Comparison of planar DMSA scan with an evaluation based on SPECT imaging in the split renal function assessment

Chroustová, Daniela; Trnka, Jiří; Šírová, Veřa; Urbanová, Ivana; Langer, J; Kubinyi, Jozef

doi:10.5603/nmr.2016.0003

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…Fifty-eight articles received full-article screening. Of these, we excluded the following: 22 studies were not relevant; 10 studies only included patients with kidney disease (and not kidney donors); 24-33 4 studies did not report Pearson’s r and data could not be extracted; 34-37 and 1 study compared SRF with SRV in mL/min rather than as a percent and was inappropriate for pooling. 38 The 21 eligible studies are described in Table 1 and were mathematically combined in meta-analysis along with the results from the London, Ontario chart review.…”

Section: Resultsmentioning

confidence: 99%

Can Split Renal Volume Assessment by Computed Tomography Replace Nuclear Split Renal Function in Living Kidney Donor Evaluations? A Systematic Review and Meta-Analysis

Habbous

Garcia-Ochoa

Brahm

et al. 2019

Can J Kidney Health Dis

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Background: As part of their living kidney donor assessment, all living donor candidates complete a computed tomography (CT) angiogram, but some also receive a nuclear renogram for split renal function (SRF%). Objective: We considered whether split renal volume (SRV%) assessed by CT can predict SRF%. Design: Systematic review and meta-analysis. Setting: Living donor candidates undergoing evaluation as potential living kidney donors. Patients: Living donor candidates who received both a nuclear renogram for split function and CT for SRV as part of their living donor work-up. Measurements: Split renal volume from CT scans and SRF from nuclear renography. Methods: We performed a systematic review and meta-analysis of the literature, abstracting data and digitizing plots where possible. We searched Medline, EMBASE, and the Cochrane Library. We added data from donor candidates assessed in London, Ontario from 2013 to 2016. We used fixed and random-effects models to pool Fisher’s z-transformed Pearson’s correlation coefficient ( r). We conducted random-effects meta-regression on digitized and aggregate data. Studies were restricted to living kidney donors or living donor candidates. Results: After pooling 19 studies (n = 1479), we obtained a pooled correlation of r = 0.74 (95% confidence interval [CI] = 0.61-0.82). By linear regression using individual-level data, we observed a 0.76% (95% CI = 0.71-0.81) increase in SRF% for every 1% increase in SRV%. Split renal volume had a specificity of 88% for discriminating SRF at a threshold that could influence the decision of which kidney is to be removed (between-kidney difference ≥10%). Predonation SRV and SRF both moderately predicted kidney function 6 to 12 months after donation: r = 0.75 for SRV and r = 0.73 for SRF; Δ r = 0.05 (–0.02, 0.13). Limitations: Most studies were retrospective and measured SRV and SRF only on selected living donor candidates. Efficiency gains in removing the SRF from the evaluation will depend on the transplant program. Conclusion: Split renal volume has the potential to replace SRF for some candidates. However, it is uncertain whether it can do so reliably and routinely across different transplant centers. The impact on clinical decision-making needs to be assessed in well-designed prospective studies. Trial registration: The digitized data are registered with Mendeley Data (doi10.17632/dyn2bfgxxj.2).

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Section: Resultsmentioning

confidence: 99%

Can Split Renal Volume Assessment by Computed Tomography Replace Nuclear Split Renal Function in Living Kidney Donor Evaluations? A Systematic Review and Meta-Analysis

Habbous

Garcia-Ochoa

Brahm

et al. 2019

Can J Kidney Health Dis

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“…Such difference in depth could yield corrupted relative renal function quantification [19]. In clinical routines, the mean geometric method has been used in order to correct the kidney depth based on the anterior and the posterior projection [20]. e ameliorated renal count after the attenuation correction could be computed by…”

Section: Attenuation Correctionmentioning

confidence: 99%

Relative Ectopic Kidney Function Quantification Using DMSA Tomoscintigraphy Modality

Njeh¹,

Chtourou

BenHamida³

2020

Journal of Healthcare Engineering

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The ectopic renal function estimation based on a manual region of interest (ROI) extraction could be considered as time consuming. It could also affect the clinical interpretation and thus deviate the therapeutic attitude. For this purpose, we propose an advanced tool to evaluate such function through the dimercaptosuccinic acid (DMSA) kidney scintigraphy scans. Methods. The proposed study has been performed on one hundred patients (fifty cases with normal kidneys and fifty cases with ectopic kidneys). We present our segmentation problems as several cost functions’ optimization, each containing two terms: (i) a distribution matching prior, which evaluates a global similarity between distributions, and (ii) a smoothness prior to avoid the occurrence of small, isolated regions in the solution. Obtained following recent bound-relaxation results, the optima of the cost functions yield each kidney region in near real time. The Dice Metric (DM), the Jaccard Index (JI), and the correlation parameter have been adopted as validation parameters in order to evaluate the segmentation results. The obtained relative function of both kidneys has been then compared with that evaluated in clinical routine (planar projection) and then validated statistically by the Bland–Altman plots and the Interclass Correlation Coefficient (ICC). Results. Compared to the expert’s manual kidney segmentation, the obtained results have been judged to be acceptable for clinical use with high Mean Dice Metric (MDM) value and high Jaccard Index (JI). The evaluated relative renal function has been different from those calculated by the projection planar method usually used in clinical routines. Conclusion. The proposed system could efficiently extract the renal region. The relative function estimation could be considered as more accurate. In fact, the background noise correction and the attenuation phenomenon, which could yield an error measure for renal ectopia, have been avoided. Our clinical staff members have validated the results and have suggested using such tool in their clinical routines.

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“…In the evaluation of SRF, scintigraphic methods are used such as technetium‐99m‐mercaptoacetyltriglycine ( 99m Tc‐MAG3), 99m Tc‐DTPA, technetium‐99m‐dimercaptosuccinic acid ( 99m Tc)‐DMSA and chromium‐51 ethylenediamine tetraacetic acid ( 51 Cr‐EDTA) and so forth. (Cao et al, 2016; Chroustová et al, 2016; Gardan et al, 2018; Miyazaki et al, 2010; Ritchie et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Comparison of tomographic kidney volumes measured by semiautomatic segmentation method with scintigraphic split renal function in predicting posttransplant kidney functions

Yılmaz

Tulum

Dandin

et al. 2022

Clin Physio Funct Imaging

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Introduction:In this study, it was aimed to compare scintigraphic split renal function (SRF) and computed tomographic (CT) kidney volumes by semiautomatic segmentation method in predicting graft functions after kidney transplantation.Methods: One hundred and twelve patients (77 males, 35 females) who had a living-donor kidney transplant between 2015 and 2017 in our centre were included in the study. While SRF was calculated with technetium-99mdiethylenetriaminepentaacetic acid ( 99m Tc-DTPA) scintigraphy, CT angiography was used for volumetric calculations.Results: CT-volumetric measurements, especially renal cortical volume (RCV:103.8 ± 20 ml) and ratio to body mass index (RCV/BMI: 4.45 ± 1.3) were found to be more significant than 99m Tc-DTPA-SRF in predicting graft functions. The correlations between SRF and RCV with 6th-month estimated glomerular filtration rate (eGFR) (rSRF: 0.052, rRCV: 0.317, p = 0.041) and 1st-year eGFR (rSRF: 0.104, rRCV: 0.374, p = 0.033) were found to be more significant in favour of RCV. The correlation between SRF/BMI and RCV/BMI with 1st-, 6th-and 12th-month eGFR (respectively, p = 0.02/0.048/0.024) were found to be more significant in favour of RCV/BMI. Although univariate analysis showed a significant relationship between most volumetric measurements and 1st-year graft functions, in multivariate analysis only RCV [odds ratio (OR): 1.04 (1.01-1.07), p = 0.023] and RCV/BMI [OR: 2.5 (1.27-5.39), p = 0.013] showed a significant relationship between graft functions. Conclusion:In our study, it was shown that CT-based renal volumetric measurements, especially RCV and RCV/BMI, predicted graft functions more strongly than scintigraphic 99m Tc-DTPA-SRF.

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Comparison of planar DMSA scan with an evaluation based on SPECT imaging in the split renal function assessment

Abstract: BACKGROUND: Validation of the

Cited by 6 publications

References 16 publications

Can Split Renal Volume Assessment by Computed Tomography Replace Nuclear Split Renal Function in Living Kidney Donor Evaluations? A Systematic Review and Meta-Analysis

Can Split Renal Volume Assessment by Computed Tomography Replace Nuclear Split Renal Function in Living Kidney Donor Evaluations? A Systematic Review and Meta-Analysis

Relative Ectopic Kidney Function Quantification Using DMSA Tomoscintigraphy Modality

Comparison of tomographic kidney volumes measured by semiautomatic segmentation method with scintigraphic split renal function in predicting posttransplant kidney functions

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