Comparison of phospholipid composition and microstructure of milk fat globules contained in human milk and infant formulae

Liu, Yan; Liu, Qian; Zhao, Jianxin; Qiao, Weicang; Liu, Bin; Yang, Baoyu; Chen, Lijun

doi:10.1016/j.foodchem.2023.135762

Cited by 30 publications

(15 citation statements)

References 29 publications

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“…Milk fat globules (MFG) have recently attracted greater attention with the growing interest in nutritional, physiological and health properties [42]. Milk fat globule membranes (MFGM) are spatially heterogeneous, thus measurements of MFGM organization and dynamics require specific tool for the study of the 3D orientation [43].…”

Section: Resultsmentioning

confidence: 99%

Three-dimensional dipole orientation mapping with high temporal-spatial resolution using polarization modulation

Zhong,

Qiao,

et al. 2023

Preprint

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Fluorescence polarization microscopy is widely used in biology for molecular orientation properties. However, due to the limited temporal resolution of single-molecule orientation localization microscopy and the limited orientation dimension of polarization modulation techniques, achieving simultaneous high temporal-spatial resolution mapping of the three-dimensional (3D) orientation of fluorescent dipoles remains an outstanding problem. Here, we present a super-resolution 3D orientation mapping (3DOM) microscope that resolves 3D orientation by extracting phase information of the six polarization modulation components in reciprocal space. 3DOM achieves an azimuthal precision of 2° and a polar precision of 3° with spatial resolution of 128 nm in the experiments. We validate that 3DOM not only reveals the heterogeneity of the milk fat globule membrane, but also elucidates the 3D structure of biological filaments, including the 3D spatial conformation of λ-DNA and the structural disorder of actin filaments. Furthermore, 3DOM images the dipole dynamics of microtubules labeled with green fluorescent protein in live U2OS cells, reporting dynamic 3D orientation variations. Given its easy integration into existing wide-field microscopes, we expect the 3DOM microscope to provide a multi-view versatile strategy for investigating molecular structure and dynamics in biological macromolecules across multiple spatial and temporal scales.

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Section: Resultsmentioning

confidence: 99%

Three-dimensional dipole orientation mapping with high temporal-spatial resolution using polarization modulation

Zhong,

Qiao,

et al. 2023

Preprint

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“…Numerous studies have demonstrated that factors such as source, feeding regime, lactation period and season influence the contents of different traits in camel milk. Among them, season has the greatest relative impact on milk composition, with a variation ratio of 50% (Nagy et al 2019;Liu et al 2023). The samples in study were collected in February, when the temperature in the northern Xinjiang region is close to À15°C.…”

Section: Discussionmentioning

confidence: 99%

Quality characteristics and nutrient contents of Bactrian camel milk as determined by mid‐infrared spectroscopy

Li,

Liu,

Fan

et al. 2024

Int J of Dairy Tech

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Reference methods for determining the contents of functional traits in camel milk are expensive and complex, hindering their widespread use. Mid‐infrared technology has the advantages of fast, economic, batch processing for dairy detection. In the present study, mid‐infrared spectroscopy (MIRS) prediction models previously established based on cow milk were used to predict 1101 Bactrian camel milk samples in terms of fat, protein, lactose, total solids, total casein, β‐casein, K, Ca, Na and Mg contents. The MIRS‐predicted values for the 10 traits were close to the reference values, demonstrating the utility and efficiency of the proposed method. Furthermore, the quality characteristics of camel milk were compared with those of other dairy animals, confirming that it is a valuable and rich source of essential nutrients for humans.

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“…Therefore, there has been increasing focus on the role of MFGM and their use in simulated human milk fat globule (MFG) emulsions in recent years. However, most of the MFGM materials used in these studies were MFGM-rich whey protein powders, which has a significantly lower content of phospholipids (PLs) (6 %–10 %) compared to PLs found in HM MFGM (60 %–65 %) [3] , [4] , [5] . Phospholipid (PL) has the functions of promoting fat metabolism, enhancing immunity, and improving brain and nervous system development [6] .…”

Section: Introductionmentioning

confidence: 99%

Ultrasound modification on milk fat globule membrane and soy lecithin to improve the physicochemical properties, microstructure and stability of mimicking human milk fat emulsions

Ma,

Zhou,

Wang

et al. 2024

Ultrasonics Sonochemistry

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Comparison of phospholipid composition and microstructure of milk fat globules contained in human milk and infant formulae

Cited by 30 publications

References 29 publications

Three-dimensional dipole orientation mapping with high temporal-spatial resolution using polarization modulation

Three-dimensional dipole orientation mapping with high temporal-spatial resolution using polarization modulation

Quality characteristics and nutrient contents of Bactrian camel milk as determined by mid‐infrared spectroscopy

Ultrasound modification on milk fat globule membrane and soy lecithin to improve the physicochemical properties, microstructure and stability of mimicking human milk fat emulsions

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