goats.…”

Section: Discussionsupporting

confidence: 88%

“…Prolonged onset of analgesia time was observed after epidural injection of lidocaine-MgSO 4 mixture in comparison to lidocaine alone. Similar result was obtained by Bigham and Shafiei (2008) and Bigham et al (2009) who suggested that lowering the pH to 5.7 by adding MgSO 4 to lidocaine, could alter levels of ionized and nonionized forms of lidocaine and had a decreased non ionized form (cell membrane permeable form) so, the beginning of analgesia was prolonged.…”

Section: Discussionsupporting

confidence: 81%

“…As well as, in this study, the longest duration of epidural analgesia was achieved following administration of a lidocain-MgSO 4 combination in treatment IV (99.80 ± 2.35 min). This result is supported by Bigham and Shafiei (2008); Bigham et al (2009) and Dehghani and Bigham (2009). On the other hand, epidural injection of magnesium sulfate alone induced a short duration of analgesia with more delayed onset of sensory blockade in sheep (DeRossi et al, 2012).…”

Section: Discussionmentioning

confidence: 87%

“…Epidural administration of agents with greater duration of action is proper for procedures requiring long duration of analgesia. These agents include a fentanyl -magnesium combination in rats; lidocain-MgSo4 in sheep and goat and magnesium sulphate added to ketamine in sheep (Karasawa et al, 1998;Bigham and Shafiei, 2008;Bigham et al, 2009 andDeRossi et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Magnesium Sulphate on Lidocaine Epidural Analgesia in Goats

El-Daharawy

Helal

2012

Assiut Veterinary Medical Journal

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Five adult baladi goats were used to evaluate the effect of different doses of magnesium sulphate (MgSo 4 ) that were injected epidurally in combination with lidocaine Hcl 2% on the duration and area of analgesia as well as side effects. Animals were treated as follow: treatment I was injected with lidocaine Hcl 2% (1 ml/7 kg). Treatments II, III and IV were injected with lidocaine Hcl 2% (1 ml/7 kg) in combination with 25, 50 and 100 mg MgSo 4 10%, respectively. Results revealed that onset of analgesia was delayed in treatments II, III and IV (3, 3.5 and 3.5 minute, respectively). Treatment IV produced the longest duration of analgesia (99.80 ± 2.35 min). There was a significant increase in the animal recumbency in treatment I as compared to other treatments. The extent of analgesic area was almost the same in all treatments that extended from perineum to T13. Ataxic effect recorded in different patterns in treated animals. Treatment I had the longest duration of recumbency followed by mild ataxia in treatment II. In other treatments, ataxia was not developed. In conclusion, the combination of 2% lidocaine with 100 mg MgSo 4 10% injected epidurally in goats resulted in prolonged duration of analgesia extending from the perineum to the flank region without ataxia, cardiovascular or respiratory side effects.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

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The Effect of Magnesium Sulphate on Lidocaine Epidural Analgesia in Goats

El-Daharawy

Helal

2012

Assiut Veterinary Medical Journal

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“…The xenografts are usually transplanted as a calcified matrix unit (Shegarfi and Reikeras 2009); however, it is also possible to transplant materials such as demineralized bone matrix (DBM) that have been obtained from the demineralized xenograft bones (Bigham et al 2008). DBM has successfully been practiced in various studies to fill defects, reconstruct cranio-maxillofacial fractures, bridge large bone and high risk defects, and induce bone formation (Bigham et al 2009). It contains type I collagen, noncollagenous proteins, and osteoinductive growth factors but provides little structural support .…”

Section: Introductionmentioning

confidence: 99%

Fish bone versus fish demineralized bone matrix (vertebra) effects on healing of experimental radial defect in rat model

Oryan

Bigham-Sadegh²,

Monazzah

2016

Comp Clin Pathol

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Surgeons conducting bone grafting procedures have been in search of a bone graft substitute to avoid autogenous bone harvesting because of its associated complications. In the present study, the authors used fish bone and fish DBM in healing of a radial bone defect in a rat model. The 16 female Sprague-Dawley rats used in the present study were divided into the following four groups: autograft (positive control), untreated defect (negative control), and fish DBM, and fish bone graft as the experimental groups. Radiographs were taken in the 1st, 35th, and 56th post-operative days. Histopathological and biomechanical evaluations were performed in 56th post-operative day. The radiological, histopathological, and biomechanical evaluations revealed a superior rate of bone formation in the fish bone graft and autograft groups compared to those of the control. This study showed that the fish bone graft is effective in healing of the radial bone defect in rat.

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