Comparison of perinatal outcomes following frozen embryo transfer cycles using autologous versus donor oocytes in women 40 to 43 years old: analysis of SART CORS data

Yu, Bo; Vega, Mario; Zaghi, Sahar; Fritz, Rani; Jindal, Sangita; Büyük, Erkan

doi:10.1007/s10815-018-1287-1

Cited by 9 publications

(3 citation statements)

References 16 publications

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“…Previous studies suggested that donor sperm or oocyte embryo transfer is associated with a risk for preeclampsia in frozen cycles (40,41). Furthermore, donor sperm embryo transfer is associated with an increased risk of SGA, and donor oocyte embryo transfer is associated with a higher risk of preterm births and LBW (41)(42)(43)(44)…”

Section: Discussionmentioning

confidence: 99%

Endometrium preparation and perinatal outcomes in women undergoing single-blastocyst transfer in frozen cycles

Zhang

2021

Fertility and Sterility

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Section: Discussionmentioning

confidence: 99%

Endometrium preparation and perinatal outcomes in women undergoing single-blastocyst transfer in frozen cycles

Zhang

2021

Fertility and Sterility

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“…Epidemiological studies have demonstrated that even singleton pregnancies conceived after IVF-ET are more likely to develop prematurity, gestational hypertension, placental abruption, low birth weight and intrauterine growth retardation [6][7][8][9][10]. The risk of adverse outcomes originating from suboptimal placentation in pregnancies after IVF-ET is significantly greater than that in spontaneously conceived pregnancies [33,34].…”

Section: Discussionmentioning

confidence: 99%

“…This positive trend is due to more appropriate embryo transfer strategies, milder ovarian stimulation, laboratory technological advances, and improved culture media [5]. However, even in singleton pregnancy, after adjustment for maternal confounding factors, the risk of multiple adverse outcomes during the perinatal period, including miscarriage, preterm birth, small for gestational age, low birth weight and gestational hypertension, are higher in IVF-ET pregnancies than in spontaneously conceived pregnancies [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The placental transcriptome of the first-trimester placenta is affected by in vitro fertilization and embryo transfer

Zhao¹,

Zheng²,

Liu³

et al. 2019

Reprod Biol Endocrinol

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Background: The placenta is a highly specialized temporary organ that is related to fetal development and pregnancy outcomes, and epidemiological data demonstrate an increased risk of placental abnormality after in vitro fertilization and embryo transfer (IVF-ET). Methods: This study examines alterations in the transcriptome profile of first-trimester placentas from IVF-ET pregnancies and analyzes the potential mechanisms that play a role in the adverse perinatal outcomes associated with IVF-ET procedures. Four human placental villi from first-trimester samples were obtained through fetal bud aspiration from patients subjected to IVF-ET due to oviductal factors. An additional four control human placental villi were derived from a group of subjects who spontaneously conceived a twin pregnancy. We analyzed their transcriptomes by microarray. Then, RT-qPCR and immunohistochemistry were utilized to analyze several dysregulated genes to validate the microarray results. Biological functions and pathways were analyzed with bioinformatics tools. Results: A total of 3405 differentially regulated genes were identified as significantly dysregulated (> 2-fold change; P < 0.05) in the IVF-ET placenta in the first trimester: 1910 upregulated and 1495 downregulated genes. Functional enrichment analysis of the differentially regulated genes demonstrated that the genes were involved in more than 50 biological processes and pathways that have been shown to play important roles in the first trimester in vivo. These pathways can be clustered into coagulation cascades, immune response, transmembrane signaling, metabolism, cell cycle, stress control, invasion and vascularization. Nearly the same number of up-and downregulated genes participate in the same biological processes related to placental development and maintenance. Procedures utilized in IVF-ET altered the expression of first-trimester placental genes that are critical to these biological processes and triggered a compensatory mechanism during early implantation in vivo. Conclusion: These data provide a potential basis for further analysis of the higher frequency of adverse perinatal outcomes following IVF-ET, with the ultimate goal of developing safer IVF-ET protocols.

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Risk of adverse perinatal outcomes after oocyte donation: a systematic review and meta-analysis

Moreno-Sepúlveda

Checa

2019

J Assist Reprod Genet

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Comparison of perinatal outcomes following frozen embryo transfer cycles using autologous versus donor oocytes in women 40 to 43 years old: analysis of SART CORS data

Cited by 9 publications

References 16 publications

Endometrium preparation and perinatal outcomes in women undergoing single-blastocyst transfer in frozen cycles

Endometrium preparation and perinatal outcomes in women undergoing single-blastocyst transfer in frozen cycles

The placental transcriptome of the first-trimester placenta is affected by in vitro fertilization and embryo transfer

Risk of adverse perinatal outcomes after oocyte donation: a systematic review and meta-analysis

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