Comparison of oxidative stress on <scp>DNA</scp>, protein and lipids in patients with actinic keratosis, Bowen's disease and squamous cell carcinoma

Yoshifuku, Asuka; Fujii, Kazuyasu; Kanekura, Takuro

doi:10.1111/1346-8138.14631

Cited by 9 publications

(9 citation statements)

References 24 publications

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“…As an extremely common type of skin cancer, SCC is derived from keratinocytes and attacks the upper layer of the skin. Excessive UV exposure is a main causative factor for SCC, and UV-induced ROS play a crucial role in carcinogenesis and in the promotion of SCC, while ROS-mediated oxidative stress exacerbates the oxidative damage of DNA, protein, and lipid, further magnifying the progression and invasion of SCC [75, 76]. UV-produced ROS in skin always act as an essential role in inducing p53 mutation.…”

Section: Relationship Between Ros and Skin Cancermentioning

confidence: 99%

Emerging Perspective: Role of Increased ROS and Redox Imbalance in Skin Carcinogenesis

Xian

Lai

Song

et al. 2019

Oxidative Medicine and Cellular Longevity

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Strategies to battle malignant tumors have always been a dynamic research endeavour. Although various vehicles (e.g., chemotherapeutic therapy, radiotherapy, surgical resection, etc.) are used for skin cancer management, they mostly remain unsatisfactory due to the complex mechanism of carcinogenesis. Increasing evidence indicates that redox imbalance and aberrant reactive oxygen species (ROS) are closely implicated in the oncogenesis of skin cancer. When ROS production goes beyond their clearance, excessive or accumulated ROS could disrupt redox balance, induce oxidative stress, and activate the altered ROS signals. These would damage cellular DNA, proteins, and lipids, further leading to gene mutation, cell hyperproliferation, and fatal lesions in cells that contribute to carcinogenesis in the skin. It has been known that ROS-mediated skin carcinogenesis involves multiple ways, including modulating related signaling pathways, changing cell metabolism, and causing the instability of the genome and epigenome. Nevertheless, the exact role of ROS in skin cancer has not been thoroughly elucidated. In spite of ROS inducing skin carcinogenesis, toxic-dose ROS could trigger cell death/apoptosis and, therefore, may be an efficient therapeutic tool to battle skin cancer. Considering the dual role of ROS in the carcinogenesis and treatment of skin cancer, it would be essential to clarify the relationship between ROS and skin cancer. Thus, in this review, we get the related data together to seek the connection between ROS and skin carcinogenesis. Besides, strategies basing on ROS to fight skin cancer are discussed.

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Section: Relationship Between Ros and Skin Cancermentioning

confidence: 99%

Emerging Perspective: Role of Increased ROS and Redox Imbalance in Skin Carcinogenesis

Xian

Lai

Song

et al. 2019

Oxidative Medicine and Cellular Longevity

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“… 22 According to Yoshifuku et al, 8-OHdG expression was significantly increased in Bowen lesions compared to surrounding nonlesional tissue, SCC lesions and healthy controls. 23 The biomarker 8-OHdG has been pivotal for measuring the effect of endogenous oxidative damage to DNA and is a factor involved in the initiation and promotion of carcinogenesis. Therefore, we speculate that the high expression of HSP105 in Bowen disease might be related to DNA damage or marked cell atypia and poor differentiation.…”

Section: Discussionmentioning

confidence: 99%

Expression of Heat Shock Protein 105 in Cutaneous Squamous Cell Carcinoma: Correlation with Clinicopathological Characteristics

Jia¹,

Li²,

Ye³

et al. 2021

CCID

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Background Heat shock proteins (HSPs), a group of heat stress proteins, are characterized by highly conserved properties. Malignant transformation is a cellular stress, and the expression of HSPs may be affected during this process. Heat shock protein 105 (HSP105) is a protective protein that has long been observed in many cancer types, but little attention has been given to cutaneous squamous cell carcinoma (CSCC). As such, the objectives of this study were to observe the expression of HSP105 on CSCC and evaluate its correlation with clinicopathological characteristics. Methods This retrospective study enrolled 60 patients with CSCC. The patients’ clinical data, including sex, age, tumor location, tumor type, and degree of pathological differentiation, were collected. The expression of HSP105 was measured by Western blot and immunohistochemical staining. Results HSP105 expression was decreased in CSCC (HSCORE=0.65 (0.30, 1.98)) compared with normal skin (HSCORE=2.20 (1.50, 2.80)) (P<0.001). These results were consistent with the Western blot analysis. HSP105 immunostaining of Bowen disease (HSCORE=1.28 (1.08, 2.40)) revealed higher expression than in verrucous carcinoma (HSCORE=0.30 (0.23, 0.85)), keratoacanthoma (HSCORE=0.53 (0.29, 0.93)) and acantholytic squamous cell carcinoma (HSCORE=0.53 (0.41, 0.68) (P<0.01)). Poorly differentiated CSCC showed significantly higher expression of HSP105. Conclusion Our study reveals for the first time that the expression of HSP105 is decreased in CSCC. We suggest that the molecular mechanisms underlying the differential expression of HSP deserve a more rigorous future study, the results of which might explain its role in carcinogenesis and its potential as a target for selective tumor therapy.

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“…La expresión de 8-hidroxi 2'-desoxiguanosina en el cáncer Tequio 5 (15), 2022: [31][32][33][34][35][36][37][38][39][40] ISSN: 2594-0546 TEQUIO, mayo-agosto 2022, vol. 5, no.…”

Section: -Hydroxy 2'-deoxyguanosine Expression In Cancerunclassified

La expresión de 8-hidroxi 2’-desoxiguanosina en el cáncer

Sánchez¹,

Cruz²,

Juárez³

et al. 2022

teq

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The production of reactive oxygen species (ROS) takes place in all organisms. ROS regulate the cell cycle and other biological phenomena that make them essential for life. However, when there is a ROS excess and/or the antioxidant system is reduced, oxidative stress is induced. During this process, ROS can attack various biomolecules and generate oxidative damage. The hydroxyl radical is a highly reactive ROS that can react with guanine in deoxyribonucleic acid (DNA), generating the molecule 8-hydroxy-2’-deoxyguanosine (8-OHdG), a marker of oxidative damage to DNA. Some research have shown that cancer patients or mouse models of cancer have elevated levels of 8-OHdG in serum, urine, saliva, and tissues. This literature review summarizes the main findings of 8-OHdG in several types of cancer and shows the evidence for the potential use of 8-OHdG as a biomarker of oxidative DNA damage in cancer.

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Comparison of oxidative stress on DNA, protein and lipids in patients with actinic keratosis, Bowen's disease and squamous cell carcinoma

Cited by 9 publications

References 24 publications

Emerging Perspective: Role of Increased ROS and Redox Imbalance in Skin Carcinogenesis

Emerging Perspective: Role of Increased ROS and Redox Imbalance in Skin Carcinogenesis

Expression of Heat Shock Protein 105 in Cutaneous Squamous Cell Carcinoma: Correlation with Clinicopathological Characteristics

La expresión de 8-hidroxi 2’-desoxiguanosina en el cáncer

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