Comparison of permeability of poly(allylamine hydrochloride)/and poly(diallyldimethylammonium chloride)/poly(4-styrenesulfonate) multilayer films: Linear vs. exponential growth

Elżbieciak-Wodka, Magdalena; Kolasińska-Sojka, Marta; Nowak, Paweł; Warszyński, Piotr

doi:10.1016/j.jelechem.2014.11.035

Cited by 18 publications

(23 citation statements)

References 54 publications

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“…14,17,18 In this regime, which is common for polypeptides and polysaccharides, the film is less structured and more hydrated, and its thickness can reach micrometers after deposition of only a few tens of layers. 19 However, for the linear growth regime, a more stratified structure has been observed in which the layers are finely accommodated. 14 For films obtained using poly(diallyldimethylammonium chloride), PDADMAC and poly(styrenesulfonate) (PSS) polymers, both growth regimes have been observed according to the salt concentration and presence of a buffer.…”

Section: Introductionmentioning

confidence: 99%

Effect of pH on the Complex Coacervation and on the Formation of Layers of Sodium Alginate and PDADMAC

et al. 2020

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In this study, we investigated the thermodynamic features of a system based on oppositely charged polyelectrolytes, sodium alginate, and poly(diallyldimethylammonium chloride) (PDADMAC) at different pH values. Additionally, a comparison of the effects of the thermodynamic parameters on the growth of the layers based on the same polymers is presented. For this investigation, different techniques were combined to compare results from the association in solution and coassembled layers at the silicon surface. Dynamic light scattering (DLS) and isothermal titration calorimetry (ITC) were used for studies in solution, and the layer-by-layer technique was employed for the preparation of the polymer layers. Ellipsometry and atomic force microscopy (AFM) were used to characterize the layer thickness growth as a function of the solution pH, and interferometric confocal microscopy was employed to analyze the topography and roughness of the films. The titration of both polyelectrolytes in two different sequences of additions confirmed the mechanism; it involved a two-step process that was monitored by varying the enthalpy, as determined by ITC experiments, and the structural evolution of the aggregates into coacervates, according to DLS. The primary process is aggregation to form polyelectrolyte complexes having a smaller hydrodynamic diameter, which abruptly transit toward a secondary process because of the formation of coacervate particles that have a larger hydrodynamic diameter. Independent of pH and the sequence of addition, for the first process, both directions are entropically driven. However, the binding enthalpy (ΔH b ) decreased with a decrease in the pH of the solution. The layers grown for the PDADMAC/sodium alginate system demonstrated pH sensitivity with either linear or exponential behavior, depending on the pH values of the polyelectrolyte solutions. The more endothermic process at pH 10 afforded layers with a smaller thickness and with linear growth according to the increase in the number of layers from 5 to 20. Decreases in the pH of the solution resulted in the layers growing exponentially; additionally, a decrease in the ΔH b of the association in the solution was observed. The layer thicknesses measured using ellipsometry and AFM data were in good agreement. Additionally, the influence of pH on the roughness and topography of the films was observed. Films from basic dipping solutions resulted in surfaces that were more homogeneous with less roughness; in contrast, films with more layers and those formed in a low-pH dipping solution were rougher and less homogeneous.

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Section: Introductionmentioning

confidence: 99%

Effect of pH on the Complex Coacervation and on the Formation of Layers of Sodium Alginate and PDADMAC

et al. 2020

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“…More gradual increase of the "dry" film thickness than the "wet" film mass with the number of deposited bilayers can be associated with swelling of the film due its hydration. That swelling was extensively discussed in our previous publications concerning the hydration of films exhibiting linear and exponential growth [91,92]. If we assume that the same mass of silver nanoparticles is adsorbed as in QCM experiments and they form random closely packed structure with maximum packing fraction 0.64, the calculated (PEI/AgNPs) 6 film thickness (neglecting polymer and hydration water contribution) amounts to 23 nm, which is in a fair agreement with the value determined by ellipsometry and suggests film compaction and aggregation of AgNPs due to strong dispersive interactions between metallic nanoparticles, stronger than between polyelectrolyte chains.…”

Section: Characterization Of Multilayers Coatings Pei/agnpsmentioning

confidence: 92%

Nanostructured multilayer polyelectrolyte films with silver nanoparticles as antibacterial coatings

Kruk

Szczepanowicz

Kręgiel

et al. 2016

Colloids and Surfaces B: Biointerfaces

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“…Polyelectrolytes at lower ionization states adopt more globular rather than extended conformations due to lesser interchain repulsions, and since the lateral electrostatic repulsions between the polyelectrolytes of the same charge are weaker the resulting shells are generally thicker. For such films, the thickness increases with the number of deposited layers in an exponential manner as a result of interpenetration of polyelectrolytes in the interior of the multilayer . Given that thicker layers are less permeable, the half‐time of release of artemisinin encapsulated within chitosan/alginate multilayers was prolonged by tenfold when the shell was deposited at 0.5 m NaCl instead of in the absence of salts .…”

Section: Lbl To Control Drug Releasementioning

confidence: 99%

“…Given that thicker layers are less permeable, the half‐time of release of artemisinin encapsulated within chitosan/alginate multilayers was prolonged by tenfold when the shell was deposited at 0.5 m NaCl instead of in the absence of salts . However, it was also demonstrated that shells composed purely of strong polyelectrolytes are more permeable when deposited at higher ionic strengths, due to their “spongy” structure containing more water‐filled pores that facilitates the diffusion . For instance, faster drug release from dexamethasone nanoparticles was achieved when PDDA/PSS deposition was carried out at higher ionic strength compared to pure water .…”

Section: Lbl To Control Drug Releasementioning

confidence: 99%

Layer‐by‐Layer Coating of Solid Drug Cores: A Versatile Method to Improve Stability, Control Release and Tune Surface Properties

Połomska

Leroux

2016

Macromolecular Bioscience

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Layer-by-layer coating is a simple and versatile technique based on the sequential deposition of molecular species on planar surfaces or colloidal templates. Its relevance in drug delivery primarily emerges from its versatility to control the release rate of the cargo encapsulated within the colloidal core. The focus of this review is the layer-by-layer encapsulation of colloidal particles purely composed of drug, including the core fabrication step, coating materials and techniques, multilayer shell permeability control, and reported in vitro and in vivo outcomes.

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Comparison of permeability of poly(allylamine hydrochloride)/and poly(diallyldimethylammonium chloride)/poly(4-styrenesulfonate) multilayer films: Linear vs. exponential growth

Cited by 18 publications

References 54 publications

Effect of pH on the Complex Coacervation and on the Formation of Layers of Sodium Alginate and PDADMAC

Effect of pH on the Complex Coacervation and on the Formation of Layers of Sodium Alginate and PDADMAC

Nanostructured multilayer polyelectrolyte films with silver nanoparticles as antibacterial coatings

Layer‐by‐Layer Coating of Solid Drug Cores: A Versatile Method to Improve Stability, Control Release and Tune Surface Properties

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